Vitamin D deficiency: a new risk factor for type 2 diabetes?.
Ann Nutr Metab. 2012;61(4):337-48. doi: 10.1159/000342771. Epub 2012 Dec 3.
Mezza T, Muscogiuri G, Sorice GP, Prioletta A, Salomone E, Pontecorvi A, Giaccari A.
Endocrinologia, Università Cattolica del Sacro Cuore, Roma, Italia. teresa.mezza@gmail.com
Recent compelling evidence suggests a role of vitamin D deficiency in the pathogenesis of insulin resistance and insulin secretion derangements, with a consequent possible interference with type 2 diabetes mellitus. The mechanism of this link is incompletely understood. In fact, vitamin D deficiency is usually detected in obesity in which insulin resistance is also a common finding. The coexistence of insulin resistance and vitamin D deficiency has generated several hypotheses. Some cross-sectional and prospective studies have suggested that vitamin D deficiency may play a role in worsening insulin resistance; others have identified obesity as a risk factor predisposing individuals to exhibit both vitamin D deficiency and insulin resistance. The available data from intervention studies are largely confounded, and inadequate considerations of seasonal effects on 25(OH)D concentrations are also a common design flaw in many studies. On the contrary, there is strong evidence that obesity might cause both vitamin D deficiency and insulin resistance, leaving open the possibility that vitamin D and diabetes are not related at all. Although it might seem premature to draw firm conclusions on the role of vitamin D supplementation in reducing insulin resistance and preventing type 2 diabetes, this manuscript will review the circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity.
Copyright © 2012 S. Karger AG, Basel.
PMID: 23208163
PDF is attached at the bottom of this page
See also VitaminDWiki
- African-Americans at high risk of obesity and diabetes - 2011
- Diabetes 6X more likely for those abdominal obese who have insufficient vitamin D – June 2012
- Obesity lowers vitamin D which increases probability of diabetes in children – Nov 2011
- Obesity and diabetes reduced when move to better neighborhood – or better UV – Oct 2011
- Overview Diabetes and vitamin D
- Overview Metabolic Syndrome and vitamin D