Table of contents
48 Resveratrol articles - See also VitaminDWiki
- Vitamin D Receptor category
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Genetics category
- Influence of Resveratrol on the Immune Response (Nothing about Vitamin D) - April 2019
- Resveratrol has a few problems for some people - Dr. Greger 4 video and transcript June 2024
- Resveratrol does not appear to extend life (many studies since 1991) - Dr. Greger June 2024
- Multiplicity of effects and health benefits of resveratrol – April 2015
- PubMed (3X increase in publications which include the word RESVERATROL in 13 years))
- Web
- Found My Fitness ( Dr. Patrick) on Reseveratrol
- Resveratrol overview at Examine.com July 2024
- RESVERATROL: REWRITING THE SCIENCE, Oct, 2018: by Bill Sardi
- Chart of Resveratrol benefits - Natural Biology
- Resveratrol, being a phytoestrogen, DECREASED Breast Cancer survival by 19% - Nov 2019
- Resveratrol oral and topical forms that are more bio-available
- Asked ChatGPT: What are the downsides to taking Resveratrol - Dec 2023
- Turmeric is as Effective as 14 Drugs (Turmeric also increases VDR activation) - March 2021
- Associations with: Vitamin D Receptor, Virus, Zinc, Omega-3, Vitamin C, Cognitive, Magnesium, Vitamin K, Curcumin, Boron
- There have been
28994 visits to this page
- The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
- Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
- Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
- Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
- Quercetin and Curcumin in the case of Resveratrol
18 articles in both of the categories Resveratrol and Vitamin D Receptor - Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Vitamin D Receptor
- Resveratol helps vitamin D bind to cells
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
48 Resveratrol articles - wiki page:
- Other forms of supplements are often more bio-available and faster acting - June 2024
- Supplements taken by the founder of VitaminDWiki
- Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Excellent reviews of supplements at ConsumerLab
- Nutritional supplementation during COVID hospitalization helped - RCT - Jan 2022
- COVID-19 appears reduced by Resveratrol plus 100K IU of vitamin D – Small RCT Sept 2021
- COVID-19 risk reduced 4X by each of: Vitamin D, Omega-3, Curcumin, Zinc (each increases D in cells)
- Many supplements appear to fight COVID-19 – vitamin D cited 52 times – May 2021
- COVID-19 Cytokine storms attenuated by Vitamin D, Omega-3, Mg, Resveratrol, etc – April 2021
- COVID-19 what it is, prevention by Functional Nutrition doctor - Feb 2021
- Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- COVID-19 possible therapies: Vitamin D, Selenium, Zinc, Vitamin C, Potassium, Resveratrol , etc.– Aug 5, 2020
- Fight COVID-19 with Vitamin D, Vitamin C, Zinc, Selenium, Resveratrol, etc. - Sardi May 12, 2020
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Longevity expert (Sinclair) supplements include Vitamin D, Vitamin K, and Resveratrol – Sept 2019
- Resveratrol benefits health in many ways - Dr. Patrick Sept 2019
- Treat wounds, stop inflammation with nanoemulsion textile of Omega-3 and Resveratrol - Sept 2019
- Resveratrol Efficacy improvements – special issue 2017
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
- Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- A comprehensive review of the health perspectives of resveratrol – Dec 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Resveratrol and inflammatory bowel disease: the evidence so far – June 2018
- Resveratrol and Brain Mitochondria: a Review – March 2018
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Beneficial action of resveratrol: How and why (BNDF, etc.)– Feb 2016
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Decrease of Alzheimer’s biomarker halted by Resveratrol (perhaps due to vitamin D) – RCT Sept 2015
- Vitamin D Receptor
- Vitamin D Cofactors in a nutshell
- Resveratol helps vitamin D bind to cells
- Immune system improvement by vitamin D is boosted by resveratrol and blueberries – Sept 2013
- Vitamin D and Resveratrol reduce weight gain in rats - Sept 2011
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
See also VitaminDWiki
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
- Bulk supplementation of Vitamin D, Magnesium, Zinc, B-12, K2, Boron etc. - lower cost and easier than pills
- Includes Resveratrol
- Note: Emulsions increase the bioavailability of Resveratrol (see below), Omega-3, and Vitamin D
Vitamin D Receptor category
530 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells48 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems19 studies), Breast Cancer ( 24 studies), Colon Cancer ( 13 studies), Cardiovascular ( 23 studies), Cognition ( 16 studies), Diabetes ( 24 studies), Hypertension ( 9 studies), Infant ( 22 studies), Lupus ( 6 studies), Metabolic Syndrome ( 4 studies), Mortality ( 4 studies), Multiple Sclerosis ( 14 studies), Obesity ( 17 studies), Pregnancy ( 24 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 37 studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14) Butyrate especially gut Vitamin D Receptor 15) Berberine Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Genetics category
343 articles in the Genetics category see also
- Vitamin D Receptor has
530 items - Vitamin D Binding Protein = GC has
178 items - CYP27B1 has
63 items - CYP24A1 in title of 39+ items
- CYP2R1 25+ items
- Calcidiol has
48 items - Calcitriol has
62 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 100 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
5) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc- The founder of VitaminDWiki took action with clues #3&5
Influence of Resveratrol on the Immune Response (Nothing about Vitamin D) - April 2019
Download the PDF from VitaminDWiki
Resveratrol has a few problems for some people - Dr. Greger 4 video and transcript June 2024
Side Effects of Resveratrol Supplements Dr. Greger
- Some studies have found that in increases LDL cholesterol by 25%
- " Daily doses of resveratrol in excess of a gram commonly cause mild to moderate gastrointestinal symptoms, such as nausea, diarrhea, and abdominal pain, as well as “anal itchiness.”
