Vitamin D, mast cells, bones, and allergies - Aug 2022

Biomedicines 2022, 10(8), 1877; https://doi.org/10.3390/biomedicines10081877
by Giuseppe Murdaca 1,*,†ORCID,Alessandro Allegra 2,*,†ORCID,Alessandro Tonacci 3ORCID,Caterina Musolino 2,Luisa Ricciardi 4 andSebastiano Gangemi 4 ITALY

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The immune system is made up by an extremely composite group of cells, whose regulated and harmonious activity is fundamental to maintain health. The mast cells are an essential effector of inflammatory response which is characterized by a massive release of mediators accumulated in cytoplasmic secretory granules. However, beyond the effects on immune response, mast cells can modify bone metabolism and are capable of intervening in the genesis of pathologies such as osteoporosis and osteopenia. Vitamin D is recognized to induce changes in bone metabolism, but it is also able to influence immune response, suppressing mast cell activation and IgE synthesis from B cells and increasing the number of dendritic cells and IL-10-generating regulatory T cells. Vitamin D deficit has been reported to worsen sensitization and allergic manifestations in several different experimental models. However, in clinical situations, contradictory findings have been described concerning the correlation between allergy and vitamin D deficit. The aim of this review was to analyze the close relationships between mast cells and vitamin D, which contribute, through the activation of different molecular or cellular activation pathways, to the determination of bone pathologies and the onset of allergic diseases.
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Is there an association between mast cells and Vitamin D? Asked Perplexity AI Dec 2024

Yes, there is a significant association between mast cells and Vitamin D. This relationship plays a crucial role in immune function, inflammation regulation, and mast cell stability.
Vitamin D's Impact on Mast Cells
Mast Cell Stabilization
Vitamin D has been shown to contribute to mast cell stabilization 1  7
When vitamin D binds to receptors on mast cells, it inhibits mast cell activation and helps stabilize these cells  1
This stabilization effect can lead to a reduction in the release of histamine and other inflammatory mediators, potentially alleviating symptoms associated with mast cell disorders.Immune Regulation
Vitamin D influences the immune response by suppressing mast cell activation and modulating the production of various immune components  3  6
It can promote the production of anti-inflammatory cytokines, such as IL-10, while reducing the release of pro-inflammatory mediators  2  4
Mechanisms of Action
Vitamin D Receptor (VDR) Interaction
Mast cells express vitamin D receptors (VDRs) 3  4
When vitamin D binds to these receptors, it initiates various cellular processes that contribute to mast cell stability and function regulation 7
.Molecular Pathways
Vitamin D influences several molecular pathways within mast cells:

  • It forms complexes with Lyn, inhibiting the binding of Lyn to FcεRI and MyD88 7
  • This interaction decreases the phosphorylation of Syk and reduces levels of MAPK and NF-κB 7
  • Vitamin D can also bind to the promoter of TNF-α, decreasing its expression in mast cells 7

Clinical Implications
Vitamin D Deficiency
Low levels of vitamin D may result in spontaneous mast cell activation  5  7
This suggests that maintaining adequate vitamin D levels is crucial for individuals with mast cell disorders or those prone to allergic reactions.Therapeutic Potential
The ability of vitamin D to stabilize mast cells and reduce inflammation presents potential therapeutic applications  2 6
Supplementation with vitamin D might be beneficial for individuals with mast cell activation syndrome, histamine intolerance, or other allergic conditions.
Research Findings
Studies have demonstrated that:

  • Vitamin D can increase IL-10 production in mast cells, which has anti-inflammatory effects  4
  • Mast cells can convert 25OHD3 to the active form of vitamin D (1α,25(OH)2D3), further contributing to their own regulation  6
  • UVB irradiation, which increases vitamin D production in the skin, can lead to mast cell-mediated reduction of skin inflammation, dependent on mast cell VDR expression 4

In conclusion, the relationship between mast cells and vitamin D is complex and multifaceted, with vitamin D playing a crucial role in mast cell stability, immune regulation, and inflammatory response modulation. This association underscores the importance of maintaining adequate vitamin D levels, especially for individuals with mast cell-related disorders.

