Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients.
Nutr Clin Pract. 2019 Oct 11. doi: 10.1002/ncp.10407.
Most groups taking high-dose vitamin D do one or more of the following:
- Increase Magnesium
- Increase Vitamin K
- Reduce Calcium intake - especially pills
- Increase Water
The founder of VitaminDWiki takes 20,000 IU Vitamin D average along with Magnesium and Vitamin K
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Hypercalcemia in critically ill patients taking 10,000 IU of vitamin D (many solutions) – Oct 2019
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Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
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Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019
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Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
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Vitamin D Cofactors in a nutshell
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Vascular calcification greatly reduced by 3 per week 1000 ug of Vitamin K2 MK-7 – Dec 2013
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Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
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Review of Micronutrients such as vitamin D for women and childhood – Aug 2013
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Healthy bones need Ca, Silicon, Vitamins B, C, D, and K – Dec 2012
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Interview of Vitamin K2 and Calcium Paradox author by Dr. Mercola – Dec 2012
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Vitamin K2 and the Calcium Paradox – 2012 book
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Low cost cofactors for vitamin D
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Postmenopausal women should supplement vitamins C D K and Calcium – June 2010
27 Items in both categories Calcium and Magnesium:
-
Which supplements are often taken for healing hairline bone fractures
-
Less Calcification if less Calcium or more Vitamin K, Magnesium, etc. - many studies
-
You are probably unaware that health needs a Ca-Mg ratio of 2 – Sept 2022
-
Calcium to Magnesium Ratio - many studies
-
COVID treatment patent applied for - using Rutin, Vitamin D, Vitamin C, Magnesium, etc. – April 2022
-
Excellent reviews of supplements at ConsumerLab
-
Increased dental decay if take Calcium without Magnesium – Feb 2020
-
Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
-
Colorectal Cancer risk increases 1.6 X if high Calcium, low Magnesium and a poor gene – Sept 2007
-
Mineral adsorption and Vitamin D (Magnesium, Calcium, etc) - 2011
-
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
-
Natural variation in mineral content of a food is typically 3 to 1 – Nov 2016
-
Interactions between Magnesium, Vitamin D, and Calcium – April 2016
-
Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
-
Vitamin D - Comparing Symptoms of Hypercalcemia with Low Magnesium - Sept 2015
-
Vitamin D Cofactors in a nutshell
-
Vitamin D increases mineral availability which protect against toxic elements - July 2015
-
Stronger bones after 3 generations of tap water (more Ca and Mg) vs bottled water – March 2015
-
Magnesium may be more important to kids’ bone health than calcium – May 2013
-
Calcium 2X of Magnesium seems good – China Feb 2013
-
RDA upper limit etc for Vitamin D and Magnesium - Sept 2011
-
Weight loss and Vitamin D, Calcium, and Magnesium
-
Decrease Calcium and Increase Magnesium when increasing vitamin D
-
400 IU of vitamin D Magnesium and Calcium helped Twin bones – Feb 2011
-
Low cost cofactors for vitamin D
-
Constipation - Magnesium, Calcium and cofactors
-
Calcium in food increased much more than Magnesium in recent decades April 2010
- Hypercalcemia and Vitamin D - many studies
- Increased Calcium decreases Vitamin D in males – Nov 2020
- No correlation found between hypercalcemia and high level of vitamin D – March 2021
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
- IoM again fails to look at interactions - Nov 2010
- has the graph: dangerous to have too much Calcium while having lots of vitamin D
Holmes WL1, Maish GO 3rd2, Minard G2, Croce MA2, Dickerson RN3.
1 Department of Pharmacy, Regional One Health, Memphis, Tennessee, USA.
2 Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
3 Dept of Clinical Pharmacy and Translational Science, U. of Tennessee Health Science Center, Memphis, TN, USA.
BACKGROUND:
Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients.
METHODS:
Fifty-three patients (>17 years of age) admitted to the trauma intensive care unit who had a serum 25-hydroxy vitamin D (25-OH vit D) concentration <20 ng/mL were given 10,000 IU of cholecalciferol daily. Efficacy was defined as achievement of a 25-OH vit D of 30-79.9 ng/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] >1.32 mmol/L) or hypervitaminosis D (25-OH vit D >79.9 nmol/L). Patients were monitored for 2 weeks during cholecalciferol therapy.
