Note: Most studies find poor VDR reduces Calcitriol getting the mitocondria, this study finds it reduces Calcidiol to blood
Table of contents
- Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis
- VitaminDWiki - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
- VDR can be activated
- VitaminDWiki - Resveratrol improves health (Vitamin D receptor, etc.) - many studies has:
- VitaminDWiki - Vitamin D Receptor category has:
- 55 health problems associated with poor VDR
- How to increase VDR activation
Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis
Nutrients 2022,14,360. https://doi.org/10.3390/ nu14020360
Ricardo Usategui-Martín 1,2,% Daniel-Antonio De Luis-Román3,4A José María Fernández-Gómez Marta Ruiz-Mambrilla 7 and José-Luis Pérez-
IOBA, University of Valladolid, 47011 Valladolid, Spain
Cooperative Health Network for Research (RETICS), Oftared, National Institute of Health Carlos III, ISCIII, 47011 Madrid, Spain
Department of Endocrinology, Clinical University Hospital, 47002 Valladolid, Spain; dluisro@saludcastillayleon.es
Department of Medicine, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain
Instituto de Endocrinología y Nutrición (IENVA), University of Valladolid, 47002 Valladolid, Spain
Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; josefg@med.uva.es
Department of Surgery, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; martamaria.ruiz@uva.es
Department of Internal Medicine, Río Hortega University Hospital, 47002 Valladolid, Spain
- Correspondence: ricardo.usategui@uva.es (R.U.-M.); joseluis.perez@uva.es (J.-L.P.-C.)
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001).
In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.
VitaminDWiki - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019__
VDR can be activated
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
VitaminDWiki - Resveratrol improves health (Vitamin D receptor, etc.) - many studies has:
- The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
- Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
- Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
- Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
- Quercetin and Curcumin in the case of Resveratrol
- Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Vitamin D Receptor
- Resveratol helps vitamin D bind to cells
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
VitaminDWiki - Vitamin D Receptor category has:
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
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