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VitaminDWiki - Skin category contains

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106+ VitaminDWiki pages with ALLERG in title

This list is automatically updated

Items found: 105
Title Modified
Major reduction allergies and asthma if the child was born in a sunny season (in Paris in this case) – April 2024 20 Apr, 2024
Vitamin D, mast cells, bones, and allergies - Aug 2022 01 Feb, 2024
Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies 26 Jan, 2024
Food allergies associated with low Vitamin D - many studies 02 Sep, 2023
Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023 21 Jul, 2023
Overview Rare Allergic reaction to vitamin D 15 Jul, 2023
People allergic to Lanolin should not be allergic to vegan Vitamin D 20 Mar, 2023
Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023 15 Mar, 2023
Allergic to multiple foods: 4 in 10 kids, 5 in 10 adults (note: Vitamin D helps) - Dec 2022 06 Jan, 2023
Do you have symptoms of COVID, Flu , RSV, Colds, Allergy - Oct 2022 28 Oct, 2022
Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022 18 Oct, 2022
Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022 26 May, 2022
Small vitamin D doses while pregnant do not decrease infant allergies – meta-analysis Feb 2022 03 Feb, 2022
Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021 21 Aug, 2021
Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 04 Aug, 2021
Reasons why some Respiratory Allergy studies find that Vitamin D does not help much – June 2020 21 Jun, 2020
Found again – 400 IU of Vitamin D rarely provides any benefit (infant allergy in this case) – RCT June 2020 11 Jun, 2020
Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020 12 Jan, 2020
Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 31 Dec, 2019
Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019 30 Aug, 2019
Allergic reactions to Insect sting decreased by topical Vitamin D (frequent) 09 Aug, 2019
6 year-old children were 5X less likely to have food allergies if supplementing with vitamin D – July 2019 24 Jul, 2019
Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 23 Jul, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014 14 Jul, 2019
Children with allergies often depressed and anxious (low micro-nutrients, such as vitamin D, were not mentioned) – July 2019 10 Jul, 2019
6X as many people with allergic rhinitis were severely vitamin D deficient – Jan 2012 30 Jun, 2019
Peanut and Food allergies prevented by Vitamin D 26 Jun, 2019
Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017 24 Jun, 2019
Prevalence and Severity of Food Allergies Among US Adults (vitamin D is not mentioned) – Jan 2019 24 Jun, 2019
Prenatal Omega-3 somewhat reduced child allergies (should also reduce Omega-6) – RCT June 2018 17 Apr, 2019
Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019 24 Jan, 2019
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune... 145 slides- 2017 30 Dec, 2018
Allergy - Overview 18 Dec, 2018
Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018 04 Dec, 2018
Soy associated with food allergies in mice (perhaps Roundup) – Nov 2018 21 Nov, 2018
Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 02 Jul, 2018
Hypothesis: Allergic diseases have increased because of decreased vitamin D – Oct 2014 01 Jul, 2018
Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 02 Apr, 2018
Food allergies are associated with Vitamin D thru genes, etc. – March 2018 29 Mar, 2018
Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 31 Jan, 2018
Rare allergy to Vitamin D cured by progressive Desensitization - 2016 04 Nov, 2017
Milk – Vitamin D deficiency 2X more likely if lactose intolerant, milk allergy, or low fat milk – 2017 03 Nov, 2017
Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015 07 Aug, 2017
Increased cows milk allergy if Folic acid or Folate added to vitamin D during pregnancy – June 2016 05 Apr, 2017
Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017 19 Jan, 2017
Woman with rare allergy to vitamin D was desensitized in a single day – Dec 2016 21 Dec, 2016
Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016 16 Dec, 2016
Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 23 Aug, 2016
Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014 03 Aug, 2016
Does too much Vitamin D cause problems – possible for allergies, maybe for falls – Review June 2016 26 Jun, 2016
Food allergies and low vitamin D – thymus may be the connection – June 2016 17 Jun, 2016
