Serum 25-hydroxyvitamin D and risk of breast cancer

by Mohr, Sharif Burgette, Ph.D., UNIVERSITY OF CALIFORNIA, SAN DIEGO, 2012, 134 pages

Globally, a wide range of epidemiological studies have linked low levels of sunlight, ultraviolet B (UVB) irradiance, or serum 25-hydroxyvitamin D [25(OH)], with increased risk of breast cancer.

Three studies of different design were employed to assess the relationship between serum 25(OH)D and breast cancer risk.

1. The first study is an ecological analysis of the relationship between UVB irradiance and age-standardized breast cancer mortality rates worldwide.
   In the regression model, UVB irradiance was inversely associated with mortality rates (p = 0.04), after controlling for covariates.
   The overall model was statistically significant (R 2 = 0.34, p < 0.0001).
2. The second study was a case-control analysis of 600 incident cases of female breast cancer and their matched controls that investigated the inverse association between pre-diagnostic serum levels of 25(OH)D and risk of breast cancer in active-duty U.S. military personnel.
   Conditional logistic regression was used to assess the relationship between serum 25(OH)D concentration and breast cancer risk, while controlling for race and age.
   In this study, there was an inverse trend between serum 25(OH)D and odds of breast cancer that did not reach statistical significance.
   However, in 123 pairs for whom serum was collected 90 days or fewer before case diagnosis, women in the highest quintile of serum 25(OH)D had a 70% lower estimated risk of breast cancer (odds ratio 0.30, 95% confidence interval 0.12–0.74, p ? 0.01) compared to those in the lowest quintile.
3. The third study was a pooled analysis of published data from 11 ordinary and nested case-control studies.
   Data from all 11 studies were combined in order to calculate the pooled odds ratio of the highest vs lowest quintile of 25(OH)D.
   The pooled odds ratio summarizing the estimated risk in the highest compared to the lowest quintile across all studies was 0.63 (95% confidence interval 0.47, 0.80).

These three studies provide compelling evidence that supports a strong inverse relationship between vitamin D status and breast cancer risk.
More studies, including randomized controlled trials of higher doses of vitamin D3 (4,000 IU–6,000 IU/day), and serum levels of 25(OH)D (60–80 ng/ml), should be performed without delay.

Advisers Cedric F. Garland; Deborah L. Wingard
School UNIVERSITY OF CALIFORNIA, SAN DIEGO
Source DAI/B 73-10, p. , Jun 2012
Source Type Dissertation
Subjects Epidemiology; Oncology
Publication Number 3509936
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See also VitaminDWiki

• Not enough women willing to stop taking vitamin D to permit breast cancer clinical trial – June 2012
• All items in category Breast Cancer and Vitamin D 259 items
• Overview Breast Cancer and Vitamin D
• 6X less risk of death from Breast Cancer when vitamin D levels higher than 30 ng – May 2012
• Vitamin D and the mammary gland – review May 2012
• 85 % less risk of death from Breast Cancer when vitamin D levels higher than 30 ng – May 2012
• Worst breast cancer is 3X more frequent if less than 32 ng of vitamin D – March 2012
• Breast Cancer Chemotherapy initially decreases vitamin D levels – May 2012
• All items after Cancer Diagnosis 113 items
• Cancer Treatment and Prevention UK May 2011 Grassroots on Breast Cancer
• 2X more likely to survive breast cancer disease free if lots of vitamin D – July 2011
• UV decreased breast cancer risk by up to 2X – June 2011
• Cloudiness and Breast Cancer PDF file
• Need lots of UV AND vitamin D to reduce risk of breast cancer – Jan 2011
• Breast Cancer vs latitude Gapminder - Great U shaped curve
• No reduction in Breast Cancer if vitamin D was less than 40 ng - May 2011
• Breast Cancer recurred more when less than 20 ng of vitamin D – Oct 2010
• Breast cancer may result from poor interaction with vitamin D – Sept 2010 CYP27B1 and CYP24A1
• Recurrence of breast cancer not associated with vitamin D levels – Jan 2011
• Breast and other Cancer prevention - Dr. Wascher 2011 Blog and book
• Breast Cancer stages and vitamin D levels – 2011
• Breast Cancer vs vitamin D chart - 2010 chart follows

See also web

• Review of this item at Vitami D Councili
• Meta-analysis of vitamin D, calcium and the prevention of breast cancer 2010
  45% decrease in Breast Cancer for highest vs lowest vitamin D levels - without any vitamin D intervention!
• Not all types of Estrogen cause Breast Cancer July 2012
  Nice review, also mentions Vitamin D and Iodine deficiences