Afib in Finland reduced 30% by Vitamin D (3200 IU) – RCT June 2023

The effect of vitamin D3 supplementation on atrial fibrillation in generally healthy men and women: The Finnish Vitamin D Trial

American Heart Journal https://doi.org/10.1016/j.ahj.2023.05.024
Jyrki K. Virtanen PhD a, Sari Hantunen PhD a, Christel Lamberg-Allardt PhD b, JoAnn E. Manson MD, DrPH c d, Tarja Nurmi PhD a, Matti Uusitupa MD, PhD a, Ari Voutilainen PhD a, Tomi-Pekka Tuomainen MD, PhD a

Image

Atrial fibrillation is a common cardiac arrhythmia with high morbidity risk. Observational studies suggest that vitamin D deficiency is associated with higher atrial fibrillation risk but there is limited evidence whether vitamin D supplementation could affect the risk. In these post hoc analyses from the Finnish Vitamin D Trial, we compared the incidence of atrial fibrillation with 5-year supplementation of vitamin D3 (1600 IU/d or 3200 IU/d) vs placebo.

Clinical Trial Registry number:ClinicalTrials.gov: NCT01463813, https://clinicaltrials.gov/ct2/show/NCT01463813

Background
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adulthood, increasing in prevalence with age and carrying a major burden of morbidity. Therefore, with aging populations, methods to decrease AF risk are needed.

Mechanistic studies suggest a role for vitamin D deficiency in the pathogenesis of AF,1 and in observational studies vitamin D deficiency has been associated with increased AF risk.2 However, only a few randomized clinical trials (RCT) have investigated whether vitamin D supplementation could reduce AF risk in general populations. In the Women's Health Initiative (WHI), vitamin D3 supplementation of 400 IU/d with calcium 1,000 mg/d for a mean 4.3 years did not have an effect on the AF risk.3 Similarly, in the recent Vitamin D and Omega-3 Trial (VITAL) Rhythm Study, supplementation with 2,000 IU/d of vitamin D3 did not affect the AF risk over 5.3 years.4

The aim of the current analysis was to investigate the effects of 5-year vitamin D3 supplementation with 1,600 IU/d or 3,200 IU/d on AF risk, compared to placebo, among generally healthy men and women in the Finnish Vitamin D Trial (FIND).
 Download the PDF from VitaminDWiki

Note: Finns already have a high level of vitamin D

After years of adding vitamin D, Finland now has 38 ng levels - March 2022

23+ VitaminDWiki pages with AFIB or FIBRILATION in title

This list is automatically updated

Items found: 24
Title Modified
Afib implants (cardiac resynchronization therapy) are 3X less likely to help if low vitamin D – July 2024 15 Aug, 2024
Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 11 Jul, 2023
Afib in Finland reduced 30% by Vitamin D (3200 IU) – RCT June 2023 09 Jul, 2023
Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023 27 May, 2023
Atrial Fibrillation - now 1 in 45 in the UK - May 2023 26 May, 2023
Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022 13 Nov, 2022
Atrial Fibrillation risk reduced by 0.84 in those raising Vitamin D levels above 30 ng – RCT April 2022 04 Apr, 2022
Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018 16 Jan, 2019
Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues 14 Dec, 2018
Osteoporosis treatment with Vitamin D – far healthier and 10X fewer afib events (vs bisphosphonates) – Oct 2018 30 Oct, 2018
Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem) – Aug 2018 14 Oct, 2018
Atrial fibrillation - Vitamin D improved 1 of 4 measures – March 2015 27 Jun, 2018
Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018 27 Jun, 2018
Atrial Fibrillation strongly associated with some vitamin D binding protein – Dec 2017 09 Dec, 2017
Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016 15 Oct, 2017
Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015 10 Dec, 2016
Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016 26 Sep, 2016
Atrial fibrillation and low vitamin D: both types of AF are very low – Jan 2014 01 Nov, 2015
Atrial Fibrillation - remineralize your heart - Aug 2015 25 Oct, 2015
Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015 02 Sep, 2015
Atrial fibrillation reduced with modest vitamin D levels (did not consider Magnesium) – May 2015 05 May, 2015
Higher vitamin D levels associated with health and lower risk of atrial fibrillation – May 2015 02 May, 2015
Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014 13 Feb, 2015
Atrial Fibrillation associated with lower levels of vitamin D – July 2012 13 Dec, 2013

- - - - See also 4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023

Adding Omega-3 would probably help reduce AFIB

VitaminDWiki - 34 studies in both categories Cardiovascular and Omega-3

This list is automatically updated

There have been 5136 visits to this page


4865 visitors, last modified 09 Jul, 2023,
Printer Friendly Follow this page for updates