Insight into the roles of vitamins C and D against cancer: Myth or truth?
Cancer Lett. 2018 May 29;431:161-170. doi: 10.1016/j.canlet.2018.05.039. [Epub ahead of print]
Zhao CN1, Li Y1, Meng X1, Li S2, Liu Q1, Tang GY1, Gan RY3, Li HB4.
- Hypothesis – anticancer benefits from synergy of omega-3 and vitamin D – May 2011
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Dr. Grant
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The consumption of vitamins C and D for prevention and treatment of cancer is still an uncertain recommendation due to their controversial roles in cancer. The epidemiological studies document that vitamins C and D possess potential antineoplastic property. In addition, accumulating experimental studies strongly support their anticancer efficacy both in vitro and in vivo, although the mechanisms of action are not completely clear. Vitamin C at pharmacological concentration has cancer-selective cytotoxicity in several cancer cell lines. Moreover, the cognition of vitamin D has become "hormone D", which modulates a variety of molecular targets and signaling pathways, contributing to the inhibition of cancer. Furthermore, limited small-scale clinical trials favor their roles as the adjuncts of standard cancer therapies. On the other hand, opposite opinions also exist, and high-quality evidence are still lacking to ascertain the roles of vitamins C and D in cancer. In general, in light of the potential and promising anticancer values of vitamins C and D, it is essential to gain insight into their roles in cancer based on current epidemiological, experimental and clinical studies.PMID: 29857128 DOI: 10.1016/j.canlet.2018.05.039
PDF is available free at Sci-Hub 10.1016/j.canlet.2018.05.039
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