Vitamin D and Aging: Central Role of Immunocompetence – Carlberg Jan 2024

The Study

Nutrients 2024, 16(3), 398; https://doi.org/10.3390/nu16030398
Carsten Carlberg 1,2,*ORCID and Eunike Velleuer 3,4ORCID
1 Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, PL-10-748 Olsztyn, Poland
2 School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland
3 Department for Cytopathology, Heinrich-Heine-University Düsseldorf, D-40225 Düsseldorf, Germany
4 Department for Pediatric Hemato-Oncology, Helios Children’s Hospital, D-47805 Krefeld, Germany

(This article belongs to the Section Nutrigenetics and Nutrigenomics)
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The pro-hormone vitamin D3 is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates via the transcription factor VDR (vitamin D receptor) the epigenome and transcriptome of human immune cells and controls in this way the expression of hundreds of vitamin D target genes. Since the myeloid linage of hematopoiesis is epigenetically programmed by VDR in concert with the pioneer factors PU.1 (purine-rich box 1) and CEBPα (CCAAT/enhancer binding protein α), monocytes, macrophages, and dendritic cells are the most vitamin D-sensitive immune cell types.
The central role of the immune system in various aging-related diseases suggests that immunocompetence describes not only the ability of an individual to resist pathogens and parasites but also to contest non-communicative diseases and the process of aging itself.
In this review, we argue that the individual-specific responsiveness to vitamin D relates to a person’s immunocompetence via the epigenetic programming function of VDR and its ligand 1,25(OH)2D3 during hematopoiesis as well as in the periphery.
This may provide a mechanism explaining how vitamin D protects against major common diseases and, in parallel, promotes healthy aging.

Conclusion suggests daily Vitamin D3 = 40 IU/kg (3,200 IU for 80 kg adult)

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VitaminDWiki – Seniors contains:

431 items in Seniors

see also
Overview Seniors and Vitamin D
Muscles and Vitamin D - many studies 125+ items
Overview Fractures and Falls and Vitamin D

Falls and Fractures category listing has 258 items along with related searches

Overview Alzheimer's-Cognition and Vitamin D
Overview Cancer and vitamin D
Overview Influenza and vitamin D

Cancer - Prostate category listing has 103 items along with related searches

Overview Diabetes and vitamin D
Hearing Loss appears to be prevented and treated with vitamin D

Mortality category listing has 320 items along with related searches

Overview Osteoporosis and vitamin D
Restless Legs Syndrome dramatically reduced by vitamin D, etc
Overview Rheumatoid Arthritis and vitamin D
Frailty and Vitamin D - many studies many studies
Nursing homes and Vitamin D - many studies
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has:

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
  14. Glutathione (which increases Vitamin D getting to cells) decreases with age
       Seniors category has 431 items

VitaminDWiki - 8 studies in both categories Seniors and Immunity

This list is automatically updated

Might be able to “square the curve” with Vitamin D (live both longer AND Healthier)

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7 of the many studies by Carlberg in VitaminDWiki

Items found: 5


Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019

Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016
   Daily dose of 3,200 IU
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Vitamin D - A master example of nutrigenomics – April 2023
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38+ VitaminDWiki pages have AGING in the title

This list is automatically updated

Items found: 39
Title Modified
Life extension by physical activity or more than 34 ng of Vitamin D – together they reduce aging by 1.3 years – July 2024 13 Jun, 2024
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Vitamin D and Aging: Central Role of Immunocompetence – Carlberg Jan 2024 21 Mar, 2024
The Science of Magnesium and Its Role in Aging and Disease - Patrick March 2024 20 Mar, 2024
Vitamin K can reduce aging - April 2021 25 Dec, 2023
Vitamin D reduces aging and prevents disease (less oxidative stress) - Dec 2022 07 Dec, 2022
Aging of the Immune system (Immunosenescence): micronutrients and gut microbiota – Oct 2022 03 Oct, 2022
Age of menopause increases if add vitamin D or UVB 25 Aug, 2021
Several advanced-maternal-age problems reduced if given Vitamin D during pregnancy (mice in this case) – July 2021 11 Aug, 2021
Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017 17 May, 2021
Poorer sleep as Vitamin D levels drop with age – March 2021 20 Feb, 2021
Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020 07 Oct, 2020
Boys who were born Small for Gestational age are 1.9X more likely to be infertile – Dec 2019 20 Dec, 2019
Preterm birth increases risk of heart disease by 1.5 X by age 40 – June 2019 06 Aug, 2019
Low Vitamin D is one of the causes of oxidative stress and aging – March 2019 15 May, 2019
Medicaid pays for 70 percent of US pregnancies for women under age 25 – April 2019 25 Apr, 2019
Far healthier and stronger at age 72 due to supplements 27 Jan, 2019
Off Topic: Premature birth results in less schooling and income (age 28, 228,000 Danes) – Dec 2018 15 Dec, 2018
Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015 27 Jun, 2018
Half as many Small for Gestational Age infants when take 600 IU of vitamin D while pregnant – June 2018 27 Jun, 2018
Vitamin D reduced so low that Victorian age diseases are returning 05 Apr, 2018
Vitamin D gene expression varies with Epileptic age – March 2018 20 Mar, 2018
Prematurely aging kids (Hutchinson-Gilford Progeria Syndrome) might be helped by Vitamin D– March 2018 20 Mar, 2018
Hypothesis – less vitamin D results in faster aging – Nov 2017 17 Nov, 2017
The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018 21 Oct, 2017
Genes which regulate active vitamin D worsen with age – Oct 2016 31 Oct, 2016
Small for gestational age with low vitamin D – 3.6X higher for blacks than whites – April 2016 21 Apr, 2016
Anti-aging Effect of Magnesium on Telomeres (in rats) - Mar 2014 15 Apr, 2016
Obese of all ages have lower levels of vitamin D – meta-analysis May 2015 10 May, 2015
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
Understanding vitamin D deficiency - Editorial in Age and Ageing July 2014 02 Aug, 2014
Vitamin D deficiency in Rheumatology clinics in Iran (D increases with age)– May 2013 02 Nov, 2013
Huge variation in taking vitamin D supplements with age of female, less than 1000 IU not help much – July 2013 29 Aug, 2013
Unspecified differences in vitamin D at age 10 failed to predict intelligence at age 15 – April 2012 13 Apr, 2012
Appears that some CNS ageing problems can be avoided with vitamin D – July 2010 06 Oct, 2011
Forum on Aging and Skeletal Health – Sept 2011 17 Sep, 2011
Kidney aging-inevitable or preventable – Aug 2011 25 Aug, 2011
Amylase increases with age, as does weight 10 Aug, 2010
How much calcidiol or calcitriol is needed to slow aging in mice – 2009 02 Jul, 2010


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