Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women.
Nutr J. 2012 Dec 27;11(1):114.
Roth DE, Mahmud A, Raqib R, Black RE, Baqui AH.
BACKGROUND: Improvements in antenatal vitamin D status may have maternal-infant health benefits. To inform the design of prenatal vitamin D3 trials, we conducted a pharmacokinetic study of single-dose vitamin D3 supplementation in women of reproductive age.
METHODS:
A single oral vitamin D3 dose (70,000 IU) was administered to 34 non-pregnant and 27 pregnant women (27 to 30 weeks gestation) enrolled in Dhaka, Bangladesh (23[degree sign]N). The primary pharmacokinetic outcome measure was the change in serum 25-hydroxyvitamin D concentration over time, estimated using model-independent pharmacokinetic parameters.
RESULTS:
Baseline mean serum 25-hydroxyvitamin D concentration was 54 nmol/L (95% CI 47, 62) in non-pregnant participants and 39 nmol/L (95% CI 34, 45) in pregnant women. Mean peak rise in serum 25-hydroxyvitamin D concentration above baseline was similar in non-pregnant and pregnant women (28 nmol/L and 32 nmol/L, respectively). However, the rate of rise was slightly slower in pregnant women (i.e., lower 25-hydroxyvitamin D on day 2 and higher 25-hydroxyvitamin D on day 21 versus non-pregnant participants). Overall, average 25-hydroxyvitamin D concentration was 19 nmol/L above baseline during the first month. Supplementation did not induce hypercalcemia, and there were no supplement-related adverse events.
CONCLUSIONS:
The response to a single 70,000 IU dose of vitamin D3 was similar in pregnant and non-pregnant women in Dhaka and consistent with previous studies in non-pregnant adults. These preliminary data support the further investigation of antenatal vitamin D3 regimens involving doses of <=70,000 IU in regions where maternal-infant vitamin D deficiency is common.Trial registration: ClinicalTrials.gov (NCT00938600). PMID: 23268736
Response (from preliminary PDF)
Preliminary PDF is attached at the bottom of this page
Response to 100,000 IU in another study
Should have 50,000 IU every week during pregnancy
Everyone should have 50,000 IU every two weeks at a minimum
See also VitaminDWiki
- Overview Loading of vitamin D
- Variety of vitamin D loading dose recommendations in the UK - 2011
- All Megadose vitamin D items
207 items - Half-life of vitamin D varies
- Overview Pregnancy and vitamin D
- Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019
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