How Vitamin D helps the body fight viral infections such as COVID-19 – Sept 2024


Role of vitamin D in COVID-19 and other viral infections

World J Virol. Sep 25, 2024; 13(3):  doi: 10.5501/wjv.v13.i3.95349
Muhammet Mesut Nezir Engin,
Öner Özdemir onerozdemir@sakarya.edu.tr

Table of Contents
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Vitamin D is a steroid hormone that is naturally produced in the body or obtained through dietary sources, primarily under the influence of UVB radiation. This essential nutrient has a vital role in numerous physiological processes, encompassing immune function, cell growth, differentiation, insulin regulation, and cardiovascular well-being, along with its pivotal role in sustaining the delicate equilibrium of calcium and phosphate concentrations in the body.
Moreover, vitamin D reinforces mucosal defense and bolsters the immune system through immunomodulation, making it a critical component of overall health.
Numerous studies have unveiled the profound connection between vitamin D and the predisposition to respiratory tract infections, including well-known viruses such as influenza and the novel severe acute respiratory syndrome coronavirus 2.
Vitamin D deficiency has been consistently linked to increased severity of coronavirus disease 2019 (COVID-19) and a heightened risk of mortality among afflicted individuals.
Retrospective observational studies have further substantiated these findings, indicating that levels of vitamin D are linked with both the occurrence and severity of COVID-19 cases.
Vitamin D has its influence on viral infections through a multitude of mechanisms, such as promoting the release of antimicrobial peptides and fine-tuning the responses of the immune system.
Additionally, vitamin D is intertwined with the intricate network of the renin–angiotensin system, suggesting a potential impact on the development of complications related to COVID-19.
While further clinical trials and extensive research are warranted, the existing body of evidence strongly hints at the possible use of vitamin D as a valuable tool in the prophylaxis and management of COVID-19 and other viral infectious diseases.

Core Tip: While further clinical trials and extensive research are warranted, the existing body of evidence strongly hints at the possible use of vitamin D as a valuable tool in the prophylaxis and management of coronavirus disease 2019 and other viral infectious disease.

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Some COVID and Vitamin D studies

Some other Virus and Vitamin D studies


VitaminDWiki – 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D includes

CDC: Confirms Low Vitamin D
VitaminDWiki and other
Cancer VitaminDWiki 7X
Chronic kidney diseaseVitaminDWiki
COPD & other lung problemsPneumonia - VDW
Lung Death 4X
Down Syndrome VitaminDWiki - deficiency
Heart conditionsVitaminDWiki
Immunocompromised stateVitamin D helps organ transplant - many studies
Cancer - After diagnosis
Obesity Overview Obesity and Vitamin D
PregnancyOverview Pregnancy and vitamin D
Sickle cell diseaseOverview Sickle Cell and Vitamin D
Smoking Smoking reduces vitamin D - many studies
Diabetes T2VitaminDWiki
CDC: Might be factors
Asthma Overview Asthma and Vitamin D
Cerebrovascular disease Cardiovascular   Stroke
Cystic fibrosisCystic Fibrosis
Hypertension VitaminDWiki
ACE inhibitors VitaminDWiki 4X
Neurologic conditions,
such as dementia
Overview Alzheimer's-Cognition and Vitamin D
Liver diseaseOverview Liver and vitamin D
Pulmonary fibrosisPulmonary Fibrosis
Thalassemia VitaminDWiki - deficiency
Diabetes T1 T1 Diabetes
CDC: Still fails to mention
AgeOverview Seniors and Vitamin D
Nursing HomesNursing homes and Vitamin D - many studies
Prisons Prisoners have low Vitamin D - many studies
Dark SkinVitaminDWiki
Vertebral Fracture VitaminDWiki
Shift workVitaminDWiki 2X
Mood disorders Note:
Low D ==> depression
1.5X increase in COVID-19 death
Concealing clothingVitaminDWiki 3.5X
Schizophrenia 3X mortalityVitaminDWiki Low D since birth

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Sometimes A health problem will cause a Vitamin D deficiency
Sometimes A Vitamin D deficiency will cause another health problem
AlwaysStop a vitamin D deficiency to avoid getting additional health problems

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