- "Two studies, however, found that so-called “safe” levels of resveratrol (at 150 to 250 mg a day) may blunt some of the positive effects of exercise training"
Sources
- Bashmakov YK, Assaad-Khalil SH, Abou Seif M, et al. Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients. ISRN Endocrinol. 2014;2014:816307.
- Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.
- Moxey PW, Gogalniceanu P, Hinchliffe RJ, et al. Lower extremity amputations- - a review of global variability in incidence. Diabet Med. 2011;28(10):1144-1153.
- Samsamikor M, Daryani NE, Asl PR, Hekmatdoost A. Resveratrol supplementation and oxidative/anti-oxidative status in patients with ulcerative colitis: a randomized, double-blind, placebo-controlled pilot study. Arch Med Res. 2016;47(4):304-309.
- Thaung Zaw JJ, Howe PRC, Wong RHX. Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial. Menopause. 2020;28(1):40-49.
- Monika null, Garg R, Sardana S. Research problems associated with resveratrol (Trans-3, 5, 4’- trihydroxystilbene; rsv) and various strategies to overcome those problems(Review). Curr Drug Deliv. 2017;14(3):364-376.
- Haghighatdoost F, Hariri M. Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials. Pharmacol Res. 2018;129:141-150.
- Kjær TN, Ornstrup MJ, Poulsen MM, et al. No beneficial effects of resveratrol on the metabolic syndrome: a randomized placebo-controlled clinical trial. J Clin Endocrinol Metab. 2017;102(5):1642-1651.
- Goh KP, Lee HY, Lau DP, Supaat W, Chan YH, Koh AFY. Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure. Int J Sport Nutr Exerc Metab. 2014;24(1):2-13.
- Cavallari I, Bhatt DL, Steg PG, et al. Causes and risk factors for death in diabetes: a competing-risk analysis from the savor-timi 53 trial. J Am Coll Cardiol. 2021;77(14):1837-1840.
- Tang PCT, Ng YF, Ho S, Gyda M, Chan SW. Resveratrol and cardiovascular health- - promising therapeutic or hopeless illusion? Pharmacol Res. 2014;90:88-115.
- Visioli F, Panaite SA, Tomé-Carneiro J. Wine’s phenolic compounds and health: a pythagorean view. Molecules. 2020;25(18):4105.
- Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL. Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci. 1996;59(1):PL15-21.
- Gliemann L. What are the chances that resveratrol will be the drug of tomorrow? Pharmacol Res. 2018;129:139-140.
- Semba RD, Ferrucci L, Bartali B, et al. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med. 2014;174(7):1077-1084.
- Wahab A, Gao K, Jia C, et al. Significance of resveratrol in clinical management of chronic diseases. Molecules. 2017;22(8):1329.
- Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K. Clinical trials of resveratrol. Ann N Y Acad Sci. 2011;1215:161-169.
- Shaito A, Posadino AM, Younes N, et al. Potential adverse effects of resveratrol: a literature review. Int J Mol Sci. 2020;21(6):2084.
- Popat R, Plesner T, Davies F, et al. A phase 2 study of SRT501 (Resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol. 2013;160(5):714-717.
- Gliemann L, Schmidt JF, Olesen J, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol. 2013;591(20):5047-5059.
- Scribbans TD, Ma JK, Edgett BA, et al. Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans. Appl Physiol Nutr Metab. 2014;39(11):1305-1313.
- Meng X, Zhou J, Zhao CN, Gan RY, Li HB. Health benefits and molecular mechanisms of resveratrol: a narrative review. Foods. 2020;9(3):340.
- Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021;40(3):820-829.
- Morris BJ. Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med. 2013;56:133-171.
- Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-622.
- Visioli F. The resveratrol fiasco. Pharmacol Res. 2014;90:87.
