Chinese Critical Care Medicine, 31 (9), 1170-1173 Sep 2019, doi: 10.3760/cma.j.issn.2095-4352.2019.09.024
. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, Chen Yang 1, Yu Liu, Wenhui Wan wanwhnj@sina.com.
Department of Geriatrics, Eastern Theater General Hospital, Nanjing 210002, Jiangsu, China.
Sepsis is both prevented and treated by Vitamin D - many studies starts with
- Sepsis is more likely in those with poor immune systems
Infants, the elderly, the sick, and those with low vitamin D - Severe sepsis has been associated with low Vitamin D and poor Vitamin D receptor in many studies
- Loading doses of Vitamin D bypass any poor Vitamin D Receptors
- Vitamin D loading doses have been proven to treat sepsis (RCTs: 2015, 2020, 2021)
Reduced: ICU stay by 8 days, Hospital stay by 7 days, and readmission rate reduced to 0%
Note: The fastest way (2 hours) to have a sublingual loading dose of Vitamin D nano-emulsion - Sepsis is fought by Vitamin D in 9 ways – Feb 2023
Sepsis is a life-threatening organ dysfunction caused by the host's imbalance in response to infection, which is still the leading cause of death in critically ill patients. In recent years, studies have found that vitamin D deficiency or insufficiency is common in critically ill patients, especially sepsis. The relationship between vitamin D and sepsis has attracted more and more attention.
The mechanism of vitamin D in sepsis is described from the aspects of
- immune regulation,
- inflammation regulation,
- endothelial cell protection,
- carbon monoxide regulation, and
- receptor gene polymorphism,
by analyzing the related literatures of vitamin D and sepsis in recent years in order to provide new ideas for clinical diagnosis and treatment of sepsis.