Highly likely that neonate will be vitamin D deficient if the mother was - Sept 2024

Estimation of Vitamin D Levels in Neonatal Cord Blood Sample & its Correlation with Maternal Vitamin D Levels During Pregnancy

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Afr. J. Biomed. Res. Vol. 27, No.1s (September) 2024
Dr Wajid Rana 1, Dr Jabeena Banoo 2, Dr Sharvil Dhar 3, Dr Ariba Afeeh 4*, Dr Akhil
Preet Kau r5, Dr Aamil Haameem 6
1 department of Pediatrics, Acharya Shri Chander College of Medical Sciences & Hospital (india)
2 Gynaecology Senior Resident, Department of Obstetrics and Gynaecology, SMGS Hospital.
3’4*’5Department of Pediatrics, Acharya Shri Chander College of Medical Sciences & Hospital
6 Anesthesiology, Geisinger Medical Center Danville Pennsylvania USA

Background: high prevalence of Vitamin D deficiency has been observed in pregnant Indian women and their newborns, variation in the prevalence of Vitamin D during pregnancy has been observed from various parts of India which may be due to differences in the ethnicity, food habits, and geographical location. Maternal vitamin D deficiency has been shown to negatively impact the fetus, increasing the risks of intrauterine growth restriction, preeclampsia, gestational diabetes, and preterm birth. These conditions can significantly affect newborn health and development.

Aim & Objective: To find out the prevalence of vitamin D deficiency in newborns and Correlation of maternal and neonatal vitamin d levels.

Methods: The present study is a cross-sectional observational study conducted from July 2023 to September 2023 in the Perinatology section of Department of Pediatrics, at a tertiary care hospital of Jammu city. After selecting pregnant women of age 20 to 35 years with singleton term pregnancy, written informed consent was taken during antennal period and blood sample for vitamin D level was collected along with their routine lab investigations and was sent for estimating vitamin D levels. The samples of the new born were taken from cord blood and then were sent for vitamin D level. Results: There was a positive correlation between the Vitamin D levels of the mother and the neonates at birth. 97.1% of the newborns born to the mothers with deficient levels of vitamin D had deficient vitamin D levels (p-value 0.02)

Conclusion: Vitamin D deficiency is widely prevalent in our region with 81.3% neonates having VDD. Vitamin D deficiency in the mothers is also widely prevalent. Vitamin D deficiency is more prevalent among the early terms as compared to the full terms. Vitamin D deficiency is more prevalent in the small for gestational age infants as compared to the appropriate for gestational age infants.

Relevance: Since there is a paucity of data in our setup and also because of long term complication of vitamin D deficiencies in neonates we decided to perform a study to evaluate the levels of vitamin D in neonates and correlating the neonatal vitamin D levels with the maternal levels.
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16+ VitaminDWiki pages have NEONATE in the title

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Items found: 16
Title Modified
Highly likely that neonate will be vitamin D deficient if the mother was - Sept 2024 15 Sep, 2024
Chinese neonates 3.6 X more likely to have low vitamin D if previous month was cold – May 2024 25 May, 2024
Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023 16 Feb, 2023
Majority of South Asian children and youths have low vitamin D (85 pcnt of neonates) – March 2022 18 Mar, 2022
Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019 27 Jun, 2019
Vitamin D needed by pregnant women and neonates (in developing countries now too - 2 tables) – May 2018 19 May, 2018
Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018 22 Apr, 2018
Vitamin K guidelines for neonates need to be reconsidered – March 2018 20 Mar, 2018
Neonates were 288 gram (0.6 lbs) heavier if mother stopped smoking while pregnant – Oct 2016 21 Mar, 2017
Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014 29 Oct, 2016
Twice as many neonates got vitamin D after instructions to doctors were simplified. – Aug 2014 13 Sep, 2016
Neonates with sepsis had half the levels of vitamin D - 2015 30 Aug, 2016
Inflammation (CRP) 3X higher in Winter-Spring neonates with low vitamin D – Nov 2015 10 Nov, 2015
Neonate horses (as well as neonate humans) having low vitamin D are more likely to die. – June 2015 06 Jun, 2015
Effects of low vitamin D on pregnancy and neonate – review Jan 2015 16 Jan, 2015
Neonate Rickets was virtually always associated with very low maternal vitamin D – Dec 2014 18 Dec, 2014

Just 20 Vitamin D capsules taken during pregnancy would eliminate Vitamin D deficiency (cost = $ 5)

One pill every two weeks gives you all the vitamin D most adults need
50,000 IU of Vitamin D once every two weeks proven to prevent/treat:

Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + BPH (prostate) + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Growing Pain + Multiple Sclerosis + PMS + Schizophrenia + Endometriosis + Smoking    27 problems
   Note: Once a week also fights: COVID, Headaches, Colds, Fibromyalgia, Asthma, Hives, Colitis etc.

Infant/Child (843+)
     Allergy (36+)
     Cancer (13+)
     Cerebral Palsy (15+)
     Down Syndrome (5+)
     Fracture, low energy (10+)
     Growing Pains (10+)
     Pneumonia (25+)
     Preemie (25+)
     Puberty early if low D (9+)
     Respiratory (21+)
     RSV (25+)
     Tonsils (9+)
     Vaccination (10+)
     Virus (42+)

A few recent studies of low vitamin D in infants/Children

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