- Tang PCT, Ng YF, Ho S, Gyda M, Chan SW. Resveratrol and cardiovascular health - promising therapeutic or hopeless illusion? Pharmacol Res. 2014;90:88-115.
- Pezzuto JM. Resveratrol: twenty years of growth, development and controversy. Biomol Ther (Seoul). 2019;27(1):1-14.
- Gliemann L, Olesen J, Biensø RS, et al. Reply from Lasse Gliemann, Jesper Olesen, Rasmus Sjorup Bienso, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva Hellsten. J Physiol. 2014;592(3):553.
Resveratrol does not appear to extend life (many studies since 1991) - Dr. Greger June 2024
video and text summary with about 50 references
Multiplicity of effects and health benefits of resveratrol – April 2015
Medicina 2016, 52(3), 148-155; https://doi.org/10.1016/j.medici.2016.03.003
by Lolita Kuršvietienė 1,*,Inga Stanevičienė 1,2,Aušra Mongirdienė 1,3 andJurga Bernatonienė 4
1 Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2 Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
4 Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, LithuaniaResveratrol is mainly found in grapes and red wine, also in some plants and fruits, such as peanuts, cranberries, pistachios, blueberries and bilberries. Moreover, nowadays this compound is available as purified preparation and dietary supplement. Resveratrol provides a wide range of benefits, including
- cardiovascular protective,
- antiplatelet,
- antioxidant,
- antiinflammatory,
- blood glucose-lowering and
- anticancer activities,
hence it exhibits a complex mode of action. During the recent years, these properties have been widely studied in animal and human models, both in vitro and in vivo. This paper is intended to present information published during the recent years on the biological activities and multiple effects of resveratrol.
Download the PDF from VitaminDWiki
PubMed (3X increase in publications which include the word RESVERATROL in 13 years))
- Resveratrol: Twenty Years of Growth, Development and Controversy - Jan 2019
- Resveratrol potentiates vitamin D and nuclear receptor signaling - June 2015, doi: 10.1002/jcb.25070
- In VitaminDWiki as Resveratol helps vitamin D bind to cells
- Enhancing the Delivery of Resveratrol in Humans:If Low Bioavailability is the Problem, What is the Solution? - 2014
- Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis Sept 2018, doi: 10.1016/j.arr.2018.05.004
- Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. 2017 10.2174/1567205014666170207093455
- New strategies in sport nutrition to increase exercise performance Sept 2016 doi: 10.1016/j.freeradbiomed.2016.01.016 free PDF
- New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers Nov 2015 doi: 10.3332/ecancer.2015.601 free PDF
- Nutritional treatment for acute and chronic traumatic brain injury patients Sept 2014
- They found improvements by Reseveratrol, Omega-3, Magnesium, all of which improve the amount of Vitamin D getting to cells
- Resveratrol: A Double-Edged Sword in Health Benefits Sept 2018 10.3390/biomedicines6030091
- "Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects"
- Download the PDF from VitaminDWiki
- Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats Aug 2018 doi: 10.1016/j.jphs.2018.08.006
- Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles doi Sept 2018 10X increase in bio-availability
- Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol? Aug 2017 doi: 10.3390/ijms19092584 free PDF
- Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms| Aug 2018 10.3390/molecules23092197 free PDF
- Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study Aug 2018 10.1089/jmf.2017.4176
- Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation Aug 2018 doi: 10.3390/nu10091160 free PDF
- Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Sept 2017 doi: 10.1007/s00210-018-1566-5 Free PDF
- Resveratrol prevents atrial fibrillation by inhibiting atrial structural and metabolic remodeling in collagen-induced arthritis rats Aug 2018 doi: 10.1007/s00210-018-1554-9
- Pleiotropic mechanisms facilitated by resveratrol and its metabolites - July 2010
- Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review - March 2020
Web
summarized from: Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke
Download the PDF from VitaminDWiki- Resveratrol Linus Pauling Institute, Extensive, excellent, 2015
- Resveratrol in Food ResearchGate 2014
- Polygonum Cuspidatum = Japanese Knotweed
- Note: https://boingboing.net/2019/05/08/what-to-do-about-japanese-knot.htmlJapanese Knotweed has become a prolific weed in the US -May 2019
- 100 mg Resveratrol Improved Cadio measure even if given months after a stroke Sardi May 2018
- Resveratrol Shows Beneficial Effects in Ulcerative Colitis Dr. Murray / GreenMedinfo June 2019
Found My Fitness ( Dr. Patrick) on Reseveratrol
Resveratrol - 2019?
