Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial
The Lancet Respiratory Medicine, Available online 2 December 2014, doi:10.1016/S2213-2600(14)70255-3
Prof Adrian R Martineau, PhDa, b, , , Wai Yee James, RNa, Richard L Hooper, PhDa, Prof Neil C Barnes, FRCPa, b, David A Jolliffe, BSca, Claire L Greiller, MSca, Kamrul Islam, BSca, David McLaughlin, MRCGPa, Angshu Bhowmik, MDc, Peter M Timms, PhDc, Raj K Rajakulasingam, FRCPc, Marion Rowe, FIBMSc, Timothy R Venton, FIBMSc, Aklak B Choudhury, MRCPd, David E Simcock, PhDe, Mark Wilks, PhDe, Amarjeet Degun, MSce, Zia Sadique, PhDf, William R Monteiro, MResg, Prof Christopher J Corrigan, PhDh, Prof Catherine M Hawrylowicz, PhDh, Prof Christopher J Griffiths, DPhila, b, h
Purchase $31.50
2 months between dose of 3 mg
3000 ug = 120,000 IU
IF AVERAGE: 120,000 / 90 = 1300 IU
Also – many Vitamin D studies have found that 2 months is too long between doses
Only helped those with < 20 ng vitamin D level
See also VitaminDWiki
- COPD fought by Vitamin D - many studies
1700% better using high dose vitamin D, vs only 40% better with low dose on this page - 100000 IU vitamin D monthly helps COPD patients – 3 RCT
- Breathing category listing with many custom searches, such as the one which follows
- Search COPD 338 items as of Dec 2014
- Overview Loading of vitamin D current study is almost a loading dose study - so infrequent
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
Background
Patients with chronic obstructive pulmonary disease (COPD) often have vitamin D deficiency, which is associated with increased susceptibility to upper respiratory infection—a major precipitant of exacerbation. Multicentre trials of vitamin D supplementation for prevention of exacerbation and upper respiratory infection in patients with COPD are lacking. We therefore investigated whether vitamin D3 (colecalciferol) supplementation would reduce the incidence of moderate or severe COPD exacerbations and upper respiratory infections.
Methods
We did a randomised, double-blind, placebo-controlled trial of vitamin D3 supplementation in adults with COPD in 60 general practices and four Acute National Health Service Trust clinics in London, UK. Patients were allocated to receive six 2-monthly oral doses of 3 mg vitamin D3 or placebo over 1 year in a 1:1 ratio using computer-generated permuted block randomisation. Participants and study staff were masked to treatment assignment. Coprimary outcomes were time to first moderate or severe exacerbation and first upper respiratory infection. Analysis was by intention to treat. A prespecified subgroup analysis was done to assess whether effects of the intervention on the coprimary outcomes were modified by baseline vitamin D status. This trial is registered with ClinicalTrials.gov, number NCT00977873.
Findings
240 patients were randomly allocated to the vitamin D3 group (n=122) and placebo group (n=118). Vitamin D3 compared with placebo did not affect time to first moderate or severe exacerbation (adjusted hazard ratio 0·86, 95% CI 0·60–1·24, p=0·42) or time to first upper respiratory infection (0·95, 0·69–1·31, p=0·75). Prespecified subgroup analysis showed that vitamin D3 was protective against moderate or severe exacerbation in participants with baseline serum 25-hydroxyvitamin D concentrations of less than 50 nmol/L (0·57, 0·35–0·92, p=0·021), but not in those with baseline 25-hydroxyvitamin D levels of at least 50 nmol/L (1·45, 0·81–2·62, p=0·21; p=0·021 for interaction between allocation and baseline serum 25-hydroxyvitamin D status). Baseline vitamin D status did not modify the effect of the intervention on risk of upper respiratory infection (pinteraction=0·41).
Interpretation
Vitamin D3 supplementation protected against moderate or severe exacerbation, but not upper respiratory infection, in patients with COPD with baseline 25-hydroxyvitamin D levels of less than 50 nmol/L. Our findings suggest that correction of vitamin D deficiency in patients with COPD reduces the risk of moderate or severe exacerbation.