Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020

Acta Histochem Cytochem. 2020 Jun 26;53(3):33-42. doi: 10.1267/ahc.20011
Nuraly S Akimbekov 1, Ilya Digel 2, Dinara K Sherelkhan 1, Afzalunnessa B Lutfor 3, Mohammed S Razzaque 4

VitaminDWiki

Microbiome category listing has 38 items along with related searches
Gut Microbiota: improved by Vitamin D – narrative review – July 2021
Vitamin D is aided by probiotics (review of RCTs) – Dec 2020
Antibiotics and Vitamin D are associated with many of the same diseases
- Note: antibiotics kills many friendly microbes
Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019
Prediabetics had different gut bacteria – April 2018
Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018

Overview Gut and vitamin D has the following summary

Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
All items in category gut and vitamin D 207 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio	Form	Speed	Duration
10	Injection ($$$) or Calcidiol or Calcitriol	D - Slow C -Fast	Long
10	Sun/UVB	Slow	Long
10	Topical (skin patch/cream, vagina)	Slow Fast nano	Normal
9	Nanoemulsion -mucosal perhaps activates VDR	Fast	Normal
9?	Inhaled (future)	Fast	Normal
8	Bio-D-Mulsion Forte	Normal	Normal
6	Water soluble (Bio-Tech)	Normal	Normal
4	Sublingual/spray (some goes into gut)	Fast	Normal
3	Coconut oil based	Slow	Normal
2	Food (salmon etc.)	Slow	Normal
2	Olive oil based (majority)	Slow	Normal

Bio Form Speed Duration
10 Injection ($$$)
or Calcidiol or Calcitriol D - Slow
C -Fast Long
10 Sun/UVB Slow Long
10 Topical
(skin patch/cream, vagina) Slow
Fast nano Normal
9 Nanoemulsion -mucosal
perhaps activates VDR Fast Normal
9? Inhaled (future) Fast Normal
8 Bio-D-Mulsion Forte Normal Normal
6 Water soluble (Bio-Tech) Normal Normal
4 Sublingual/spray
(some goes into gut) Fast Normal
3 Coconut oil based Slow Normal
2 Food (salmon etc.) Slow Normal
2 Olive oil based (majority) Slow Normal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Download the PDF from VitaminDWiki
__Likely Gut Microbiota Functions__

There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.