Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024

A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age

Geroscience. 2024 Mar 26. doi: 10.1007/s11357-024-01138-8 – PDF behind paywall, but can be seen in DeepDyve
Kirsty C McGee 1, Jack Sullivan 1, Jon Hazeldine 1, Lisa J Schmunk 2, Daniel E Martin-Herranz 2, Thomas Jackson 1 3, Janet M Lord 4 5

An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults. We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49). Blood and saliva were obtained pre and post a 12-week course of a multi-component supplement, containing:

  • Vitamin B3,
  • Vitamin C,
  • Vitamin D,
  • Omega 3 fish oils,
  • Resveratrol,
  • Olive fruit phenols and
  • Astaxanthin.

Plasma GDF-15 and C-reactive protein (CRP) concentrations were quantified as markers of biological aging and inflammation respectively. DNA methylation was assessed in whole blood and saliva and used to derive epigenetic age using various clock algorithms.No difference between the epigenetic and chronological ages of participants was observed pre- and post-treatment by the blood-based Horvath or Hannum clocks, or the saliva-based InflammAge clock. However, in those with epigenetic age acceleration of ≥ 2 years at baseline, a significant reduction in epigenetic age (p = 0.015) and epigenetic age acceleration (p = 0.0058) was observed post-treatment using the saliva-based InflammAge clock. No differences were observed pre- and post-treatment in plasma GDF-15 and CRP, though participants with CRP indicative of an elevated cardiovascular disease risk (hsCRP ≥ 3µg/ml), had a reduction in CRP post-supplementation (p = 0.0195).Our data suggest a possible benefit of combined nutritional supplementation in individuals with an accelerated epigenetic age and inflammaging.

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VitaminDwiki – Epigenetics and Vitamin D – many studies

VitaminDwiki – Longevity and healthspan increased by Vitamin D, Omega-3, Magnesium - many studies

VitaminDWiki – Inflammation category contains:

175 items total

Example studies

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38+ VitaminDWiki pages have AGING in the title

This list is automatically updated

Items found: 39
Title Modified
Life extension by physical activity or more than 34 ng of Vitamin D – together they reduce aging by 1.3 years – July 2024 13 Jun, 2024
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Vitamin D and Aging: Central Role of Immunocompetence – Carlberg Jan 2024 21 Mar, 2024
The Science of Magnesium and Its Role in Aging and Disease - Patrick March 2024 20 Mar, 2024
Vitamin K can reduce aging - April 2021 25 Dec, 2023
Vitamin D reduces aging and prevents disease (less oxidative stress) - Dec 2022 07 Dec, 2022
Aging of the Immune system (Immunosenescence): micronutrients and gut microbiota – Oct 2022 03 Oct, 2022
Age of menopause increases if add vitamin D or UVB 25 Aug, 2021
Several advanced-maternal-age problems reduced if given Vitamin D during pregnancy (mice in this case) – July 2021 11 Aug, 2021
Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017 17 May, 2021
Poorer sleep as Vitamin D levels drop with age – March 2021 20 Feb, 2021
Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020 07 Oct, 2020
Boys who were born Small for Gestational age are 1.9X more likely to be infertile – Dec 2019 20 Dec, 2019
Preterm birth increases risk of heart disease by 1.5 X by age 40 – June 2019 06 Aug, 2019
Low Vitamin D is one of the causes of oxidative stress and aging – March 2019 15 May, 2019
Medicaid pays for 70 percent of US pregnancies for women under age 25 – April 2019 25 Apr, 2019
Far healthier and stronger at age 72 due to supplements 27 Jan, 2019
Off Topic: Premature birth results in less schooling and income (age 28, 228,000 Danes) – Dec 2018 15 Dec, 2018
Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015 27 Jun, 2018
Half as many Small for Gestational Age infants when take 600 IU of vitamin D while pregnant – June 2018 27 Jun, 2018
Vitamin D reduced so low that Victorian age diseases are returning 05 Apr, 2018
Vitamin D gene expression varies with Epileptic age – March 2018 20 Mar, 2018
Prematurely aging kids (Hutchinson-Gilford Progeria Syndrome) might be helped by Vitamin D– March 2018 20 Mar, 2018
Hypothesis – less vitamin D results in faster aging – Nov 2017 17 Nov, 2017
The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018 21 Oct, 2017
Genes which regulate active vitamin D worsen with age – Oct 2016 31 Oct, 2016
Small for gestational age with low vitamin D – 3.6X higher for blacks than whites – April 2016 21 Apr, 2016
Anti-aging Effect of Magnesium on Telomeres (in rats) - Mar 2014 15 Apr, 2016
Obese of all ages have lower levels of vitamin D – meta-analysis May 2015 10 May, 2015
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
Understanding vitamin D deficiency - Editorial in Age and Ageing July 2014 02 Aug, 2014
Vitamin D deficiency in Rheumatology clinics in Iran (D increases with age)– May 2013 02 Nov, 2013
Huge variation in taking vitamin D supplements with age of female, less than 1000 IU not help much – July 2013 29 Aug, 2013
Unspecified differences in vitamin D at age 10 failed to predict intelligence at age 15 – April 2012 13 Apr, 2012
Appears that some CNS ageing problems can be avoided with vitamin D – July 2010 06 Oct, 2011
Forum on Aging and Skeletal Health – Sept 2011 17 Sep, 2011
Kidney aging-inevitable or preventable – Aug 2011 25 Aug, 2011
Amylase increases with age, as does weight 10 Aug, 2010
How much calcidiol or calcitriol is needed to slow aging in mice – 2009 02 Jul, 2010


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