Relationship Between Vitamin D Status and Viral Pneumonia in Children
Pediatric Allergy, Immunology, and Pulmonology. June 2017, 30(2): 86-91. https://doi.org/10.1089/ped.2017.0750
- Less Pneumonia in those having more activated vitamin D (kidneys working)– April 2014
- Search VitaminDWiki for pneumonia 508 hits as of June 2017
- Pneumonia acquired in hospital – 3X more likely to die if low vitamin D – June 2015 seniors
- Children with pneumonia in Ethiopia were 22X more likely to have rickets – 1997
Both are associated with low vitamin D
Pages listed in BOTH the categories Breathing and Infant/Child
Low vitamin D in children is associated with a wide range of breathing problems
- 3X reduction in respiratory infections in children taking more than 800 IU of Vitamin D weekly – Nov 2024
- Risk of childhood pneumonia reduced 30% by high Vitamin D - Oct 2024
- Bronchopulmonary dysplasia, in a third of preemies, 87% reduced risk for just 1 ng higher Vitamin D level – Oct 2024
- Infant respiratory distress reduced by Vitamin D – meta-analysis July 2024
- Vitamin D levels are low during Recurrent Wheezing - Feb 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023
- Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023
- Respiratory infection, children and Vitamin D - many studies
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- RSV kills 100,000 children annually around the world (Vitamin D can help)– May 2022
- Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022
- Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022
- Wheezing and asthmatic children have weaker Vitamin D responses - May 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021
- The 6 percent of infants hospitalized for ARI are 2.2 X more likely to be Vitamin D deficient – April 2021
- Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021
- Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020
- Recurrent Wheezing in children is associated with low Vitamin D – several studies
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Gene which predicts wheezing is associated with low vitamin D – Oct 2019
- Bronchiolitis in children associated with both pollution and low solar – July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Immature lungs in immature newborns – Vitamin D helps – Sept 2018
- Bronchiolitis had 1.3 X longer hospitalization if low Vitamin D (1016 infants) – Sept 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018
- Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Rapid newborn breathing (transient tachypnea) associated with low vitamin D – Dec 2017
- Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017
Lin-Ying Guo, MD,1 Wei Li, MD,1 Xian-Fen Cheng, MD,2 Hong-Ri Li, MD,1 Chun-Rong Sun, MD,2 Jing Guo, MD,1 Guo-Wei Song, MD,1 Xiao-Dai Cui, MD,2 and Qi Zhang, MD1 zhangqi0355@sina.com
1 Intensive Care Unit, Affiliated Children's Hospital of Capital Institute of Pediatrics, Beijing, China.
2 Central Laboratory, Capital Institute of Pediatrics, Beijing, China.
This study investigated the impact of vitamin D status on the susceptibility and severity of viral pneumonia (VP) in children. A total of 236 children with VP, aged from 1 month to 14 years, and 271 gender and age matched healthy children to compare the serum 25(OH)D levels and vitamin D status. Vitamin D indices were compared between subgroups in VP cases. The median [interquartile range (IQR)] serum 25(OH)D level in these 507 children was 23.7 (IQR 17.5–30.6) ng/mL; 134 (26.4%) children were vitamin D sufficient [25(OH)D ≥30 ng/mL], whereas 373 (73.6%) were insufficient, which included insufficient [25(OH)D 20–30 ng/mL], deficient [25(OH)D 10–20 ng/mL], and severely deficient [25(OH)D ≤10 ng/mL]. The median (IQR) serum 25(OH)D level in the VP group was significantly lower than that in the control group [19.6 (12.3–26.4) ng/mL versus 26.6 (21.4–32.9) ng/mL] (P < 0.001).
The proportions of vitamin D deficiency (32.2% versus 19.5%) and severe deficiency (19.1% versus 0.4%) in the VP group were significantly higher than those in the control group (P < 0.001).
As vitamin D status decreased, the odds ratio (95% confidence interval) for VP showed an increasing trend [sufficiency (0.3; 0.2–0.5), insufficiency (0.9; 0.6–1.3), deficiency (2.0; 1.3–2.9), and severe deficiency (51.7; 7.2–372.2)].
The median (IQR) serum 25(OH)D level in the VP subgroup who accepted mechanical ventilation was significantly lower than that in the nonmechanical ventilation subgroup [12.9(6.5–22.5) ng/mL versus 20.8 (14.2–28.0) ng/mL] (P < 0.001).
Poor vitamin D status might be related to the susceptibility and severity of VP in children.