More childhood allergies when vitamin D is less than 15 ng – Feb 2011 17 Jun, 2016
3X more allergy to peanuts if child born with low UV – Feb 2011 17 Jun, 2016
Still unsure of association between vitamin D and asthma and allergies – review April 2012 17 Jun, 2016
Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel – Dec 2011 17 Jun, 2016
Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014 17 Jun, 2016
Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015 17 Jun, 2016
Food allergies 6 times higher in South Australia - 2009 28 May, 2016
11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013 17 Apr, 2016
Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016 17 Apr, 2016
Increasing amount of omega-3 in mother’s milk resulted in fewer infant allergies – March 2016 04 Apr, 2016
New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 09 Mar, 2016
Photosensitivity (sun allergy) and vitamin D 26 Jan, 2016
Allergic to the sun (Polymorphic light eruption) – you may need UVB or vitamin D 26 Jan, 2016
Asthma associated with low vitamin D, independent of allergic status – Nov 2015 25 Nov, 2015
Allergic Rhinitis (hay fever) reduced by just 1,000 IU of vitamin D for 30 days – RCT Sept 2015 02 Nov, 2015
Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 22 Oct, 2015
Severe allergy (Anaphylaxis) is increasing and is associated with low vitamin D – Sept 2015 12 Sep, 2015
Huge increase in food allergies in Australia may be due to low vitamin D 05 Sep, 2015
Food allergy and low vitamin D – unsure – June 2013 02 Sep, 2015
Vitamin D, Vitamin A, or Vitamin E association with allergies and asthma – Feb 2012 22 Aug, 2015
Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015 16 Aug, 2015
High level of maternal vitamin D and infant food allergy – controversy 16 Aug, 2015
Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 01 Aug, 2015
Allergic rhinitis associated with less vitamin D in men yet more in women – Jan 2014 05 Jul, 2015
Off topic: Large dose of Vitamin A increased allergic reaction in girls by 1.8X – RCT May 2015 02 May, 2015
Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015 06 Jan, 2015
Allergies and low vitamin D strongly associated with night shift bakers– Sept 2014 26 Dec, 2014
Allergy to House dust mite greatly reduced by adding just 600 IU of vitamin D – RCT Nov 2014 14 Sep, 2014
One issue of Inflammation and Allergy-Drug Targets has vitamin D items behind paywall– June 2013 03 May, 2014
30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012 23 Apr, 2014
Perhaps wool allergy is the cause of some Vitamin D allergy 15 Apr, 2014
Being told you have allergies is associated with less than 10 ng vitamin D – Nov 2011 29 Jan, 2014
Vitamin D in Allergic and Immune Disorders - Nov 2013 18 Nov, 2013
Allergic rhinitis 56 percent more likely if low vitamin D – Nov 2013 23 Oct, 2013
Vitamin D supplements increased probability of allergic rhinitis by 66 percent - 2004 23 Oct, 2013
Is Vitamin D Supplementation Responsible for the Allergy Pandemic – May 2012 27 Jun, 2012
Food allergy 80 percent more likely if have certain genes and vitamin D deficient – Nov 2011 15 Jun, 2012
Vitamin D, Allergy, and genetics – June 2012 15 Jun, 2012
Vitamin D less than 15 ng associated with some allergies – Feb 2011 11 Jun, 2012
Crescendo of papers on Asthma, Allergy, and Vitamin D – Sept 2011 11 Jun, 2012
Allergic diseases in the elderly – Oct 2011 10 Jan, 2012
Vitamin D in asthma and allergy – editorial Dec 2011 05 Dec, 2011
Allergies and bone health may be connected by vitamin D – Sept 2011 31 Aug, 2011
Hypothesis - vitamin D supplements caused allergy pandemic – 2009 04 Aug, 2011
Are microbs – probiotics – vitamin D – allergy – asthma – obesity related – Mar 2011 20 Jul, 2011
Vitamin D and allergy to common mold - Aug 2010 27 Mar, 2011
2X more allergies if 11th womb week was in Spring – Vitamin D or pollen Oct 2010 20 Oct, 2010
Review of vitamin D asthma and allergic diseases – abstract lacks details July 2010 20 Aug, 2010
Mechanisms for hypothesis between sunshine and food allergy - July 2010 07 Aug, 2010
Vitamin D may be linked to food allergies by intestinal flora – July 2010 20 Jul, 2010
Speculation on elderly Food Allergies and Vitamin D – June 2010 17 Jun, 2010
Winter babies are more prone to food allergies 25 Apr, 2010
Low vitamin D newborns getting cows milk formula more likely to get allergies – RCT Oct 2019 No value for 'modification_date_major'

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