Crohn's and Vitamin D - many studies

38+ VitaminDWiki pages with CROHN'S in title

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Crohn's and Vitamin D - many studies 29 Dec, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015 26 Mar, 2021
Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 26 Mar, 2021
Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013 09 Feb, 2021
Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021 09 Feb, 2021
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019 28 Sep, 2019
Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 07 May, 2019
Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 28 Aug, 2018
Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018 15 May, 2018
Crohn's patients with Vitamin D less than 30 ng were 1.8 X more likely to be readmitted within 1 year – April 2017 13 Mar, 2018
Crohn's disease in black children is worse in 6 ways – Dec 2015 10 Dec, 2017
Crohn's Disease flares 20 percent more likely if poor Vitamin D Binding Protein – Oct 2016 09 Nov, 2017
Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017 12 Oct, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,0000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 16 Jul, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 15 Jul, 2017
Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015 31 Jan, 2017
Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 11 Dec, 2016
Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 14 Nov, 2016
Crohn’s disease associated with low vitamin D, unless in remission (22 vs 28ng)– Dec 2015 30 Jul, 2016
Is vitamin D supplementation a viable treatment for Crohn's disease – Nov 2015 18 Nov, 2015
Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D – Sept 2015 12 Sep, 2015
Crohn's disease treated by Vitamin D - RCT June 2015 07 Aug, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Crohn’s helped by 5000 IU vitamin D – April 2013 17 Feb, 2015
Crohn’s Disease – strange things such as no change of vitamin D levels with season – Dec 2014 09 Dec, 2014
Surgery for Crohn's disease 2X less likely if managed to raise vitamin D above 30 ng – May 2013 06 May, 2014
Active Crohn's disease is associated with low vitamin D levels – Feb 2013 14 Feb, 2013
About 40 percent more likely to get Crohn’s Disease or UC if have low vitamin D – March 2012 03 Nov, 2012
More than half those with Crohn’s disease have less than 20ng of vitamin D – March 2012 03 Nov, 2012
Even 800 IU vitamin D improved Crohn’s disease bone density – June 2012 03 Jul, 2012
Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps – April 2012 12 Jun, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Crohn’s Disease strongly associated with low vitamin D in South Asians – March 2012 29 Mar, 2012
Extra Vitamin D needed for Crohns 14 Mar, 2012
Crohn’s relapse reduced from 29% to 13% by taking 1200 IU of D3 – May 2010 04 Apr, 2011

Vitamins D and B12 are the most frequently reported deficiences with Crohn's Disease - Nov 2023

Micronutrient Status in Adult Crohn's Disease during Clinical Remission: A Systematic Review
Nutrients. 2023 Nov 14;15(22):4777. doi: 10.3390/nu15224777.
Martin McDonnell 1 2, Stephanie Sartain 1 2, Catherine Westoby 1 2 3, Vasiliki Katarachia 1 2 3, Stephen A Wootton 1 2, J R Fraser Cummings 2 4

Adults with Crohn's disease (CD) may be at risk of micronutrient insufficiency in clinical remission through restrictive eating, malabsorption, abnormal losses or inflammation. This systematic review synthesises the literature on micronutrient insufficiency in CD in clinical remission in terms of the prevalence of low circulating micronutrient concentrations and as a comparison against a healthy control (HC). Studies were included if the population was predominantly in remission. A total of 42 studies met the inclusion criteria; 12 were rated as low quality, leaving 30 studies covering 21 micronutrients of medium/high quality that were included in the synthesis.
Vitamins D and B12 were the most frequently reported nutrients (8 and 11); there were few eligible studies for the remaining micronutrients.
The prevalence studies were consistent in reporting individuals with low

  • Vitamins
    • A,
    • B6,
    • B12
    • C,
    • β-carotene,
    • D,
  • Magnesium,
  • Selenium and
  • Zinc.

The comparator studies were inconsistent in finding differences with CD populations;
Vitamin D, the most reported nutrient, was only lower than the HC in one-quarter of the studies.
Adult CD populations are likely to contain individuals with low levels of one or more micronutrients, with the most substantial evidence for Vitamins D and B12. The studies on other micronutrients are of insufficient number, standardisation and quality to inform practice.
 Download the PDF from VitaminDWiki

Half as many Crohn's relapses if regularly take Vitamin D - Dec 2022

Effectiveness of Vitamin D Supplementation on Disease Course in Inflammatory Bowel Disease Patients: Systematic Review With Meta-Analysis
Inflamm Bowel Dis . 2022 Dec 29;izac253. doi: 10.1093/ibd/izac253
Marco Valvano 1, Marco Magistroni 1, Nicola Cesaro 1, Giorgio Carlino 1, Sabrina Monaco 1, Stefano Fabiani 1, Antonio Vinci 2, Filippo Vernia 1, Angelo Viscido 1, Giovanni Latella 1

Background: The vitamin D role in bone metabolism is well known; however, recent evidence suggests the impact of vitamin D in immune modulation and its implications in immune-mediated diseases, including inflammatory bowel disease (IBD).

Method: We performed a systematic review with meta-analysis by a specific protocol (PROSPERO: CRD42022311184; March 2022, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=311184). Randomized clinical trials involving IBD patients treated with vitamin D supplementation, compared with placebo, that evaluated the risk of clinical relapse and disease activity were included. Literature search was performed using Medline, Scopus, and Cochrane CENTRAL through January 2022.

Results: Out of 1448 articles, 12 (11 full-texts and 1 abstract) were included. Seven randomized clinical trials reported data on the clinical relapse as dichotomous outcome, while 7 studies reported data on disease activity expressed as continuous variables. The pooled risk ratio of clinical relapse was 0.64 (95% confidence interval, 0.46-0.89; I2 = 25%) among 458 IBD patients. However, this seems to be solid only in Crohn's disease (CD) patients. In fact, only 2 studies, involving 67 patients with ulcerative colitis, were included in the analysis. CD patients in clinical remission had a strong significant risk reduction in clinical relapse (risk ratio, 0.47; 95% confidence interval, 0.27-0.82; I2 = 0%), suggesting that it could be a specific subgroup with maximum clinical benefit of vitamin D supplementation.

Conclusions: This meta-analysis shows that vitamin D supplementation can reduce the risk of clinical relapse in IBD patients, especially in CD patients in clinical remission. In a subgroup analysis, it was not significant (due to small number of studies and low number of patients), and well-powered studies are needed, in particular for ulcerative colitis patients.

VitaminDWiki - Gut category listing contains

207 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 38 items along with related searches.

VitaminDWiki - Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
Image

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol		D - Slow
C -Fast		Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)		Slow
Fast nano		Normal
9Nanoemulsion -mucosal
perhaps activates VDR		FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)		FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

The risk of 47 diseases at least double with poor Vitamin D Receptor

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

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