Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021

Etiology of Anemia in Older Mexican Adults: The Role of Hepcidin, Vitamin A and Vitamin D

Nutrients. 2021 Oct 27;13(11):3814. doi: 10.3390/nu13113814.
Vanessa De la Cruz-Góngora 1, Aarón Salinas-Rodríguez 1, Mario Flores-Aldana 2, Salvador Villalpando 2

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Anemia in older adults is a growing public health issue in Mexico; however, its etiology remains largely unknown. Vitamin A deficiency (VAD) and vitamin D deficiency (VDD) have been implicated in the development of anemia, though by different mechanisms. The aim of this study is to analyze the etiology of anemia and anemia-related factors in older Mexican adults. This is a cross-sectional study of 803 older adults from the southern region of Mexico in 2015. The anemia etiologies analyzed were chronic kidney disease (CKD), nutritional deficiencies (ND), anemia of inflammation (AI), anemia of multiple causes (AMC) and unexplained anemia (UEA). VAD was considered to be s-retinol ≤ 20 μg/dL, and VDD if 25(OH)D < 50 nmol/L. IL-6 and hepcidin were also measured. Multinomial regression models were generated and adjusted for confounders. Anemia was present in 35.7% of OA, independent of sex. UEA, CKD, AI and ND were confirmed in 45%, 29.3%, 14.6% and 7% of older adults with anemia, respectively. Hepcidin and log IL-6 were associated with AI (p < 0.05) and CKD (p < 0.001). VAD was associated with AI (p < 0.001), and VDD with ND and AMC (p < 0.05). Log-IL6 was associated with UEA (p < 0.001). In conclusion, anemia in older adults has an inflammatory component. VAD was associated to AI and VDD with ND and AMC.
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VitaminDWiki - Overview Iron Supplements and Vitamin D has the following table by Mercola


Diseases associated with

Low iron (menstruating) High iron (males)
Anemia Anemia of chronic disease
Fibromyalgia Premature aging
Inflammatory bowel disease Atherosclerosis
Hypothyroidism Anorexia
Depression / anxiety Grave's disease
Attention deficit hyperactivity disorder Heart arrhythmia
Parkinson's disease Cancer
Neurodegenerative conditions Sideroblastic anemia
Celiac disease Nonalcoholic fatty liver disease (NAFLD).
Excess dietary fructose is a primary initiator of NAFLD,
but high iron is another culprit that triggers disease progression
Restless leg syndrome Liver damage and liver disease
Hair loss Still's disease
Muscle weakness, decline in motor skills Hemochromatosis
Mental changes and memory loss Hemophagocytic syndrome

Vitamin D pages containing "anemia" in title (15 as of Sept 2021)

Items found: 18
Title Modified
Anemia 8X more likely in infants if low vitamin D – Sept 2023 07 Sep, 2023
Anemia 1.6 X more likely during pregnancy if low Vitamin D – meta-analysis Dec 2021 02 Jan, 2022
Anemia in pregnant teens 7X more likely if low vitamin D – April 2015 28 Nov, 2021
Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021 28 Nov, 2021
Anemia in children 3.5 X more likely if low vitamin D – March 2018 21 Nov, 2018
Anemia (in heart failure) not treated by Vitamin D (they should have added Iron) – RCT Aug 2017 25 Aug, 2017
Sickle Cell Anemia: 64 percent had less than 10ng of vitamin D – April 2012 06 Mar, 2017
Those with Ulcerative colitis and low vitamin D were 3.3X more likely to have anemia – Oct 2013 18 Jan, 2017
Hypothesis: Iron deficiency anemia results in reduced vitamin D in blood 19 Jun, 2016
Low vitamin D - anemia 2.2X more likely (no surprise) – meta-analysis Aug 2015 28 Aug, 2015
Anemia perhaps results in low vitamin D for premenosausal women – March 2013 28 Aug, 2015
Inflammation Anemia in Blacks 8X more likely if less than 20 ng of vitamin D – April 2015 22 Aug, 2015
Anemia 1.9X more likely in white children having lowish vitamin D – Jan 2014 10 Aug, 2015
2X increased chance of anemia (low iron) associated with low vitamin D – Sept 2013 17 Apr, 2015
Infants who have iron deficiency anemia are 4X more likely to be vitamin D deficient – March 2013 15 Dec, 2014
Anemia associated with lower than 20 ng vitamin D among elderly – Jan 2011 15 Dec, 2014
Having celiac disease and low vitamin D only predicted psoriasis and anemia – Jan 2013 10 Jul, 2014
Another indiction that lower level of vitamin D are OK in blacks – Anemia Oct 2013 13 Oct, 2013

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