Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel – Dec 2011

Nutrients 2012, 4(1), 13-28; doi:10.3390/nu4010013
Review
Anderson P. Jones, Meri K. Tulic, Kristina Rueter and Susan L. Prescott sprescott@meddent.uwa.edu.au
School of Paediatrics and Child health, University of Western Australia, Perth, Western Australia 6008, Australia
Received: 11 November 2011; in revised form: 2 December 2011 / Accepted: 20 December 2011 / Published: 28 December 2011
(This article belongs to the Special Issue Nutritional Immunology)
Download PDF Full-Text 198 KB, uploaded 28 December 2011 13:45 CET

Abstract: A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1?,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases.

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