An Investigation of Bone Health Subsequent to Vitamin D Supplementation in Children Following Burn Injury.
Nutr Clin Pract. 2015 May 29. doi: 10.1177/0884533615587720
Mayes T1, Gottschlich MM2, Khoury J3, Kagan RJ4.
1Department of Nutrition, Shriners Hospitals for Children, Cincinnati, Ohio Division of Nutrition Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio theresa.mayes@cchmc.org.
2Department of Nutrition, Shriners Hospitals for Children, Cincinnati, Ohio Department of Research, Shriners Hospitals for Children, Cincinnati, Ohio Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
3Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
4Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio Department of Surgery, Shriners Hospitals for Children, Cincinnati, Ohio.
6 fractures total
| 4 | placebo |
| 2 | Vitamin D2 |
| 0 | Vitamin D3 |
Unfortunately abstract does not indicate dose size
Publisher wants $30 for the PDF
See also VitaminDWiki
Burns, ulcers, and wounds healed by Vitamin D - many studies 100,000 IU
Hypothesis: Extensive burns reduce vitamin D, which increase bone loss – Nov 2012
Burned skin produces only about 25 percent as much vitamin D – March 2012
BACKGROUND:
The effect of supplemental vitamin D on fracture occurrence following burn injuries is unclear. The objective of this study was to evaluate postintervention incidence of fractures in children during the rehabilitative phase postburn (PB) following participation in a randomized clinical trial of vitamin D supplementation.
MATERIALS AND METHODS:
Follow-up for fracture evaluation was obtained in 39 of 50 patients randomized to daily enteral vitamin D2, D3, or placebo throughout the acute burn course. Serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, D2, D3, calcitonin, and bone alkaline phosphatase (BAP) measurements were obtained PB day 7, midpoint, discharge, and 1-year PB. Urinary calcium was obtained PB day 7 and midpoint. Dual-energy x-ray absorptiometry (DXA) was performed at discharge and 1-year PB.
RESULTS:
Fractures were reported in 6 of 39 respondents. Four fractures occurred in the placebo group, 2 in the D2 group, and none in the D3 group. Serum vitamin D, calcitonin, BAP, and urinary calcium were similar between fracture groups. The group with fracture morbidity had larger burn size (83.8% ± 4.9% vs 53.0% ± 2.9%, P < .0001), greater full-thickness burn (69.7% ± 9.4% vs 39.4% ± 4.1%, P = .02), and increased incidence of inhalation injury (33% vs 6%, P = .04). Decreased bone mineral density z score was noted at discharge in the placebo fracture compared with no-fracture group (P < .05).
CONCLUSION:
This preliminary report suggests there may be benefit of vitamin D3 in reducing postdischarge fracture risk. Results reaffirm the importance of monitoring bone health in pediatric patients postburn.
© 2015 American Society for Parenteral and Enteral Nutrition.
PMID: 26024678