Pain sources vs. Vitamin D - Jan 2025

Baseline Vitamin D Levels on Quality of Life and Pain Perception Among Patients with Chronic Pain with Long-Term Prescription Opioid Use: A Prospective Study

J. Clin. Med. 2025, 14(2), 645; https://doi.org/10.3390/jcm14020645
by Gabija Laubner Sakalauskienė 1,*ORCID,Indrė Stražnickaitė 2ORCID,Sigutė Miškinytė 2ORCID,Linas Zdanavičius 2ORCID,Jūratė Šipylaitė 1 andRobertas Badaras 1
1 Clinic of Anaesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania
2 Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania

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Objectives: To investigate the correlation between baseline serum concentrations of 25-hydroxyvitamin D (25-OHD) and quality of life (QoL), as well as pain perception in patients with chronic pain with long-term prescription opioid usage before opioid detoxification. Methods: We prospectively studied 45 patients with chronic pain with long-term prescription opioid usage who were selected for elective detoxification. Baseline serum 25-OHD levels were measured prior to detoxification, classifying patients as either vitamin D deficient (<75 nmol/L) or sufficient (≥75 nmol/L). QoL was assessed using the SF-36v2TM questionnaire, while pain levels were assessed using Visual Analogue Scale (VAS) scores before treatment. Results: Mean pain scores before detoxification of the patients with sufficient baseline 25-OHD levels vs. those with deficient levels were, respectively, 6.06 ± 2.32 vs. 6.86 ± 2.10 (normalized scores 1.22 ± 0.571 vs. 0.950 ± 0.632; p = 0.164). The analysis of SF-36v2™ questionnaire scores revealed minimal variation between groups (35.00 ± 14.198 vs. 34.97 ± 13.52), indicating no significant association between Vitamin D levels and QoL (p = 0.913). Conclusions: The analysis of baseline 25-OHD levels in relation to QoL assessments and pain scores did not reveal a statistically significant association, indicating that variations in baseline vitamin D levels may not substantially impact QoL or pain perception. Further studies may help determine how to assess and optimize vitamin D levels in patients with chronic pain on long-term prescription opioids.
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  1. Overview Pain and Vitamin D
  2. Percentage of people with pain increased 25 percent in 18 years – Jan 2019
  3. Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
  4. Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023
  5. Vitamin D may influence pain intensity – review Nov 2024
  6. Growing pains associated with low Vitamin D - many studies
  7. Vitamin D reduces 5 types of chronic pain
  8. Pain relieved by Vitamin D if trial lasted more than 5 months (endometriosis, 50K weekly for 12 months) – Aug 2023
  9. Long-term neck and back pains greatly reduced by 50,000 IU of Vitamin D – 4 cases – Sept 2019

24+ VitaminDWiki pages have both PAIN and RCT in their title

This list is automatically updated

Items found: 24
Title Modified
Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 27 Aug, 2023
Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023 22 Jul, 2023
Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012 17 Jul, 2023
Menstrual Pain (PMS) reduced by vitamin D – RCT 2012, 2014, 2016 23 Sep, 2021
Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020 25 Jul, 2020
Lower back pain treated by 600,000 IU of Vitamin D – RCT June 2019 28 Jun, 2019
Knee pain and depression reduced by monthly 50,000 IU vitamin D – RCT April 2018 21 Apr, 2018
Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018 02 Mar, 2018
Can burn pain be relieved by 4 g of Omega-3 and 2,000 IU of vitamin D – RCT due 2021 18 Oct, 2017
Long-term lower back pain greatly reduced by Magnesium - RCT 2013 29 May, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Raynaud's pain decreased with 20,000 IU daily average vitamin D – RCT May 2012 05 Dec, 2016
Less use of musculoskeletal pain drugs if get vitamin D (no dose information)– RCT Feb 2015 20 Nov, 2016
Menstrual Pain reduced by vitamin D – RCT Feb 2012 07 May, 2016
Back pain not relieved when vitamin D levels remained below 30 nanograms – RCT Nov 2015 04 Dec, 2015
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 05 Nov, 2015
Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015 05 Nov, 2015
Pain not reduced by vitamin D (only used 1,000 IU) - RCT Dec 2014 16 Jul, 2015
Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012 24 May, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 22 Nov, 2014
Dark skinned in Norway: 1000 IU vitamin D not enough to reduce pain – RCT Sept 2014 28 Sep, 2014
150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012 17 Sep, 2014
Pain reduction with 600,000 IU Vitamin D: RCT announced Dec 2013 06 Dec, 2013
Just 500 IU of vitamin D helped reduce rheumatoid arthritis pain - RCT Oct 2011 07 Sep, 2012
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