RESULTS:
Twenty-four patients (45%) achieved target 25-OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa >1.49 nmol/L. 25-OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6 ng/mL, respectively, P < 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25-OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25-OH vit D (P = 0.024).
CONCLUSIONS:
Cholecalciferol normalized serum 25-OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.
There have been 4676 visits to this page
47 visitors, last modified 22 Jun, 2024,
Printer Friendly
Follow this page for updates
- Which supplements are often taken for healing hairline bone fractures
- Calcium and Vitamin K2 - many studies
- Excellent reviews of supplements at ConsumerLab
- Lowering Calcium Risk when having High Dose Vitamin D3 – Cawley Dec 2019
- Hypercalcemia in critically ill patients taking 10,000 IU of vitamin D (many solutions) – Oct 2019
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Calcium supplements go to muscle, not bone, unless have enough Vitamin K – Feb 2019
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Vitamin D Cofactors in a nutshell
- Vascular calcification greatly reduced by 3 per week 1000 ug of Vitamin K2 MK-7 – Dec 2013
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Review of Micronutrients such as vitamin D for women and childhood – Aug 2013
- Healthy bones need Ca, Silicon, Vitamins B, C, D, and K – Dec 2012
- Interview of Vitamin K2 and Calcium Paradox author by Dr. Mercola – Dec 2012
- Vitamin K2 and the Calcium Paradox – 2012 book
- Low cost cofactors for vitamin D
- Postmenopausal women should supplement vitamins C D K and Calcium – June 2010
27 Items in both categories Calcium and Magnesium:
-
Which supplements are often taken for healing hairline bone fractures
-
Less Calcification if less Calcium or more Vitamin K, Magnesium, etc. - many studies
-
You are probably unaware that health needs a Ca-Mg ratio of 2 – Sept 2022
-
Calcium to Magnesium Ratio - many studies
-
COVID treatment patent applied for - using Rutin, Vitamin D, Vitamin C, Magnesium, etc. – April 2022
-
Excellent reviews of supplements at ConsumerLab
-
Increased dental decay if take Calcium without Magnesium – Feb 2020
-
Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
-
Colorectal Cancer risk increases 1.6 X if high Calcium, low Magnesium and a poor gene – Sept 2007
-
Mineral adsorption and Vitamin D (Magnesium, Calcium, etc) - 2011
-
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
-
Natural variation in mineral content of a food is typically 3 to 1 – Nov 2016
-
Interactions between Magnesium, Vitamin D, and Calcium – April 2016
-
Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
-
Vitamin D - Comparing Symptoms of Hypercalcemia with Low Magnesium - Sept 2015
-
Vitamin D Cofactors in a nutshell
-
Vitamin D increases mineral availability which protect against toxic elements - July 2015
-
Stronger bones after 3 generations of tap water (more Ca and Mg) vs bottled water – March 2015
-
Magnesium may be more important to kids’ bone health than calcium – May 2013
-
Calcium 2X of Magnesium seems good – China Feb 2013
-
RDA upper limit etc for Vitamin D and Magnesium - Sept 2011
-
Weight loss and Vitamin D, Calcium, and Magnesium
-
Decrease Calcium and Increase Magnesium when increasing vitamin D
-
400 IU of vitamin D Magnesium and Calcium helped Twin bones – Feb 2011
-
Low cost cofactors for vitamin D
-
Constipation - Magnesium, Calcium and cofactors
-
Calcium in food increased much more than Magnesium in recent decades April 2010
- Hypercalcemia and Vitamin D - many studies
- Increased Calcium decreases Vitamin D in males – Nov 2020
- No correlation found between hypercalcemia and high level of vitamin D – March 2021
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
- IoM again fails to look at interactions - Nov 2010
- has the graph: dangerous to have too much Calcium while having lots of vitamin D
Holmes WL1, Maish GO 3rd2, Minard G2, Croce MA2, Dickerson RN3.
1 Department of Pharmacy, Regional One Health, Memphis, Tennessee, USA.
2 Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
3 Dept of Clinical Pharmacy and Translational Science, U. of Tennessee Health Science Center, Memphis, TN, USA.
BACKGROUND:
Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients.
