Pediatric allergy therapy improved by 36 ng of Vitamin D – June 2023
Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy?
Annals of Medicine Volume 55, 2023 - Issue 1 https://doi.org/10.1080/07853890.2023.2230864
Mario Di Gioacchino,Claudia Petrarca,Loredana Della Valle, Rocco Mangifesta & Francesca Santilli
Significant improvement (#) in Vitamin D supplementation group
Vitamin D (VD) has been shown to exert immunomodulatory activities, especially in promoting immune tolerance. For these properties VD has been proposed in the therapy of immunological conditions in which the loss of tolerance is the key pathogenetic aspect of the disease, such as allergies. Despite these properties available literature suggests VD is not useful in treating or preventing allergic diseases and whether low serum VD levels favor allergic sensitization and severity is debated. The level of VD is one of the many conditions that can influence allergic sensitization and therefore only a multivariate analysis on a numerically adequate cohort of patients, that considers all the factors that can favor allergy, would be able to assign the weight of each variable and determine the extent to which VD inhibits allergic sensitization and march. On the contrary, VD is able to potentiate the antigen-specific tolerogenic response induced by Allergen Immunotherapy (AIT) as demonstrated by the large majority of studies. In our experience, the association of VD and Sublingual AIT (LAIS, Lofarma, Italy) gave an excellent clinical and immune response in particular enhancing the differentiation of memory T regulatory cells. While waiting for a more extensive literature, VD/AIT combination should be always performed in treating allergies. In any case, the assessment of the level of VD should become a routine in allergic patients with an indication to AIT as, in case of VD deficiency or insufficiency, VD seems a particularly active adjuvant to the immune treatment.
KEY MESSAGES
Allergic patients treated with allergen immunotherapy benefit from the simultaneous administration of Vitamin D, which on the contrary does not offer benefits when used alone for the prevention or treatment of allergies. Vitamin serum levels should be always evaluated in patients treated with allergen immunotherapy because these patients have the maximum clinical and immunological benefit from simultaneous vitamin D supplementation
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36+ VitaminDWiki Infant-Child pages with ALLERG in title
This list is automatically updated
Items found: 38
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Food allergy 4 X more likely in 2 year-old children with low Vitamin D – meta-analysis Feb 2023 |
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19 Mar, 2025 |
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Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023 |
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21 Jul, 2023 |
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Allergic rhinitis sublingual therapy was 22X more successful if good level of Vitamin D – Feb 2023 |
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15 Mar, 2023 |
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Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022 |
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18 Oct, 2022 |
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Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022 |
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26 May, 2022 |
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Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021 |
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21 Aug, 2021 |
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Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020 |
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12 Jan, 2020 |
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Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 |
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31 Dec, 2019 |
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Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019 |
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30 Aug, 2019 |
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6 year-old children were 5X less likely to have food allergies if supplementing with vitamin D – July 2019 |
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24 Jul, 2019 |
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Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019 |
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23 Jul, 2019 |
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Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014 |
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14 Jul, 2019 |
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Children with allergies often depressed and anxious (low micro-nutrients, such as vitamin D, were not mentioned) – July 2019 |
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10 Jul, 2019 |
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Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017 |
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24 Jun, 2019 |
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Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019 |
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24 Jan, 2019 |
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Allergy - Overview |
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18 Dec, 2018 |
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Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018 |
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04 Dec, 2018 |
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Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 |
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02 Apr, 2018 |
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Food allergies are associated with Vitamin D thru genes, etc. – March 2018 |
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29 Mar, 2018 |
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Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018 |
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31 Jan, 2018 |
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Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015 |
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07 Aug, 2017 |
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Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017 |
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19 Jan, 2017 |
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Childhood allergy, asthma and eczema associated with repeated low vitamin D tests – Oct 2016 |
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16 Dec, 2016 |
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Hay fever (allergic rhinitis) risk reduced 20 percent for each 100 IU of vitamin D during early pregnancy – Feb 2016 |
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23 Aug, 2016 |
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Food allergies and low vitamin D – thymus may be the connection – June 2016 |
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17 Jun, 2016 |
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More childhood allergies when vitamin D is less than 15 ng – Feb 2011 |
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17 Jun, 2016 |
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3X more allergy to peanuts if child born with low UV – Feb 2011 |
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17 Jun, 2016 |
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Still unsure of association between vitamin D and asthma and allergies – review April 2012 |
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17 Jun, 2016 |
