Asthma and Vitamin D Receptor - many pages

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10+ Vitamin D Receptor pages have ASTHMA in the title

The list is automatically updated

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Asthmatics with a poor Vitamin D Receptor were 4 X more likely to have exacerbation in 1 year - Jan 2025

Vitamin D Receptor rs2228570 Gene Polymorphism Is Associated with Asthma Severity and Exacerbations
Sekiko Uehara, Keita Hirai , Toshihiro Shirai, Hinako Otaki, Taisuke Akamatsu, Kunihiko Itoh
Biological and Pharmaceutical Bulletin 2025 Volume 48 Issue 1 Pages 86-92 DOI https://doi.org/10.1248/bpb.b24-00684

Vitamin D plays a crucial role in immune system function. Several studies have indicated that genetic variations in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP, encoded by GC gene) increase the risk of developing asthma. However, the effect of these variations on the prognosis and clinical outcomes of asthma remains unclear. This study, involving 152 adult patients with asthma, aimed to assess the influence of VDR and GC polymorphisms on asthma severity and its exacerbation. Gene polymorphisms previously associated with asthma risk were analyzed, and VDR mRNA expression levels were evaluated in peripheral blood mononuclear cells.
The AA genotype of the VDR rs2228570 polymorphism was associated with an

• elevated risk of severe asthma compared to the AG/GG genotype ( odds ratio, 3.20; 95% confidence interval [CI], 1.24–8.28).

Furthermore, patients with the rs2228570 AA genotype showed an

• elevated risk of exacerbation during the 1-year follow-up period (hazard ratio, 4.01; 95% CI, 1.75–9.15).

VDR mRNA expression was significantly reduced in patients with the AA genotype. Furthermore, the mRNA expression levels of GLCCI1, HDAC2, NR3C1, and NFE2L2, which are associated with steroid response, were reduced in patients with the AA genotype.
Our findings indicate that patients with the AA genotype of VDR rs2228570 are more likely to experience severe asthma and exacerbations. This polymorphism has the potential to reduce vitamin D efficacy by altering VDR function and expression, potentially resulting in increased inflammation and reduced steroid responsiveness in patients with asthma.
 Download the PDF from VitaminDWiki

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Best VDR Activators for prevent/treat Asthma: Resveratrol, Quercetin, Curcumin - Feb 2025

Asked Perplexity AI - Deep Research
The many supplements that activate the Vitamin D Receptor include Magnesium, Omega-3, Resveratrol, Quercetin , Zinc, Boron, ginger, curcumin, Progesterone, Sulfroaphane, Butyrate, and Berberine. Is there any hint as to which one is best for Asthma?

The Role of Vitamin D Receptor-Activating Supplements in Asthma Management: A Comprehensive Analysis
Summary of Key Findings
Emerging research highlights the potential of various dietary supplements to modulate asthma pathophysiology through activation of the Vitamin D Receptor (VDR). Among the supplements investigated—Magnesium, Omega-3, Resveratrol, Quercetin, Zinc, Boron, Ginger, Curcumin, Progesterone, Sulforaphane, Butyrate, and Berberine
—three compounds stand out for their robust evidence in asthma models: Resveratrol, Quercetin, and Curcumin.
These agents demonstrate synergistic effects with Vitamin D, reduce airway inflammation, and improve clinical outcomes in preclinical and clinical studies.
Mechanisms of VDR Activation and Asthma Pathophysiology
The VDR plays a pivotal role in immune regulation and airway homeostasis. Polymorphisms in the VDR gene are associated with increased asthma susceptibility, highlighting its importance in disease modulation 5 14. Vitamin D itself enhances steroid responsiveness by upregulating glucocorticoid receptors (GR-α) and suppressing pro-inflammatory cytokines like IL-17F and IL-4 7 22. Supplements that potentiate VDR signaling may amplify these benefits, particularly in patients with Vitamin D deficiency or steroid resistance.
Comparative Analysis of Key Supplements
 1) Resveratrol
Resveratrol, a polyphenol found in grapes and berries, demonstrates multifaceted anti-asthmatic effects:

