Vitamin D metabolism and genes as of Nov 2019

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Vitamin D Metabolism Revised: Fall of Dogmas

JBMR https://doi.org/10.1002/jbmr.3884
Roger Bouillon,Dan Bikle

PDF table on Contents

Summary and Perspective
The dual origin of vitamin D, discovered about a century ago, first evolved into a rather simple metabolic schema of constitutive 25-hydroxylation of vitamin D in the liver to produce 25OHD, followed by a tightly regulated 1α-hydroxylation by a unique CYP27B1 in a unique organ (kidney) to generate 1,25(OH)2D as ligand of a nuclear receptor, VDR. All these metabolites are transported by a single serum binding protein and are finally catabolized by a unique nearly ubiquitous CYP24A1. The present picture is much more complex with a large number of enzymes expressed in a variety of cells. Most of these genes contain genetic polymorphisms that may alter their function and are regulated by hormones and/or metabolic signaling that can vary in different tissues of the body. Finally, the vitamin D endocrine system regulates a large number of vertebrate genes. These recent findings reveal that the vitamin D endocrine system is much more complex than initially thought and remains still incompletely understood.
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VitaminDWiki - Genetics category contains

344 articles in the Genetics category

see also

• Vitamin D Receptor has 534 items
• Vitamin D Binding Protein = GC has 178 items
• CYP27B1 has 63 items
• CYP24A1 in title of 39+ items
• CYP2R1 25+ items
• Calcidiol has 49 items
• Calcitriol has 63 items
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
• CYP3A4 (7 as of Dec 2022)
• Getting Vitamin D into your blood and cells
• 

Vitamin D blood test misses a lot