People with spinal cord injury also very vitamin D deficient – 2010

Influence of season, ethnicity, and chronicity on vitamin D deficiency in traumatic spinal cord injury.

J Spinal Cord Med. 2010;33(3):202-13.
Oleson CV, Patel PH, Wuermser LA.
Department of Rehabilitation Medicine, Birmingham School of Medicine, University of Alabama at Birmingham, Alabama, USA. christina.oleson@jefferson.edu

BACKGROUND: Inadequate levels of vitamin D increase the risk of osteoporosis, a highly prevalent condition in patients with traumatic spinal cord injury (SCI). Reduced sunlight and dark skin further contribute to low vitamin D levels.

OBJECTIVES: To compare serum 25-hydroxy vitamin D [vitamin D25(OH)] levels in acute and chronic SCI and to explore seasonal and ethnic differences among patients with acute and chronic SCI.

PATIENTS/METHODS: Patients (N=96) aged 19 to 55 years with C3-T10 motor complete SCI participated. Acute SCI was 2 to 6 months after injury, whereas chronic SCI was at least 1 year from injury. Serum vitamin D25(OH), calcium, and parathyroid hormone were drawn dUring summer or winter months. Vitamin D deficiency (<13 ng/mL), insufficiency (<20 ng/mL), and subtherapeutic (<32 ng/mL) levels were compared for all groups. A 3-way analysis of covariance was adopted to determine significant main effects of season, chronicity, and ethnicity. Interactions between season and chronicity, season and ethnicity, and chronicity and ethnicity were evaluated. Evaluation of a 3-way interaction among season, chronicity, and ethnicity was completed.

RESULTS: In summer, 65% of patients with acute SCI and 81% of patients with chronic SCI had subtherapeutic vitamin D levels, whereas in winter, 84% with acute SCI and 96% with chronic SCI had vitamin D25(OH) (<32 ng/mL). Lower vitamin D25(OH) levels were observed in African Americans relative to whites. Significant main effects were noted for season (P = 0.017), chronicity (P = 0.003), and ethnicity (P < 0.001). However, interactions between 2 or more factors were not found.

CONCLUSIONS: Vitamin D insufficiency and deficiency are found in the majority of patients with chronic SCI and in many with acute SCI. Initial screening for serum vitamin D25(OH) levels should be performed early in rehabilitation. Periodic monitoring in the chronic setting is highly recommended. PMID: 20737793
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See also VitaminDWiki

• 93% of Spinal cord injury patients were low on vitamin D March 2010
• Spinal Cord Injury patients normalized by 2,000 IU of vitamin D for 3 months – Sept 2011
• All items in category Spinal Cord 21 items
• Vitamin D repaired nerve in rat (50,000 IU daily dose equivalent for human) – June 2013