Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study
Annals of Medicine, Vol 50, 2018 - # 1, Pages 74-82, https://doi.org/10.1080/07853890.2017.1399446
Feitong Wu ORCID Icon, Markus Juonala, Niina Pitkänen, Antti Jula, Terho Lehtimäki, Matthew A. Sabin,
31 year study of 2,300 people in Finland
Keeping vitamin D above 25 ng from age 3-18 resulted in Type 2 Diabetes risk cut in half
- Can Vitamin D treat Diabetes - many articles
- Diabetes treated by vitamin D when levels exceeded 61 ng – Sept 2015
- Type 2 diabetes 1.5X more likely if low vs high vitamin D – meta-analysis Feb 2013
- Diabetic blacks – 80 percent had low vitamin D (less than 20 ng) a decade before – Sept 2017
Founder of VitaminDWiki supplements with Vitamin D + Magnesium + Omega-3
- Diabetes 29 % less likely if consume lots of Magnesium and cereal fiber (surveys of 200,000 people) – Oct 2017
- Type 2 Diabetes helped by Omega-3 and Vitamin D – Feb 2014
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
551 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 56 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 29 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetes category starts with the following
551 items In Diabetes category 34+ Prediabetes studies 64+ Type 1 Diabetes studies see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has204 items along with related searches Download the PDF from Sci-Hub via VitaminDWiki
Values are odds ratio (95% confidence interval) unless otherwise stated.
NFG: normal fasting glucose; IFG: impaired fasting glucose (cut-off 5.6mmol/L)
a Reference group for the outcome comparison.
bp < .1. Bold values denote statistical significance, p < .05.- Model 1: unadjusted;
- Model 2: adjusted for age, sex, body mass index, month of blood taken, parental history of diabetes and fruit consumption;
- Model 3: model 2 + physical activity, smoking, systolic blood pressure, high-density lipoprotein cholesterol, triglycerides, insulin, vegetable consumption, socioeconomic status (the parental length of time spent in education).
- Model 4: model 3 + adult body mass index (missing data of adult body mass index were imputed for 25 participants).
Objectives: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood.Materials and methods: This was a 31-year follow-up study of 2300 participants aged 3–18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life.
Results: High serum 25OHD levels in youth and also mean values from youth to adulthood were associated with reduced risk of developing T2DM in adulthood (odds ratio, 95% confidence interval= 0.73, 0.57–0.95 and 0.65, 0.51–0.84, respectively, for each SD increment in 25OHD). Compared to Q1, a dose-dependent negative association was observed across other quartiles of youth 25OHD, while the strongest association was found in the Q3 for the mean 25OHD levels. Neither youth nor the mean 25OHD was associated with IFG.
Conclusions: High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood.
Key Messages
- High serum 25OHD levels in youth, and between youth and adulthood, were associated with a lower risk of T2DM in adulthood.
- Each SD (15.2 nmol/L) increment in youth serum 25OHD levels was associated with a 26% reduction in odds for T2DM, which was independent of a number of confounding variables and other risk factors for T2DM. A similar magnitude of association was observed for the long-term 25OHD levels between youth and adulthood.
- These findings suggest a potentially simple and cost-effective strategy for reducing adulthood risk of T2DM starting in an earlier stage of life – improving and maintaining vitamin D status throughout youth and early adulthood.
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