Impact of Vitamin D in the Treatment of Tuberculosis
American Journal of the Medical Sciences: Review Article
June 2011 - Volume 341 - Issue 6 - pp 493-498
doi: 10.1097/MAJ.0b013e3182070f47
Luong, Khanh vinh quoc MD; Nguyen, Lan Thi Hoang MD
From the Vietnamese American Research Foundation, Westminster, California.
Submitted July 20, 2010; accepted in revised form November 12, 2010.
Correspondence: Khanh vinh quoc Luong, MD, 14971 Brookhurst Street, Westminster, CA 92683 (E-mail: Lng2687765@aol.com).
Tuberculosis (TB) is a major global health problem and often coincides with nutritional deficiency. In fact, vitamin D deficiency has been reported among TB patients, and vitamin D receptor polymorphisms are associated with susceptibility to Mycobacterium tuberculosis. High doses of vitamin D were widely used to treat TB patients in the preantibiotic era. This approach was successful: vitamin D can suppress intracellular growth of M tuberculosis in vitro. Vitamin D also induced the expression of cathelicidin, which is involved in the first line of defense in TB patients. Thus, vitamin D may have a role in TB treatment, and further investigation is needed.
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