Autoimmunity problems often associated with poor Vitamin D Receptors – March 2019

Immunological effects of vitamin D and their relations to autoimmunity

Journal of Autoimmunity https://doi.Org/10.1016/j.jaut.2019.03.002

VitaminDWiki

Autoimmune category starts with

200 items in Autoimmune category
Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Lupus Psoriasis
Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
- Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
- All 43 references are FREE on-line
Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
Autoimmune disease clusters run in families having low D
How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
Vitamin D Receptor is associated in over 58 autoimmune studies
More autoimmune disease if higher pollution or lower UVB - Feb 2023
Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019

See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:

Items in both categories Autoimmune and Vitamin D Receptor are listed here:

The risk of 41 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what compensates for low VDR activation
Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Vitamin D Receptor and Cancers
89+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updated

Items found: 90

Title		Modified
Breast Cancer prevented in 5 ways via the Vitamin D Receptor – Oct 2024		02 Nov, 2024
Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis Sept 2024		06 Sep, 2024
Pancreatic Cancer protects itself deactivating HNF4A (which can be reactivated by the Vitamin D Receptor) – April 2024		29 Jul, 2024
Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024		29 Jun, 2024
Vitamin D Receptor (Cancers OR Viruses) - many studies		02 Mar, 2024
Oral Cancer and Vitamin D and VDR - several studies		11 Feb, 2024
Breast Cancer risk reduced if consume butyrate - Dec 2023		23 Jan, 2024
An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023		13 Jan, 2024
Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023		27 May, 2023
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022		06 Dec, 2022
Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022		31 Oct, 2022
2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012		16 Sep, 2022
Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022		15 Aug, 2022
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022		27 Jul, 2022
Breast Cancer, Vitamin D, and genes – Welsh Nov 2021		09 Feb, 2022
How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020		01 Nov, 2021
Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021		25 Oct, 2021
Cancers and Vitamin D Receptors, including change with race – Feb 2021		24 Oct, 2021
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies		18 Oct, 2021
After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021		20 Aug, 2021
Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021		10 Jul, 2021
Oral Cancers - increased risk if low vitamin D or poor vitamin D genes		22 Jan, 2021
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021		15 Jan, 2021
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020		09 Dec, 2020
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020		02 May, 2020
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020		22 Jan, 2020
8 ways that Cancer might be prevented by Vitamin D - June 2019		26 Dec, 2019
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019		14 Dec, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019		15 Nov, 2019
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016		09 Nov, 2019
Cancer is leading cause of death - Vitamin D and Receptor activators help		09 Nov, 2019
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019		06 Nov, 2019
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019		19 Oct, 2019
Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019		23 Aug, 2019
Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019		29 Jul, 2019
Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies		14 Jun, 2019
Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019		14 Jun, 2019
Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019		13 Jun, 2019
After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019		04 Jun, 2019
Effects of Resveratrol against Lung Cancer in mice – Nov 2017		28 Apr, 2019
The Role of Resveratrol in Cancer Therapy – Dec 2017		27 Apr, 2019
Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019		11 Apr, 2019
A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019		26 Mar, 2019
Breast Cancer and Vitamin D review – March 2018		17 Mar, 2019
Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018		15 Mar, 2019
Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019		11 Feb, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018		09 Dec, 2018
Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018		10 Nov, 2018
Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018		01 Nov, 2018
Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010		03 Oct, 2018
Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018		15 Aug, 2018
Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018		08 Aug, 2018
Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018		07 Jul, 2018
Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018		16 Jun, 2018
Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018		28 Mar, 2018
Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018		17 Mar, 2018
Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017		14 Dec, 2017
Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017		19 Oct, 2017
Cancer and the Vitamin D Receptor, a primer – Sept 2017		01 Oct, 2017
Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017		26 Aug, 2017
Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017		19 Aug, 2017
Cancer risks and Vitamin D Receptors – association is unclear – 2017		19 Aug, 2017
Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016		09 Aug, 2017
Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017		02 Aug, 2017
Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017		27 Jul, 2017
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014		25 Jul, 2017
Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015		15 Jun, 2017
Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015		17 Mar, 2017
Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017		06 Mar, 2017
2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017		04 Mar, 2017
Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015		02 Mar, 2017
Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017		01 Mar, 2017
Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013		27 Feb, 2017
Vitamin D receptor may suppress skin cancer – Dec 2013		27 Jan, 2017
Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017		28 Dec, 2016
Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016		06 Dec, 2016
Vitamin D, Vitamin D Receptor and Cancer – Nov 2016		05 Dec, 2016
High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016		14 Nov, 2016
2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013		14 Nov, 2016
Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014		12 Nov, 2016
10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012		23 Sep, 2016
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013		17 Mar, 2016
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015		06 Jan, 2016
Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014		13 Dec, 2015
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015		18 Oct, 2015
Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015		03 May, 2015
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013		06 Jan, 2014
Genes breast cancer and vitamin D receptor - Sept 2010		08 Jul, 2013
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012		08 Jul, 2013
Vitamin D receptor in breasts and breast cancer vary with race – March 2013		08 Jul, 2013

Download the PDF from sci-hub via VitaminDWiki

Erin Yamamoto a, Trine N. J0rgensen b’ jorgent@ccf.org
a Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA
b Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA

Vitamin D deficiency is an established risk factor for many autoimmune diseases and the anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these diseases. However, results of vitamin D3 supplementation clinical trials have been varied. To understand the clinical heterogeneity, we reviewed the pre-clinical data on vitamin D activity in four common autoimmune diseases:

multiple sclerosis (MS),
rheumatoid arthritis (RA),
systemic lupus erythematosus (SLE), and
inflammatory bowel disease (IBD),

in which patients are commonly maintained on oral vitamin D3 supplementation. In contrast, many pre-clinical studies utilize other methods of manipulation (i.e. genetic, injection). Given the many actions of vitamin D3 and data supporting a vitamin D-independent role of the Vitamin D receptor (VDR), a more detailed mechanistic understanding of vitamin D3 activity is needed to properly translate pre-clinical findings into the clinic. Therefore, we assessed studies based on route of vitamin D3 administration, and identified where discrepancies in results exist and where more research is needed to establish the benefit of vitamin D supplementation.