25-Hydroxyvitamin D serum levels and melanoma risk: a case-control study and evidence synthesis of clinical epidemiological studies.
Eur J Cancer Prev. 2018 Feb 12. doi: 10.1097/CEJ.0000000000000437. [Epub ahead of print]
Cattaruzza MS1, Pisani D2, Fidanza L3, Gandini S4, Marmo G3, Narcisi A3, Bartolazzi A5,6, Carlesimo M3.
- Cancer - Skin category listing has
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items along with related searches
- Melanoma associated with vitamin D less than 30 ng (9X) – March 2021
- People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D – Dec 2016
- Melanoma huge increase - perhaps due to use of sunscreen or lower vitamin D - Aug 2014
- Overview Suntan, melanoma and vitamin D
- Melanoma is 44 percent LESS LIKELY if get sun on the job – Nov 2013
- Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020
See also web
Note: Virtually no melanoma for Vitamin D levels > 40 ng, which is easily obtained
Download the PDF from Sci-Hub via VitaminDWiki
There is accumulating evidence that the vitamin D pathway may play a role in melanoma. The aim of this study was to investigate the association between 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of cutaneous melanoma.
A case-control study with 137 incident cases of melanoma (serum samples collected at the time of diagnosis) and 99 healthy controls (serum samples collected between October and April) was carried out and evaluated in the framework of an evidence synthesis of clinical epidemiological studies on the topic to facilitate comparisons and summarize the scientific evidence produced so far.
There was a statistically significant difference in the median levels of serum vitamin D between melanoma patients and healthy controls (18.0 vs. 27.8 ng/ml, P<0.001). Among melanoma patients, 66.2%, compared with 15.2% of healthy controls, had vitamin D deficiency (≤20 ng/ml), whereas vitamin D sufficiency (≥30 ng/ml) was observed in only 7.4% of melanoma patients and in 37.4% of the healthy controls (P<0.001).
A multivariate model including age, sex, and BMI showed a statistically significant inverse association between melanoma and vitamin D sufficiency versus deficiency (odds ratio=0.04; 95% confidence interval: 0.02-0.10, P<0.001).
Also, vitamin D insufficiency versus deficiency was significantly inversely associated with melanoma (odds ratio=0.13; 95% confidence interval: 0.06-0.27, P<0.001).
These results suggest that both deficient and insufficient serum levels of vitamin D are associated with melanoma and that a trend seems to be present with a reduced risk of melanoma when vitamin D approaches normal values.
PMID: 29438161 DOI: 10.1097/CEJ.0000000000000437
Study was reported on by Grassroots Health in June 2018
GRH
VitaminDWiki pages with MELANOMA in title (41 as of Jan 2022)
This list is automatically updated
Items found: 46
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Melanoma risk reduced by Vitamin D and other nutrients - 2023 |
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27 Jun, 2024 |
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Melanoma death risk 0.63 X lower if poor Vitamin D Binding Gene – July 2023 |
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26 Aug, 2023 |
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Metastatic Melanoma survived 2X longer if adequate level of Vitamin D – July 2023 |
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03 Aug, 2023 |
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Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis May 2023 |
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18 May, 2023 |
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Melanoma might be suppressed by Vitamin D - many studies |
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25 Nov, 2022 |
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Melanoma Cancer detected more often (perhaps due to infrequent intense UVA) – Oct 2022 |
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07 Oct, 2022 |
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Overview Suntan, melanoma and vitamin D |
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28 Nov, 2021 |
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Melanoma not treated by small doses of vitamin D (100,000 IU every 50 days) – RCT June 2021 |
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30 Jun, 2021 |
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Melanoma huge increase - perhaps due to use of sunscreen or lower vitamin D - Aug 2014 |
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26 Apr, 2021 |
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Melanoma associated with vitamin D less than 30 ng (9X) – March 2021 |
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13 Mar, 2021 |
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Recurrence of malignant melanoma may be reduced by 100,000 IU of vitamin D monthly – trial underway 2017 |
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13 Mar, 2021 |
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Melanoma 25 X more likely if low vitamin D – Feb 2018 |
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13 Mar, 2021 |
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Sunlight on skin has decreased 9X while melanoma has increased 30X – Feb 2020 |
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20 Feb, 2020 |
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Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 |
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11 Jan, 2020 |
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Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 |
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06 Nov, 2019 |
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Melanoma Is a Disease of Office Workers - Dec 2018 |
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12 Dec, 2018 |
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Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018 |
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20 Nov, 2018 |
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UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017 |
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09 Oct, 2017 |
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Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017 |
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23 May, 2017 |
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Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 |
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27 Jan, 2017 |
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People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D – Dec 2016 |
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31 Dec, 2016 |
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Vitamin D being considered for Melanoma – active vitamin D is produced by skin – Nov 2016 |
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01 Dec, 2016 |
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Melanoma survival doubled with Vitamin D binding protein polymorphism – Nov 2015 |
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18 Nov, 2015 |
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Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 |
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24 Oct, 2014 |
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Melanoma REDUCED by those getting the most UV, unless 5 blistering sunburns while in teen years – June 2014 |
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05 Jun, 2014 |
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Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 |
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28 May, 2014 |
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Melanoma and Vitamin D genes - multiple papers |
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22 Mar, 2014 |
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Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 |
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22 Mar, 2014 |
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Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 |
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19 Mar, 2014 |
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Decreased risk of non-melanoma skin cancer by working outdoors in Europe – April 2013 |
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22 Dec, 2013 |
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UV and Melanoma: are they related – 2013 |
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19 Dec, 2013 |
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The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer - Nov 2013 |
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14 Dec, 2013 |
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Melanoma is 44 percent LESS LIKELY if get sun on the job – Nov 2013 |
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01 Dec, 2013 |
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Melanoma not as thick if recently had a sunny vacation – Nov 2013 |
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14 Nov, 2013 |
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UVA most likely causes melanoma to progress– Sept 2011 |
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10 Nov, 2013 |
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Prostate Cancer increased melanoma rate by 2X (vitamin D not mentioned) Nov 2013 |
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09 Nov, 2013 |
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Melanoma and Vitamin D - association is not certain - 2012 |
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14 Jul, 2013 |
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Melanoma reduces by half the amount of vitamin D activated by the skin – March 2013 |
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17 Apr, 2013 |
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Melanoma less likely when far from equator – Oct 2012 |
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07 Dec, 2012 |
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Red-haired mice can get melanoma without UV - Oct 2012 |
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29 Nov, 2012 |
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Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011 |
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17 Oct, 2012 |
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Sun exposure is associated with increased survival from melanoma – 2005 |
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07 Oct, 2012 |
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No association found between melanoma and low vitamin D levels – Sept 2012 |
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12 Sep, 2012 |
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UVB, Smoking and second cancers after melanoma – Jan 2012 |
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06 Mar, 2012 |
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Perhaps 28-40 ng of vitamin D would be good for Melanoma patients – Feb 2011 |
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06 Mar, 2011 |
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Study Suggests Indoor Tanning Boosts Chances of Melanoma |
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27 May, 2010 |