Most responses to daily oral Vitamin D plateau in 2 or 3 months
Grassroots Health
Perhaps much slower response time if person is not healthy/ is needing lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception has the following
Vitamin D Levels Plateau typically in 11 weeks (Vitamin D starts to help in about half that time)
- Defining normal level of vitamin D (need 4000-5000 IU) - Heaney Spring 2013 11 weeks
- Vitamin D every 25 days may be BETTER than daily – RCT May 2018 > 11 weeks
- 3 to 6 months to plateau with 4,000 IU vitamin D daily (Cardiac Patients) – June 2017 14? weeks
- Pregnancy 20 weeks
- 35,000 IU vitamin D weekly during 3rd quarter pregnancy – RCT March 2013 4 weeks if pre-load
70,000 IU pre-load +35,000 IU weekly dose
Many Vitamin D trials last 3 months or less
However, sometimes responses do not plateau for 4-12 months
No one seems to know why some people respond slowly
Slow responses might be due to differences in
- Genetics – activation of genes can change over months
- Note: Activation/deactivation of 6 genes is not noticed by a vitamin D blood test
- Age
- Approximately 10% of people are NON-RESPONDERS
Wonder how many non-responders are actually just slow responders - Pre-existing conditions – such as removed gallbladder, poor liver or kidney
- Gut adjustment – may take many months for gut bacteria to become efficient at absorbing Vitamin D
- Initial Vitamin D level
Suspect a different response time if start at low vs high level of vitamin D - Compliance increased AFTER person notices benefit
- Reduced some drugs, smoking, stress, etc after getting benefit from vitamin D ==> which increased Vitamin D levels in body
- Obesity
Example Heaney 2003: 38 years old, healthy, men
Doubt that the response is the same for:
very young, very old, unhealthy, females, starting with >50 ng or < 10 ng, etc.
A loading dose increases Vitamin D levels 30X faster
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses
TOP articles in Loading Dose of Vitamin D
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before most surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
10,000 IU of Vitamin D for 7 years with no excessive Calcium in 4,800 patients – Dec 2018
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