The New Science of Disease Recovery Atlantic
- “They have divided the immune response into two basic categories: the traditional part, dubbed resistance, which fights the pathogen itself; and the less-studied part, called tolerance, which aims to curb or repair the damage . . . “
- predict whether malaria-infected mice would live or die – based on % of immature red blood cells
- “In the lab, about 20 percent of a genetically identical group of mice will die if infected with malaria.”
VitaminDWiki notes that this is similar to the 20% of people who get symptoms after being bitten by mosquitoes carrying Zika, Dengue, etc, - “Children with the sickle-cell trait, who are more resilient to the infection, have ratios of red blood cells that mimic those of the resilient mice.”
Reticulocyte Wikipedia
- “Reticulocytes are immature red blood cells,”
- . . “0.5% to 2.5% in adults and 2% to 6% in infants”
- “The number of reticulocytes is a good indicator of bone marrow activity. . . “
Test for Reticulocytes
Wonder if Vitamin D increases the body’s ability to repair damage of various diseases = Tolerance
See also VitaminDWiki
- Vitamin D and malaria – many studies
- Severe malaria 9 percent less likely with each extra 1 nanogram of vitamin D – 2014
- 5X more likely to be vitamin D deficient if anemic - Dec 2012
Items in both categories of Bone Health and Dark Skin are listed below
- Vitamin D should be an almost universal feature of the care of young adults with sickle cell disease – May 2018
- Vitamin D paradox – Blacks need Vit D for health, but not as much D for strong bones – May 2018
- Sickle Cell clinical trial will inject 300,000 IU of vitamin D – RCT due 2020
- Sickle Cell children need more than 7,000 IU of vitamin D daily – May 2015
- Overview Sickle Cell and Vitamin D
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Bone density does not decrease with lower vitamin D levels in blacks as it does in whites – April 2014
- Vitamin D different relationship between whites and blacks for bone and plaque – June 2012
- Sickle cell and low vitamin D – 3 presentations Dec 2012
- Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012
- Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D – April 2012
- Black seniors near equator: increased vitamin D decreases bone density – Sept 2011
- 14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain
- Blacks may not need as much Vitamin D (for their bones)
- Low vitamin D before orthopedic surgery – dark skin 5X more likely – Oct 2010
- Arthritis 2X as severe in African-Americans - April 2010