Seniors taking vitamin D were 40% less likely to get dementia - Jan 2023

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Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status

Alzheimer’s Dement. 2023; https://doi.org/10.1002/dad2.12404
Maryam Ghahremani, Eric E. Smith, Hung-Yu Chen, Byron Creese, Zahra Goodarzi, Zahinoor Ismail

Highlights

• In a prospective cohort study, we assessed effects of Vitamin D on dementia incidence in 12,388 participants from the National Alzheimer's Coordinating Center dataset.
• Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure.
• Vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment.
• Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers.
• Vitamin D has potential for dementia prevention, especially in the high-risk strata.

Introduction
Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.

Methods
Baseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves compared dementia-free survival between groups. Cox models assessed dementia incidence rates across groups, adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Sensitivity analyses examined incidence rates for each vitamin D formulation. Potential interactions between exposure and model covariates were explored.

Results
Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55–0.65). The effect of vitamin D on incidence rate differed significantly across the strata of sex, cognitive status, and APOE ε4 status.

Discussion
Vitamin D may be a potential agent for dementia prevention.
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See Dementia is associated with low vitamin D - many studies

• Dementia again associated with low Vitamin D – 15th study in 10 years – Jan 2023

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VitaminDWiki - 14 studies in both categories Seniors and Cognitive

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