1Resveratrol's effects on human health and disease
1.1Metabolic and cardiovascular health and markers of inflammation
1.2Neurological health and Alzheimer’s disease
1.3Cancer
1.4Longevity
2 Physiological responses and molecular mechanisms associated with resveratrol intake
2.1Sirtuin activation
2.2Autophagy activation
2.3Resveratrol as an insect antifeedant and its role in xenohormesis
2.4Resveratrol as a calorie restriction mimetic
2.5Exercise performance enhancement from resveratrol
2.6Resveratrol supplementation and safety
3Conclusion
•Resveratrol news
Podcast Jan 2020 - for subscribers only
00:03:39 - Clinical effects of resveratrol in humans
00:04:10 - Effects on cardiovascular health biomarkers in humans
00:06:54 - Reduction of inflammatory biomarkers in humans
00:08:11 - Improved cognition and memory in clinical studies
00:11:23 - Healthspan improvements in animals
00:12:28 - Induction of longevity genes via xenohormesis
00:16:19 - Contradictory effects on exercise-associated benefits
00:20:34 - Various factors that affect resveratrol bioavailability
00:23:09 - Unintentional effects on drug metabolism
no apparent mention that Resveratrol increases the Vitamin D Receptor
Resveratrol overview at Examine.com July 2024
- "The therapeutic dose of resveratrol ranges from 8.1 mg per day to 3,000 mg per day.
Studies in humans suggest resveratrol can be supplemented at dosages up to 5 grams (5,000 mg) daily with few to no side effects outside of some intestinal upset and nausea."
Does not appear to mention that it is an activator of the Vitamin D receptor, nor mention the more bio-available forms of Resveratrol
RESVERATROL: REWRITING THE SCIENCE, Oct, 2018: by Bill Sardi
Chart of Resveratrol benefits - Natural Biology
Resveratrol, being a phytoestrogen, DECREASED Breast Cancer survival by 19% - Nov 2019
Resveratrol oral and topical forms that are more bio-available
Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update - July 2019
Download the PDF from VitaminDWiki
No mention of the Vitamin D Receptor
- - - - - -- A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol - May 2021 oi: 10.1097/CEJ.0000000000000621
- Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
Asked ChatGPT: What are the downsides to taking Resveratrol - Dec 2023
Resveratrol, a polyphenol found in certain plants and fruits, is often taken as a supplement for its potential health benefits. However, like any supplement, resveratrol can have downsides and side effects, particularly at higher doses or when taken in certain circumstances:
- Gastrointestinal Issues: High doses of resveratrol can cause gastrointestinal side effects such as nausea, diarrhea, vomiting, and other digestive issues. These effects are generally associated with doses higher than those achievable through diet alone, often occurring with supplement consumption 1 2
- Drug Interactions: Resveratrol may interact with several medications. It can inhibit cytochrome 3A4, potentially causing interactions with a range of medications including HMG-CoA reductase inhibitors (used to lower cholesterol), calcium channel agonists, anti-arrhythmic agents, HIV protease inhibitors, immunosuppressants, antihistamines, and erectile dysfunction medications. Additionally, its natural blood pressure-lowering and anti-coagulant effects might interact with blood pressure medications, anti-platelet drugs, anticoagulants, and NSAIDs like aspirin and ibuprofen 3 4
- Estrogenic Effects: Resveratrol has shown both estrogen agonist and antagonist effects in cell culture studies, and its chemical structure is similar to synthetic estrogen agonists. This characteristic can be problematic for individuals with estrogen-dependent tumors, such as those found in prostate and breast cancers. These tumors have many estrogen receptors and rely on the hormone for growth. Hence, individuals at risk for tumor growth should be cautious about concentrated resveratrol supplements 5 6.
- Joint Pain and Tendinitis: Some people have reported joint pain and tendinitis with resveratrol use, commonly affecting the Achilles tendon and other joint areas, sometimes accompanied by tingling and numbness in limbs 7 8
- Other Potential Side Effects: These include jittery feelings similar to excessive caffeine intake, insomnia, flu-like symptoms such as muscle aches and cramps, blood in the urine, and, in rare cases, an increase in arthritis pain. These symptoms are not universally experienced and may vary from person to person 9.
It's important to note that while some of these side effects are more commonly reported, others are rare or based on anecdotal evidence. The overall safety and side effects can vary greatly depending on the individual, the dosage, and other factors such as concurrent medication use or existing health conditions. Always consult a healthcare professional before starting any new supplement regimen, including resveratrol, to ensure it is safe based on your personal health profile.
Turmeric is as Effective as 14 Drugs (Turmeric also increases VDR activation) - March 2021
Associations with: Vitamin D Receptor, Virus, Zinc, Omega-3, Vitamin C, Cognitive, Magnesium, Vitamin K, Curcumin, Boron
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Resveratrol improves health (Vitamin D receptor, etc.) - many studiesPrinter Friendly Follow this page for updates1736 visitors, last modified 10 Oct, 2024, This page is in the following categories (# of items in each category) - Vitamin D Binding Protein = GC has