COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021


The relevance of magnesium homeostasis in COVID-19

European Journal of Nutrition volume 61, pages 625–636 (2022)
Valentina Trapani, Andrea Rosanoff, Shadi Baniasadi, Mario Barbagallo, Sara Castiglioni, Fernando Guerrero-Romero, Stefano Iotti, André Mazur, Oliver Micke, Guitti Pourdowlat, Giuliana Scarpati, Federica I. Wolf & Jeanette A. Maier

How Magnesium might fight COVID

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Completed trials

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On-going trials (June 2021?)

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Magnesium might help with Long-Haul

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Purpose
In less than one and a half year, the COVID-19 pandemic has nearly brought to a collapse our health care and economic systems. The scientific research community has concentrated all possible efforts to understand the pathogenesis of this complex disease, and several groups have recently emphasized recommendations for nutritional support in COVID-19 patients. In this scoping review, we aim at encouraging a deeper appreciation of magnesium in clinical nutrition, in view of the vital role of magnesium and the numerous links between the pathophysiology of SARS-CoV-2 infection and magnesium-dependent functions.

Methods
By searching PubMed and Google Scholar from 1990 to date, we review existing evidence from experimental and clinical studies on the role of magnesium in chronic non-communicable diseases and infectious diseases, and we focus on recent reports of alterations of magnesium homeostasis in COVID-19 patients and their association with disease outcomes. Importantly, we conduct a census on ongoing clinical trials specifically dedicated to disclosing the role of magnesium in COVID-19.

Results
Despite many methodological limitations, existing data seem to corroborate an association between deranged magnesium homeostasis and COVID-19, and call for further and better studies to explore the prophylactic or therapeutic potential of magnesium supplementation.

Conclusion
We propose to reconsider the relevance of magnesium, frequently overlooked in clinical practice. Therefore, magnesemia should be monitored and, in case of imbalanced magnesium homeostasis, an appropriate nutritional regimen or supplementation might contribute to protect against SARS-CoV-2 infection, reduce severity of COVID-19 symptoms and facilitate the recovery after the acute phase.

 Download the PDF from VitaminDWiki


Study was cited 7 times as of June 2022

Google Scholar

  • Magnesium-to-Calcium Ratio and Mortality from COVID-19 - April 2022 PDF
  • Populations in Low-Magnesium Areas Were Associated with Higher Risk of Infection in COVID-19’s Early Transmission: A Nationwide Retrospective Cohort Study in the United States - PDF
  • Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection - March 2022 PDF
  • Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study - May 2022 PDF

See also Long Covid, Short Magnesium - Chambers April 2022


VitaminDWiki - 26 studies in both categories Virus and Magnesium

This list is automatically updated


VitaminDWiki pages with LONG-HAUL or LONG-COVID in title (40: July 2022)

Items found: 73
Title Modified
COVID Long-Haul at 49 weeks: overactive immune system, type O blood - March 2022 07 Apr, 2022
Children have less severe COVID, but just as much long-haul as adults - April 2022 06 Apr, 2022
Dietary Recommendations for COVID Long-Haul – March 2022 20 Mar, 2022
Mild Long-Haul 4.2 X more likely if type O blood - preprint March 16, 2022 20 Mar, 2022
Long-Haul COVID is somewhat less of a problem if vaccinated – Nov 2021 18 Mar, 2022
COVID long-haul: 1 million in US too sick to work, many cannot get compensation - March 2021 09 Mar, 2022
COVID Long-Haul NYT - Feb 2022 19 Feb, 2022
COVID Long-Haul fought by probiotics - Jan 2022 29 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
Some COVID-19 infection become COVID Long-Haul - Nov 2020 15 Dec, 2021
Long-haul after breakthrough COVID – Nov 2021 11 Dec, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 07 Aug, 2021
Long-haul COVID-19 blood tests at Mayo include vitamin D (but no results published) – July 2021 20 Jul, 2021
Most people with Long-Haul COVID-19 have low Vitamin D – July 2021 15 Jul, 2021
‘Long haul’ COVID rehab worse than cancer rehab, CDC – July 2021 13 Jul, 2021
Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021 15 Jun, 2021
COVID-19 Long haul - excellent graph - systematic review May 26, 2021 26 May, 2021
COVID-19 vaccines look good in the short term, but probably not good for the long term 29 Apr, 2021
Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020 16 Apr, 2021
Probably fewer long-haul COVID-19 problems when rejuvenated immune system (Vitamin D, etc.)– Dec 2020 21 Feb, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
Long-distance truck drivers more likely to get COVID-19 (perhaps UVA)- July 2020 12 Aug, 2020
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