COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021

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The relevance of magnesium homeostasis in COVID-19

European Journal of Nutrition volume 61, pages 625–636 (2022)
Valentina Trapani, Andrea Rosanoff, Shadi Baniasadi, Mario Barbagallo, Sara Castiglioni, Fernando Guerrero-Romero, Stefano Iotti, André Mazur, Oliver Micke, Guitti Pourdowlat, Giuliana Scarpati, Federica I. Wolf & Jeanette A. Maier

How Magnesium might fight COVID

Completed trials

On-going trials (June 2021?)

Magnesium might help with Long-Haul

Purpose
In less than one and a half year, the COVID-19 pandemic has nearly brought to a collapse our health care and economic systems. The scientific research community has concentrated all possible efforts to understand the pathogenesis of this complex disease, and several groups have recently emphasized recommendations for nutritional support in COVID-19 patients. In this scoping review, we aim at encouraging a deeper appreciation of magnesium in clinical nutrition, in view of the vital role of magnesium and the numerous links between the pathophysiology of SARS-CoV-2 infection and magnesium-dependent functions.

Methods
By searching PubMed and Google Scholar from 1990 to date, we review existing evidence from experimental and clinical studies on the role of magnesium in chronic non-communicable diseases and infectious diseases, and we focus on recent reports of alterations of magnesium homeostasis in COVID-19 patients and their association with disease outcomes. Importantly, we conduct a census on ongoing clinical trials specifically dedicated to disclosing the role of magnesium in COVID-19.

Results
Despite many methodological limitations, existing data seem to corroborate an association between deranged magnesium homeostasis and COVID-19, and call for further and better studies to explore the prophylactic or therapeutic potential of magnesium supplementation.

Conclusion
We propose to reconsider the relevance of magnesium, frequently overlooked in clinical practice. Therefore, magnesemia should be monitored and, in case of imbalanced magnesium homeostasis, an appropriate nutritional regimen or supplementation might contribute to protect against SARS-CoV-2 infection, reduce severity of COVID-19 symptoms and facilitate the recovery after the acute phase.

 Download the PDF from VitaminDWiki

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Study was cited 7 times as of June 2022

Google Scholar

• Magnesium-to-Calcium Ratio and Mortality from COVID-19 - April 2022 PDF
• Populations in Low-Magnesium Areas Were Associated with Higher Risk of Infection in COVID-19’s Early Transmission: A Nationwide Retrospective Cohort Study in the United States - PDF
• Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection - March 2022 PDF
• Higher Intake of Dietary Magnesium Is Inversely Associated With COVID-19 Severity and Symptoms in Hospitalized Patients: A Cross-Sectional Study - May 2022 PDF

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See also Long Covid, Short Magnesium - Chambers April 2022

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VitaminDWiki - 26 studies in both categories Virus and Magnesium

This list is automatically updated

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VitaminDWiki pages with LONG-HAUL or LONG-COVID in title (40: July 2022)