Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues.
Autoimmun Rev. 2018 Jan 15. pii: S1568-9972(18)30011-9. doi: 10.1016/j.autrev.2018.01.004. [Epub ahead of print] Stagi S1, Rigante D2.
- 1 Health Science Department, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy. stefano.stagi@yahoo.it.
- 2 Institute of Pediatrics, Fondazione Policlinico Universitario "A. Gemelli", Università Cattolica Sacro Cuore, Rome, Italy.
- Lupus is both prevented and treated by Vitamin D – review Dec 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- It is time to routinely give vitamin D to Lupus patients – Dec 2016
- Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015
- Lupus is yet again strongly associated with low vitamin D (when will supplementation be tried) -Dec 2014
- Lupus again found to be related to vitamin D deficiency - should supplementation start? – May 2010
Wonder how many more years it will be before Vitamin D will routinely be used to treat Lupus
Suspect that Lupus specialists do not want to experience a decrease in a need for their services - Lupus helped by Vitamin D supplementation in 3 out of 4 studies – Oct 2017
- Lupus category listing has
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Systemic lupus erythematosus (SLE) and juvenile SLE (jSLE) are autoimmune disorders naturally associated with several genetic, environmental, hormonal, and immunological contributing factors.It has been assumed that vitamin D deficiency may have a role in the immune activation of patients with SLE and play an active part in many comorbidities and even complications. A host of clinical studies suggested that vitamin D exerts inhibitory effects on many immunological abnormalities associated with SLE, also in children and adolescents, while different reports have hypothesized that vitamin D may be associated with accelerated cardiovascular disease in SLE.
This review updates and summarizes the information related to the immunoregulatory effects of vitamin D and its importance in jSLE, discusses the innumerable correlations between vitamin D and disease activity, including clinical expression and gene polymorphisms of vitamin D receptor as well as the recommendations for vitamin D supplementation in these patients.
Despite the excitement raised by many data obtained about vitamin D and its influence on several aspects of the disease, further well-designed perspective trials are required to define the exact role that vitamin D may have in the management of both SLE and jSLE.
PMID: 29353100 DOI: 10.1016/j.autrev.2018.01.004
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