Gout and Vitamin D - many studies

12 Reasons to believe that Gout is associated with low vitamin D


Reasons to believe that Gout is associated with low vitamin D

  1. Acute gouty arthritis is seasonal. 1998
    Increased by 32% in Spring (when vitamin D levels are the lowest)
  2. Clinical Trials for Gout and Vitamin D
    Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
    Good: 50,000 IU weekly, unfortunately: D2, not D3
  3. Vitamin D reduces Rheumatoid arthritis 118 items
  4. Vitamin D reduces Pain 167 items
  5. Vitamin D reduces Inflammation category listing with 175 items
  6. Higher incidence of gout with age (less vitamin D and gastric acid as you get older)
  7. Increased gout at higher Latitude (Gout and Goutiness a 1899 book
  8. Increased gout with soda pop
    JAMA study from 2010.2 women >2 cans of soda daily 2X more likely to develop gout (Note that soda decreases vitamin D levels)
  9. 2X more Gout if Dark Skin
    WikiPedia gout is twice as likely in African American males as it is in European Americans
  10. Gout and Calcium and vitamin D
    Calcium and Vitamin D. The relationship of gout to calcium and vitamin D is complex.
    Gout is associated with insulin resistance, low vitamin D levels, and inflammation, all of which interfere with muscle synthesis.
    One study has found that patients with gout have lower vitamin D3 levels correlated with higher urate.
  11. Increased gout recently (along with increased number of people being vitamin D deficient)- both blacks and whites
    New Zealand 2009 publication
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    Gout incidence has been increasing (while vitamin D has been decreasing)
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  12. Gout has increased, but appears to be correlated with obesity/ hypertension 2011
    note: both obesity and hypertension are associated with low vitamin D {FONT}

4X less likely to die of Gout if 40 ng of Vitamin D - Aug 2024

Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with gout and hyperuricemia
Nutrition Journal Volume 23, article number 89, https://doi.org/10.1186/s12937-024-00992-8
Ke Liu, Xuanni Lu, Anqi Wang, Weiwei Chen, Ying Chen, Jiayu Li, Xiaohui Sun, Lin Huang, Zhixing He, Chengping Wen, Yingying Mao & Ding Ye

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Background
We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA).

Methods
The study included 1169 gout patients and 7029 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 and 2001–2018, respectively. The association between serum 25(OH)D and mortality was evaluated by Cox proportional hazard and restricted cubic spline models.

Results
Among participants with gout and HUA, the weighted mean concentrations of serum 25(OH)D were 71.49 ± 30.09 nmol/L and 64.81 ± 26.92 nmol/L, respectively. Vitamin D deficiency occurred in 29.68% of gout patients and 37.83% of HUA patients.
During 6783 person-years of follow-up among gout patients, 248 all-cause deaths occurred, among which 76 died from cardiovascular disease (CVD) and 49 died from cancer.
1375 HUA patients were recorded for all-cause mortality during 59,859 person-years of follow-up, including 427 CVD deaths and 232 cancer deaths.
After multifactorial adjustment, per one-unit increment in natural log-transformed 25(OH)D was associated with lower risk of 55% all-cause mortality and 61% CVD mortality among gout patients, and a 45% reduced risk of cancer mortality among HUA patients.
Restricted cubic splines showed a U-shaped relationship with all-cause and CVD mortality among HUA patients, with inflection points of 72.7 nmol/L and 38.0 nmol/L, respectively. The results were robust in subgroup and sensitivity analyses.

Conclusions
Serum 25(OH)D was negatively linearly correlated with mortality among gout patients, whereas U-shaped correlated with mortality in HUA patients. These results indicate that adequate vitamin D status could prevent premature death.
 Download the PDF from VitaminDWiki

Vitamin D and Gout: Facts, etc.

FACT: Gout increases with age
FACT: Gastric Acid/digestion decreases with age
FACT: Coffee increases gastric acid
FACT: Coffee decreases gout (known since 1672)
FACT: Vitamin D increased digestion
FACT: Vitamin D decreases Gout
CONCLUSION: Improved digestion ==> reduced gout
Hypothesis: Other ways to Increase digestion, such as HCL or digestive enzymes, will also decrease gout
Note: Vitamin D reduces gout by at least the following ways:

  1. improving digestion
  2. improving kidney function
  3. reducing pain
  4. reducing inflammation

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See also VitaminDWiki


Many reasons why vitamin D deficiency has become epidemic which includes the following chart
http://www.vitamindwiki.com/tiki-index.php?page_id=1586
Gout has the following chart
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See also web

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Gout in the UK increased 20% in 3 years - Sept 2022

Victorian disease RETURNS to UK as NHS sees sudden surge and shares four warning signs Mirror
Also tuberculosis, malnutrition, whooping cough, measles, scurvy, typhoid, scarlet fever, diphtheria, mumps, rickets, cholera, and vitamin D deficiency

Gout, RA symptoms sometimes the same, sometimes different

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Gout epigenetics: Vitamin D, Vitamin D Receptor, Omega-3, etc - Sept 2022

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 Download the PDF from VitaminDWiki

7+ VitaminDWiki pages have GOUT in title

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