Water-dispersible forms of vitamins A, D, E and K are better

For best results, many supplements should be taken in water-dispersible forms
     such as: all of the fat soluble vitamins, Omega-3, Resveratrol, Glutathione, etc.
1) More bioavailable (see below: +10% to +50%)
2) Not need to take the supplement with a fatty meal
3) Gets the supplement into the bloodstream without a ~12-hour delay of the Lymph System
    topical forms, such as Vitamin D nano-emulsions, are even faster
4) Water-dispersible forms are more gut-friendly -see below

Increased bioavailability, especially when taken without a fatty meal

Data from Perplexity AI - Oct 9, 2024

Water-dispersible With a
fatty meal		Without a
fatty meal
Vitamin A10-20% 130-50% 1
Vitamin D 15-25% 2 40-60% 2
Vitamin E5-15% 3 25-40% 3
Vitamin K10-30% 1 35-55% 1
Factors Affecting Bioavailability

Several factors influence the bioavailability of fat-soluble vitamins:

  1. Formulation: The specific water-dispersible technology used can impact bioavailability   3
  2. Individual physiology: Factors like age, gut health, and bile production affect absorption  2
  3. Dosage: Higher doses may not necessarily lead to proportionally higher absorption  1
  4. Concurrent nutrient intake: The presence of other nutrients can influence absorption   3

Implications for Supplementation
Water-dispersible forms of fat-soluble vitamins offer several advantages:

  • Improved absorption: Especially beneficial for individuals with fat malabsorption issues   2
  • Flexibility in timing: Can be taken without food while maintaining good bioavailability   1
  • Reduced risk of toxicity: Better control over absorption may lower the risk of excessive accumulation   3

However, it's important to note that while water-dispersible forms generally show improved bioavailability, they do not eliminate the need for proper dosing and consideration of individual health factors. Consulting with a healthcare professional is always recommended when considering vitamin supplementation.

Are water-dispersible forms of supplements more gut-friendly?

Water-dispersible forms of supplements are generally considered more gut-friendly compared to non-dispersible forms. Here's why:
Benefits of Water-Dispersible Supplements
Improved Solubility
Water-dispersible supplements dissolve or disperse more easily in the digestive tract, which can provide several advantages:

  • They mix more readily with stomach contents  1
  • They move more smoothly through the digestive system   1
  • They may cause less irritation to the gut lining   1

Enhanced Absorption
The increased solubility of water-dispersible forms can lead to better absorption in the gastrointestinal tract. This means the nutrients are more readily available for the body to utilize.
Gentler on the Digestive System
Water-dispersible supplements tend to be less abrasive compared to non-dispersible forms. This characteristic makes them:

  • Less likely to cause bloating or gas   2
  • Easier for those with sensitive digestive systems to tolerate   2
  • Potentially more suitable for people with certain gastrointestinal conditions   2

Comparison to Non-Dispersible Forms
While non-dispersible supplements have their own benefits, they can sometimes be more challenging for the digestive system to process. Water-dispersible forms may offer a gentler alternative, especially for those new to taking supplements or those with sensitive digestive tracts.

Practical Implications
When choosing supplements, opting for water-dispersible forms may be a good strategy, particularly if you're concerned about digestive comfort. However, it's important to note that the effectiveness of a supplement depends on various factors, including its formulation and your individual needs. Remember to increase supplement intake gradually and drink plenty of water to help your digestive system adjust. As always, consult with a healthcare professional before making significant changes to your supplement regimen, especially if you have existing digestive issues.

Some of the Amazon suppliers with water-dispersible, high dose Vitamin D

Many have smaller doses and combinations with Vitamin K

6+ VitaminDWiki pages have WATER (SOLUBLE OR DISPERSIBLE) in the title

The list is automatically updated

Items found: 6

Cyclodextrin is yet another way to make fat-soluble vitamins water dispersible

Have found studies but no comerical product using it as of Oct 2024
Have NOT looked at the following studies

  • Unraveling the Catalytic Mechanism of β-Cyclodextrin in the Vitamin D Formation - April 2024 https://doi.org/10.1021/acs.jcim.3c02049
  • Developing New Cyclodextrin-Based Nanosponges Complexes to Improve Vitamin D Absorption in an In Vitro Study = March 2023 FREE PDF
  • Cyclodextrin about 15 studies
  • Development of gelatin-coated nanoliposomes loaded with β-cyclodextrin/vitamin D3 inclusion complex for nutritional therapy - Oct 2023 https://doi.org/10.1016/j.foodchem.2023.136346
  • Fat-Soluble Vitamin Supplementation Using Liposomes, Cyclodextrins, or Medium-Chain Triglycerides in Cystic Fibrosis: A Randomized Controlled Trial - Dec 2021 FREE PDF shows 2X-3X increase bio-availability for Cystic Fibrosis
    • Keywords: cystic fibrosis; vitamin A; retinol; vitamin D; cholecalciferol; vitamin E; tocopherol; vitamin K; menaquinone; liposome; cyclodextrin
  • Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut–Brain Axes in Physiology and IBS Syndrome - Feb 2024 FREE PDF
  • Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status - April 2024 https://doi.org/10.1007/s13346-024-01586-x

Similar benefits?: Water-dispersible, water-soluble, emulsion, nanoemulsion, spray, liposomal, sublingual

Please send an email if one form does not share bio-availability or is not gut-friendly: hlahore@gmail.com

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