Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions
Renal Replacement Therapy (2018) 4:1 DOI 10.1186/s41100-017-0142-7
Ryota Ikee
Update: The emerging role of magnesium in CKD- Jan 2022 PDF
- Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
- Kidney disease requires magnesium - Jan 2013
- Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015
Magnesium and Vitamin D category contains the following summary
- Overview Magnesium and vitamin D
- Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
- The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
- Magnesium deficiency – causes and symptoms – May 2016
- Magnesium Depletion Score predicts increased risk of various health problems
- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium: intake decreased, difficult to measure in body – Sept 2018
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
- Magnesium is important for health but levels are low – July 2018
- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
- Magnesium etc. reduced in crops (must supplement) – 2009
Mg and Vitamin D
- Intracellular Magnesium and Vitamin D - a few studies
- Vitamin D and Magnesium need each other - many studies
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
- Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
- Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
- Vitamin D Cofactors in a nutshell
- Magnesium and Vitamin D - similar, different and synergistic
Magnesium topics gathered on a page
- Vitamin D, Omega-3, and Magnesium are synergistic - many studies
- Magnesium and Cancer - many studies
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Low Magnesium associated with severe COVID – many studies
- Calcium to Magnesium Ratio - many studies
- Magnesium Role in Health and Longevity - many studies
- Magnesium reduces pain - many studies
- Vitamin D and Magnesium need each other - many studies
- Pregnancy helped by Magnesium - many studies
Download the PDF from VitaminDWiki
Magnesium (Mg) is an essential element that plays pivotal roles in a number of biological processes in the human body. Hypomagnesemia is involved in the pathophysiology of hypertension, vascular calcification, and metabolic derangements including diabetes mellitus and dyslipidemia, which are all risk factors for cardiovascular disease, the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD).
Hypomagnesemia is also associated with the development and progression of CKD. As CKD advances, renal Mg excretion decreases and hypermagnesemia emerges in end-stage renal disease (ESRD). In addition, dialysates with high Mg concentrations, which were used in the early era of dialysis therapy, increased the risk of hypermagnesemia, and thus, the dialysate Mg composition has since been reduced. Accordingly, dialysis patients in the modern era commonly have normomagnesemia or even hypomagnesemia.
The relationships between hypomagnesemia and cardiovascular disease and mortality have been increasingly reported in observational studies in CKD/ESRD. However, these relationships may be attenuated by a patient's race or region.
Although dialysates with higher Mg concentrations or Mg-containing phosphate binders appear to be promising in this setting, only a few interventional studies have examined the effects of Mg supplementation on cardiovascular lesions. Furthermore, the effects of Mg supplementation on mortality have not yet been investigated as a primary end-point in randomized controlled trials. Further studies are required in order to establish the efficacy and safety of Mg in CKD patients.
| 3934 visitors, last modified 04 Aug, 2022, |