Possible Roles of Vitamin D in Bone Grafting
Cureus. 2021 Apr 26;13(4):e14688. doi: 10.7759/cureus.14688.
Georgios Markopoulos 1, Panagiotis Lepetsos 2, Despina N Perrea 3, Dimitrios C Iliopoulos 3, Vasileios S Nikolaou 1
Anticipate to be succesful that they will need to
1) Raise Vitamin D levels BEFORE bone grafting
2) Provide topical vitamin D directly to the graft
3) Provide cofactors needed to build bone (Magnesium, Boron, etc)
Bone - Health category starts with the following
See also
- Overviews: Osteoporosis, Fractures, Rickets Dental Hair
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16 articles are in both Bone and Magnesium categories 29 articles are in both Bone and Vitamin K2 categories 18 articles are in both Bone and Sports categories 8 articles are in both Bone and Meta-analysis categories 25 articles are in both Fractures and Meta-analysis categories - Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- VitaminDWiki pages with BONE MINERAL DENSITY or BMD in title 25 pages as of Feb 2023
- Hearing loss is associated with soft bones in ear
- Perhaps prevented and treated by Vitamin D
- See also Overview of Rickets and Vitamin D Overview Osteoporosis and vitamin D
Download the PDF from VitaminDWiki
Bone grafting is one of the most commonly used options to treat large bone defects. Evidence has shown that vitamin D may affect osseointegration, a major component for successful bone grafting. In vitro studies have proved that implants coated with activated vitamin D stimulate bone production and reduce bone resorption around implants. Animal studies have noticed that oral administration of vitamin D may stimulate bone formation as well as strengthen and support the interaction between bone and implants. Vitamin D insufficiency may affect negatively the cortical peri-implant bone formation, suggesting a negative effect in graft incorporation. Few clinical studies have observed that vitamin D administration enhanced graft incorporation and bone formation, while severe vitamin D deficiency is associated with failed implant osseointegration. Even though there are encouraging results of vitamin D supplementation on graft incorporation in animal studies, the use of vitamin D as an adjuvant in bone grafting procedures cannot be fully supported at the moment. However, there is theoretical support in the use of vitamin D after surgery and the use of bone grafts to support the bone structure, relieve pain and increase graft absorption. Further experimental and clinical studies are required to support the administration of vitamin D and its analogues in such cases.
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