C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019

Effect of vitamin D supplementation on the level of circulating high-sensitivity C-reactive protein: a meta-analysis of randomized controlled trials - 2014

Nutrients. 2014 Jun 10;6(6):2206-16. doi: 10.3390/nu6062206.
Chen N1, Wan Z2, Han SF3, Li BY4, Zhang ZL5, Qin LQ6.


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Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker. Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level. A systematic literature search was conducted in September 2013 (updated in February 2014) via PubMed, Web of Science, and Cochrane library to identify eligible studies. Either a fixed-effects or a random-effects model was used to calculate pooled effects. The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, -2.13, -0.03), with the evidence of heterogeneity. Subgroup analysis suggested a higher reduction of 2.21 mg/L (95% CI, -3.50, -0.92) among participants with baseline hs-CRP level ≥5 mg/L. Meta-regression analysis further revealed that baseline hs-CRP level, supplemental dose of vitamin D and intervention duration together may be attributed to the heterogeneity across studies. In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP. However, the result should be interpreted with caution because of the evidence of heterogeneity.
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Effect of Vitamin K Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis - 2019

Endocr Metab Immune Disord Drug Targets. 2019;19(1):13-25. doi: 10.2174/1871530318666180703125007.
Verma H1,2,3, Garg R1,2.

BACKGROUND:
Multiple cross sectional and longitudinal studies reported the benefits of vitamin K intake for management of cardiometabolic risk factors so as to minimize the risk of cardiovascular diseases.

OBJECTIVE: In present systematic review and meta-analysis, we aimed to evaluate the effect of vitamin K supplementation on cardiometabolic risk factors.

METHODOLOGY:
A systematic literature search of PubMed, Cochrane central, Clinicaltrials.gov, Google Scholar, Web of Science, EBSCO and Scopus databases was done from inception to November, 2017. A total of 13 trials were selected for inclusion into the present systematic review to evaluate the effect of vitamin K supplementation on cardiometabolic risk factors in healthy or in population at high risk of cardiovascular diseases.

RESULTS:
Significant beneficial effects of vitamin K supplementation were found only in case of Creactive protein (p = 0.01) and insulin sensitivity index (p <0.001), while no significant effects of vitamin K supplementation were found in case of total cholesterol (p=0.857), low density lipoprotein - cholesterol (p=0.964), high density lipoprotein - cholesterol (p=0.998), interleukin - 6 (p=0.766), systolic blood pressure (p=0.660), diastolic blood pressure (p=0.818), fasting plasma glucose (p=0.362), fasting plasma insulin (p=0.928) and homeostasis model assessment for insulin resistance (p=0.672).

CONCLUSION:
Presently available evidence are insufficient to ascertain the beneficial effects of vitamin K supplementation for the management of cardiometabolic risk factors. In order to explore the true potential of vitamin K supplementation for management of cardiometabolic diseases, large randomized placebo controlled trials are required in population with disturbed cardiometabolic profile. Present systematic review and meta-analysis is registered with PROSPERO (Registration number: CRD42018084608).

See also VitaminDWiki

16+ VitaminDWiki pages have REACTIVE or CRP in title

This list is automatcially updated

Items found: 20
Title Modified
Pancreatic Cancer protects itself deactivating HNF4A (which can be reactivated by the Vitamin D Receptor) – April 2024 29 Jul, 2024
Older adults 2.3 X more likely to die if low Vitamin D with high CRP - Feb 2024 05 Feb, 2024
Higher Vitamin D in seniors is associated with lower Inflammation (CRP) – June 2023 27 Aug, 2023
Rheumatoid Arthritis pain is reduced by Vitamin D, high doses also reduced inflammation (CRP) – Meta-analysis July 2023 13 Jul, 2023
Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022 27 Jun, 2022
Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020 20 Jun, 2022
Risk of Cardiovascular disease increased 2X if both low vitamin D and high C-reactive protein – April 2019 04 Jun, 2019
C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019 21 May, 2019
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017 01 Sep, 2017
Inflammatory blood markers (CRP, white blood cells) vary with Vitamin D level– Jan 2017 21 Jan, 2017
High maternal vitamin D resulted in 12 percent less inflammation (CRP) 20 years later – Oct 2016 21 Oct, 2016
Cardiovascular disease predicted by CRP and vitamin D, not cholesterol – Feb 2012 21 Oct, 2016
Inflammation (CRP) 3X higher in Winter-Spring neonates with low vitamin D – Nov 2015 10 Nov, 2015
Schizophrenia 4X less likely if both high vitamin D and high C-reactive protein – June 2015 19 Jul, 2015
Schizophrenia with high cRP is 4X less likely if high vitamin D – June 2015 17 Jul, 2015
4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010 28 Oct, 2014
Female mortality predicted better by vitamin D than by C-Reactive Protein – Dec 2013 20 Dec, 2013
Does C-Reactive Protein increase modestly with vitamin D – Jan 2012 20 Dec, 2013
Slow gait is 3.5X more likely with low vitamin D and high C-Reactive Protein – Aug 2013 16 Nov, 2013
HIV associated with low vitamin D and high C-reactive protein – Sept 2012 10 Aug, 2013

See also web

  • CRP, including what decreases it Self-Hacked Dec 2017
  • CRP Wikipedia
    "CRP rises within two hours of the onset of inflammation, up to 50,000-fold, and peaks at 48 hours. Its half-life of 18 hours is constant, and therefore its level is determined by the rate of production and hence the severity of the precipitating cause. CRP is thus a marker for inflammation that can be used to screen for inflammation."
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