• Anti-Inflammatory Action: Reduces eosinophil infiltration, Th2 cytokines (IL-4, IL-5, IL-13), and TGF-β1-driven epithelial-mesenchymal transition (EMT), a key process in airway remodeling 9 10.
• Synergy with Vitamin D: Enhances VDR-RXR heterodimerization and potentiates 1,25D binding to VDR, amplifying anti-inflammatory effects 11.
• Clinical Relevance: Suppresses airway hyperresponsiveness (AHR) and inflammation in murine models, with efficacy comparable to corticosteroids but with fewer side effects 10 12.

2) Quercetin
Quercetin, a flavonoid abundant in fruits and vegetables, exhibits rapid bronchodilatory and immunomodulatory effects:

• Bronchodilation: Inhibits phosphodiesterase-4 (PDE4), increasing cAMP levels and relaxing airway smooth muscle 17 18.
• Immune Regulation: Shifts Th1/Th2 balance by suppressing GATA-3 (Th2 transcription factor) and enhancing T-bet (Th1 promoter), reducing IgE and eosinophil levels 18 20.
• Oxidative Stress Mitigation: Activates Nrf2/HO-1 pathways, reducing lipid peroxidation and enhancing antioxidant defenses 19.

3) Curcumin
Curcumin, the active compound in turmeric, modulates critical inflammatory pathways:

• PPARγ Activation: Suppresses NF-κB-driven inflammation and mucus hypersecretion in ovalbumin (OVA)-induced asthma models 4.
• Airway Remodeling: Attenuates subepithelial fibrosis and collagen deposition by inhibiting TGF-β/Smad signaling 19.
• Clinical Trials: Reduces exacerbations and improves lung function in combination with standard therapies, though direct VDR interactions require further study 4.

Supporting Evidence for Other Supplements

• Magnesium: While serum magnesium levels correlate with asthma severity, its role is primarily as a bronchodilator rather than a direct VDR activator 3.
• Berberine: Limited evidence in asthma; focuses on metabolic and antimicrobial benefits 21.
• Zinc, Omega-3, Sulforaphane: Absent from the provided studies in an asthma context, though theoretical immune benefits exist.

Conclusion: Prioritizing Supplements for Asthma Management
Based on current evidence:

1. Resveratrol emerges as the most promising due to its dual anti-inflammatory and VDR-synergistic effects, particularly in steroid-resistant asthma.
2. Quercetin offers acute symptom relief and long-term immune modulation, making it ideal for exacerbation management.
3. Curcumin provides robust anti-remodeling effects, though further research is needed to clarify its VDR-specific mechanisms.

Clinical Implications: Combining these supplements with Vitamin D supplementation may optimize outcomes, especially in deficient populations. Future trials should explore dose-response relationships and synergistic formulations.
Future Directions

• Personalized Medicine: Genetic screening for VDR polymorphisms could identify patients most likely to benefit from supplementation 5 14.
• Combination Therapies: Investigating Resveratrol + Vitamin D or Quercetin + corticosteroids may enhance efficacy while minimizing steroid doses.
• Long-Term Safety: Despite promising data, prolonged use of high-dose supplements requires rigorous safety assessments.

This analysis underscores the potential of natural compounds to complement conventional asthma therapies, offering a paradigm shift toward integrative

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VitaminDWiki – Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • Probably need gut-friendly Vitamin D
• CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 99 health problems prevented/treated as of Feb 2025
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on the chart to see the study

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VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor

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TENS may treat Asthma via the Vegus nerve (along with many other health problems) - Feb 2025

Perplexity AI

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A poor VDR increases the risk of Asthma (but not the opposite assocation) - Feb 2025

What is the direction of the association between the Vitamin D receptor and Asthma? Does a poor VDR increase the risk of Asthma or does Asthma reduce the activation of the VDR?
Perplexity Deep Research

• Parkinson's Disease might be treated by TENS