- The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis
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5 studies in both categories Pregnancy and Osteoporosis 13 Osteoporosis Vitamin D Receptor studies - VitaminDWiki - Bone Mineral Density and Vitamin D - many studies 29+
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis
Osteoporos Int. 2023 Apr 27. doi: 10.1007/s00198-023-06751-5 PDF is behind payeall
Rebecca J Moon 1 2, Harry D Green 3, Stefania D'Angelo 3, Keith M Godfrey 3 4, Justin H Davies 5 6, Elizabeth M Curtis 3, Cyrus Cooper 3 4 7, Nicholas C Harvey 3 4Systematic review and meta-analysis of the effect of moderate- to high-dose vitamin D supplementation in pregnancy on offspring bone mineralisation found a positive effect of vitamin D supplementation on offspring bone mineral density (BMD) at age 4-6 years, with a smaller effect on bone mineral content.
Purpose: A systematic review and meta-analysis was performed to assess the effect of pregnancy vitamin D supplementation on offspring bone mineral density (BMD) in childhood.
Methods: A literature search was conducted for published RCTs of antenatal vitamin D supplementation with assessment of offspring BMD or bone mineral content (BMC) by dual-energy X-ray absorptiometry (DXA) using MEDLINE and EMBASE up to 13th July 2022. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Study findings were grouped in two age groups of offspring assessment: neonatal period and early childhood (3-6 years). Random-effects meta-analysis of the effect on BMC/BMD at 3-6 years was performed using RevMan 5.4.1, yielding standardised mean difference (SMD) (95% CI).
Results: Five RCTs were identified with offspring assessment of BMD or BMC; 3250 women were randomised within these studies. Risk of bias was low in 2 studies and "of concern" in 3. Supplementation regimes and the control used (3 studies used placebo and 2 used 400 IU/day cholecalciferol) varied, but in all studies the intervention increased maternal 25-hydroxvitamin D status compared to the control group. Two trials assessing BMD in the neonatal period (total n = 690) found no difference between groups, but meta-analysis was not performed as one trial represented 96.4% of those studied at this age. Three trials assessed offspring whole-body-less-head BMD at age 4-6 years. BMD was higher in children born to mothers supplemented with vitamin D [0.16 SD (95% confidence interval 0.05, 0.27), n = 1358] with a smaller effect on BMC [0.07 SD (95% CI - 0.04, 0.19), n = 1351].
Conclusions: There are few RCTs published to address this question, and these are inconsistent in methodology and findings. However, meta-analysis of three trials suggests moderate- to high-dose vitamin D supplementation in pregnancy might increase offspring BMD in early childhood, but further trials are required to confirm this finding. (Prospero CRD42021288682; no funding received).
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5 studies in both categories Pregnancy and Osteoporosis This list is automatically updated
- Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023
- More UV during first trimester, less Osteoporosis in offspring – June 2019
- Vitamin D, Calcium and protein very important to bone health – Sept 2015
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- Calcium and bone disorders in pregnancy – May 2012
13 Osteoporosis Vitamin D Receptor studies - Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018
- Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
VitaminDWiki - Bone Mineral Density and Vitamin D - many studies 29+
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