Effect of Vitamin D3 Supplementation on Insulin Sensitivity in Prediabetes With Hypovitaminosis D: A Randomized Placebo-Controlled Trial
Cureus. 2020 Dec 10;12(12):e12009. doi: 10.7759/cureus.12009.
Munibuddin M Ahmed 1, Urjita S Zingade 2, Khaled M Badaam 1
Vitamin D levels 10 ng ==> 52 ng after 12 weeks with improved insulin sensitivity
Diabetes and non-daily intervention
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020
- 100,000 IU of Vitamin D3 monthly for 4 months to diabetics (D2 bombed) – RCT Dec 2019
- Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- 50,000 IU Vitamin D weekly Improves Mood, Lowers Blood Pressure in Type 2 Diabetics – Oct 2013
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
551 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 56 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 29 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Diabetes category starts with the following
551 items In Diabetes category 34+ Prediabetes studies 64+ Type 1 Diabetes studies see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has204 items along with related searches
- Prediabetes both prevented and treated by monthly Vitamin D, etc.
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Download the PDF from VitaminDWiki
Introduction The interplay of vitamin D and glucose metabolism is an area of ongoing research. The need for vitamin D supplementation trials in individuals with prediabetes and hypovitaminosis D has been stressed by earlier research studies. The objective of this study was to assess the effect of vitamin D3 supplementation on oral glucose insulin sensitivity (OGIS) index in patients with prediabetes and hypovitaminosis D.
Methods We enrolled 120 individuals with prediabetes (ADA definition) and hypovitaminosis D (vitamin D < 30 ng/mL) and randomized them into the vitamin D supplementation (60,000 IU weekly) group and the placebo group. Primary outcome measure (i.e., 2-hour OGIS index) and secondary outcome measures (i.e., fasting and postprandial blood glucose, glycosylated hemoglobin, body mass index, and insulin sensitivity indices, i.e., quantitative insulin sensitivity check index [QUICKI] and homeostatic model assessment for insulin resistance [HOMA-IR]) were analyzed for change with the 12 weeks of intervention.
Results A total of 52 subjects in the vitamin D group and 49 in the placebo group completed the study. Serum vitamin D levels (10.11 ± 2.73 to 52.2 ± 13.14 ng/mL; p < 0.0001) and OGIS index (376.4 ± 39.7 to 391.7 ± 40.7 mL/min/m2; p = 0.011) increased significantly on per-protocol analysis in the vitamin D group. There was no significant change observed in vitamin D levels and OGIS index in the placebo group. Between-group comparison showed a rise in OGIS index (15.3 ± 47.1 mL/min/m2) in the vitamin D group and decrease in OGIS index (-10.4 ± 44.7 mL/min/m2) in the placebo group, and the difference was statistically significant (p = 0.0029). The inter-group comparison showed relative fall in fasting glucose levels in the vitamin D group, with no significant change observed in the other secondary outcome measures.
Conclusions The correction of hypovitaminosis D in subjects with prediabetes led to improved insulin sensitivity as assessed by OGIS index at 120 minutes, signifying the role of vitamin D in glucose homeostasis.
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