METHODS:
Fifty-three patients (>17 years of age) admitted to the trauma intensive care unit who had a serum 25-hydroxy vitamin D (25-OH vit D) concentration <20 ng/mL were given 10,000 IU of cholecalciferol daily. Efficacy was defined as achievement of a 25-OH vit D of 30-79.9 ng/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] >1.32 mmol/L) or hypervitaminosis D (25-OH vit D >79.9 nmol/L). Patients were monitored for 2 weeks during cholecalciferol therapy.
RESULTS:
Twenty-four patients (45%) achieved target 25-OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa >1.49 nmol/L. 25-OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6 ng/mL, respectively, P < 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25-OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25-OH vit D (P = 0.024).
CONCLUSIONS:
Cholecalciferol normalized serum 25-OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.
There have been 4676 visits to this page
47 visitors, last modified 22 Jun, 2024,
Printer Friendly
Follow this page for updates
- Which supplements are often taken for healing hairline bone fractures
- Less Calcification if less Calcium or more Vitamin K, Magnesium, etc. - many studies
- You are probably unaware that health needs a Ca-Mg ratio of 2 – Sept 2022
- Calcium to Magnesium Ratio - many studies
- COVID treatment patent applied for - using Rutin, Vitamin D, Vitamin C, Magnesium, etc. – April 2022
- Excellent reviews of supplements at ConsumerLab
- Increased dental decay if take Calcium without Magnesium – Feb 2020
- Off topic: Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.
- Colorectal Cancer risk increases 1.6 X if high Calcium, low Magnesium and a poor gene – Sept 2007
- Mineral adsorption and Vitamin D (Magnesium, Calcium, etc) - 2011
- Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
- Natural variation in mineral content of a food is typically 3 to 1 – Nov 2016
- Interactions between Magnesium, Vitamin D, and Calcium – April 2016
- Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
- Vitamin D - Comparing Symptoms of Hypercalcemia with Low Magnesium - Sept 2015
- Vitamin D Cofactors in a nutshell
- Vitamin D increases mineral availability which protect against toxic elements - July 2015
- Stronger bones after 3 generations of tap water (more Ca and Mg) vs bottled water – March 2015
- Magnesium may be more important to kids’ bone health than calcium – May 2013
- Calcium 2X of Magnesium seems good – China Feb 2013
- RDA upper limit etc for Vitamin D and Magnesium - Sept 2011
- Weight loss and Vitamin D, Calcium, and Magnesium
- Decrease Calcium and Increase Magnesium when increasing vitamin D
- 400 IU of vitamin D Magnesium and Calcium helped Twin bones – Feb 2011
- Low cost cofactors for vitamin D
- Constipation - Magnesium, Calcium and cofactors
- Calcium in food increased much more than Magnesium in recent decades April 2010
- Hypercalcemia and Vitamin D - many studies
- Increased Calcium decreases Vitamin D in males – Nov 2020
- No correlation found between hypercalcemia and high level of vitamin D – March 2021
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
- IoM again fails to look at interactions - Nov 2010
- has the graph: dangerous to have too much Calcium while having lots of vitamin D
Holmes WL1, Maish GO 3rd2, Minard G2, Croce MA2, Dickerson RN3.
1 Department of Pharmacy, Regional One Health, Memphis, Tennessee, USA.
2 Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
3 Dept of Clinical Pharmacy and Translational Science, U. of Tennessee Health Science Center, Memphis, TN, USA.
BACKGROUND:
Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients.
METHODS:
Fifty-three patients (>17 years of age) admitted to the trauma intensive care unit who had a serum 25-hydroxy vitamin D (25-OH vit D) concentration <20 ng/mL were given 10,000 IU of cholecalciferol daily. Efficacy was defined as achievement of a 25-OH vit D of 30-79.9 ng/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] >1.32 mmol/L) or hypervitaminosis D (25-OH vit D >79.9 nmol/L). Patients were monitored for 2 weeks during cholecalciferol therapy.
RESULTS:
Twenty-four patients (45%) achieved target 25-OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa >1.49 nmol/L. 25-OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6 ng/mL, respectively, P < 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25-OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25-OH vit D (P = 0.024).
CONCLUSIONS:
Cholecalciferol normalized serum 25-OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.
There have been 4676 visits to this page
47 visitors, last modified 22 Jun, 2024,
Printer Friendly
Follow this page for updates
47 visitors, last modified 22 Jun, 2024, |