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Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014 |
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17 Jun, 2016 |
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Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015 |
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17 Jun, 2016 |
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Food allergies 6 times higher in South Australia - 2009 |
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28 May, 2016 |
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11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013 |
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17 Apr, 2016 |
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Five times less mite allergy when vitamin D added in mid pregnancy and to infant – RCT April 2016 |
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17 Apr, 2016 |
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Increasing amount of omega-3 in mother’s milk resulted in fewer infant allergies – March 2016 |
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04 Apr, 2016 |
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Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014 |
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22 Oct, 2015 |
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Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015 |
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16 Aug, 2015 |
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High level of maternal vitamin D and infant food allergy – controversy |
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16 Aug, 2015 |
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30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012 |
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23 Apr, 2014 |
31+ VitaminDWiki pages with both FOOD AND ALLERGIES in the title
This list is automatically updated
Items found: 31
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Allergic diseases (dermatitis, rhinitis, asthma, food) and Vitamin D - many studies |
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19 Mar, 2025 |
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Food allergy 4 X more likely in 2 year-old children with low Vitamin D – meta-analysis Feb 2023 |
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19 Mar, 2025 |
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Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies |
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26 Jan, 2024 |
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Food allergies associated with low Vitamin D - many studies |
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02 Sep, 2023 |
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Allergic to multiple foods: 4 in 10 kids, 5 in 10 adults (note: Vitamin D helps) - Dec 2022 |
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06 Jan, 2023 |
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Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020 |
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12 Jan, 2020 |
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6 year-old children were 5X less likely to have food allergies if supplementing with vitamin D – July 2019 |
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24 Jul, 2019 |
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Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 |
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17 Jul, 2019 |
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Peanut and Food allergies prevented by Vitamin D |
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26 Jun, 2019 |
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Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017 |
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24 Jun, 2019 |
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Prevalence and Severity of Food Allergies Among US Adults (vitamin D is not mentioned) – Jan 2019 |
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24 Jun, 2019 |
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Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019 |
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24 Jan, 2019 |
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Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune... 145 slides- 2017 |
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30 Dec, 2018 |
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Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018 |
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04 Dec, 2018 |
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Soy associated with food allergies in mice (perhaps Roundup) – Nov 2018 |
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21 Nov, 2018 |
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Vitamin D and allergy, asthma, atopic dermatitis, food allergy, autoimmune, etc – slides May 2017 |
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02 Jul, 2018 |
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Food allergies are associated with Vitamin D thru genes, etc. – March 2018 |
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29 Mar, 2018 |
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Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015 |
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07 Aug, 2017 |
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Food allergies and low vitamin D – thymus may be the connection – June 2016 |
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17 Jun, 2016 |
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Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015 |
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17 Jun, 2016 |
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Food allergies 6 times higher in South Australia - 2009 |
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28 May, 2016 |
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Huge increase in food allergies in Australia may be due to low vitamin D |
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05 Sep, 2015 |
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Food allergy and low vitamin D – unsure – June 2013 |
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02 Sep, 2015 |
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Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015 |
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16 Aug, 2015 |
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High level of maternal vitamin D and infant food allergy – controversy |
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16 Aug, 2015 |
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Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 |
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01 Aug, 2015 |
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Food allergy 80 percent more likely if have certain genes and vitamin D deficient – Nov 2011 |
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15 Jun, 2012 |
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Mechanisms for hypothesis between sunshine and food allergy - July 2010 |
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07 Aug, 2010 |
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Vitamin D may be linked to food allergies by intestinal flora – July 2010 |
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20 Jul, 2010 |
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Speculation on elderly Food Allergies and Vitamin D – June 2010 |
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17 Jun, 2010 |
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Winter babies are more prone to food allergies |
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25 Apr, 2010 |