Vitamin D and cutaneous lupus erythematosus: effect of vitamin D replacement on disease severity
CLE =cutaneous lupus erythematosus = 3.5 X more chance of Vitamin D deficiency
Cutaneous Lupus Erythematosus Disease Area and Severity Index
- Before: 0.9
- After 1 year: 2.7
Oral vitamin D3 was recommended to cases who attended our clinic in June and July 2008, and who did not present optimal levels of 25(OH)D at or above 30 ng/ml.
They were placed in the following oral vitamin D supplementation schedule: 1400 IU of cholecalciferol, plus 1250 mg of calcium carbonate, per day for 40 days, followed by a tablet twice a day of a fixed combination of 1250 mg of calcium carbonate and 400 IU of cholecalciferol for one year of treatment, according to drug labeling.
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E Cutillas-Marco 1
A Marquina-Vila 2
WB Grant 3
JJ Vilata-Corell 4
MM Morales-Suárez-Varela 5,6,7
1Department of Dermatology, Hospital de la Vega Lorenzo Guirao, Murcia, Spain
2Department of Dermatology, Hospital Universitario Doctor Peset, Valencia, Spain
3Sunlight, Nutrition, and Health Research Center, California, USA
4Department of Dermatology, Hospital General Universitario de Valencia, Spain
5CIBER Epidemiología y Salud Pública (CIBERESP), Spain
6Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain
7Centre for Public Health Research (CSISP), Spain
Eugenia Cutillas-Marco, Hospital de la Vega Lorenzo Guirao, Department of Dermatology, Carretera de Abarán, s/n, 30530 Cieza, Murcia, Spain. Email: ecutillas@aedv.es
Background The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE).
Objectives The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration on disease severity.
Methods Vitamin D status in 60 CLE patients and 117 apparently healthy subjects was compared. We recommended oral vitamin D3 to 27 CLE patients. After one year of treatment, changes in disease severity were assessed and compared to 25 untreated CLE patients. Disease severity was measured by the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), number of exacerbations, duration of active lesions and patient assessment.
Results Presence of CLE raised the odds of having vitamin D deficiency (OR 3.47, 95% CI 1.79–6.69). Increasing age and disease duration were associated with higher odds of having vitamin D deficiency.
After a one-year follow-up, disease activity improved in the treatment group (CLASI A 2.7 ± 2.9 vs. 0.9 ± 1.4) (p = 0.003), as confirmed by the patient assessment (p = 0.01).
Conclusions Vitamin D inadequacy is more prevalent in CLE participants than in healthy controls.
Treating vitamin D insufficiency is associated with improved disease severity according to physician and patient assessments.
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Would really like to know how much Vitamin D was used in the intervention
3X better = 2.7 / 0.9
See also VitaminDWiki
- Lupus category listing with
78 items - Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
- Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
- Lupus is yet again strongly associated with low vitamin D (when will supplementation be tried) -Dec 2014
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