Exploring Associations Between Vitamin D Status and Anemia in Pregnant Adolescents
The FASEB Journal, vol. 29 no. 1 Supplement 590.5
Carrie Thomas1, Ronnie Guillet2, Elizabeth Cooper2, Eva Pressman2, Mark Roberson3 and Kimberly O'Brien1
1Division of Nutritional Sciences Cornell University Ithaca NY United States
2School of Medicine and Dentistry University of Rochester Rochester NY United States
3Department of Biomedical Sciences Cornell University Ithaca NY United States
Vitamin D and iron (Fe) insufficiency are frequently shown to co-exist. However, interrelationships that may occur between these two nutrients have not been explored during pregnancy. The purpose of this study was to examine associations between Fe and vitamin D status in pregnant adolescents (n = 158, aged 蠄 18 y), a group known to be at risk for suboptimal vitamin D and Fe status. At mid-gestation (26.0 ± 3.3 weeks of gestation), maternal 25(OH)D was significantly and positively associated with maternal hemoglobin (Hb) (R2 = 0.065, p = 0.005, n = 118), and inversely associated with maternal erythropoietin (EPO) (R2 = 0.028, p = 0.04, n = 144). Significant relationships between 25(OH)D and both Hb and EPO remained evident at delivery. A trend towards greater hepcidin at mid-gestation was observed among adolescents with 25(OH)D levels < 12 ng/mL compared to those with 25(OH)D levels 蠅 12 ng/mL (mean hepcidin 31.8 ng/mL and 28.0 ng/mL, respectively; p = 0.07). Teens with 25(OH)D < 20 ng/mL were significantly more likely to be anemic at delivery compared to those with 25(OH)D 蠅 20 ng/mL (OR 7.61, p = 0.004).
Of note, all teens with iron deficiency anemia at delivery were also vitamin D insufficient (< 20 ng/mL) (Fisher's exact test 2-tail p = 0.01). These findings are supportive of an interrelationship between vitamin D and Fe insufficiency and emphasize the need for additional studies investigating the mechanisms responsible for these findings.
Funded by NIH Grant No. T32HD052471 and USDA Grant Nos. 2005-35200 and 2008-01857.
Later publication by many of the same authors - 8X
Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy.
Am J Clin Nutr. 2015 Oct 7. pii: ajcn116756.
Thomas CE1, Guillet R2, Queenan RA2, Cooper EM2, Kent TR1, Pressman EK2, Vermeylen FM3, Roberson MS4, O'Brien KO5.
1Division of Nutritional Sciences.
2University of Rochester School of Medicine and Dentistry, Rochester, NY.
3Cornell University Statistical Consulting Unit, and.
4Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY; and.
5Division of Nutritional Sciences, koo4@cornell.edu.
- "After adjustment for age at enrollment and race, the odds of anemia at delivery was 8 times greater in adolescents with delivery 25(OH)D concentrations <50 nmol/L than in those with 25(OH)D concentrations ≥50 nmol/L (P <0.001)"
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See also VitaminDWiki
- Deficiencies of iron and vitamin D are interrelated in women – March 2013
- 5X more likely to be vitamin D deficient if anemic - Dec 2012
- Overview Iron Supplements and Vitamin D
- Iron deficiency is a cause of Vitamin D deficiency also reviews other forms of Iron
- Iron and Vitamin D deficiencies are synergistic - April 2015