Omega-3 proven to provide many benefits in 5 year VITAL trial - Nov 2018

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Summary of trial by Grassrootshealth

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Same information as above,
but includes probability information and can be translated to other languages

Statistically Significant Omega-3 Results from
Pre-specified Secondary Outcomes and Subgroup Analyses
p <0.05 for the association to be probable
Smaler p = more probable

Omega-3 vs. Placebo Secondary Outcomes	Reduced Risk	p
Heart Attack	28%	p=0.002)
Major CVD event (heart attack, stroke, or death from cardiovascular cause)
Fish consumption <1.5 servings/wk	19%	p=0.03)
African Americans with <1.5 servings of fish/wk	39%	p=0.049)
Secondary Outcomes - Subgroup Analyses Heart Attack
African Americans	77%	p=<0.0001)
African Americans with diabetes	94%	p=0.005)
African Americans with 1 cardiovascular risk factor	72%	p=0.047)
African Americans with 2+ cardiovascular risk factors	84%	p=0.001)
Fish consumption <1.5 servings/wk	40%	p=0.0007)
Non-Hispanic Caucasians with <1.5 servings of fish/wk	29%	p=0.04)
African Americans with <1.5 servings of fish/wk	77%	p=0.003)
African Americans with ≥1.5 servings of fish/wk	79%	p=0.01)
Age <66.7 years (median age)	40%	p=0.005)
Males	28%	p=0.02)
Non-current Smokers	21%	p=0.04)
Current Smokers	62%	p=0.02)
Medication-treated diabetes	60%	p=0.0003)
Medication-treated hypertension	42%	p=0.0002)
Taking cholesterol medication	35%	p=0.02)
Without parental history of heart attack	29%	p=0.008)
Not assigned to vitamin D	29%	p=0.02)
With 2+ cardiovascular risk factors	43%	p=0.001)
With baseline aspirin use	36%	p=0.007)
With baseline statin use	32%	p=0.04)
All-Cause Mortality
African Americans with <1.5 servings of fish/wk	36%	p=0.03)
Omega-3 vs. Placebo Post-Hoc Outcomes
Death from Heart Attack	50%	p=0.04)
Percutaneous coronary intervention (PCI; stent)	22%	p=0.02)
Coronary heart disease (heart attack, PCI, CVD death)	17%	p=0.02)

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8+ VitaminDWiki pages concern the VITAL trial

This list is automatically updated

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See also VitaminDWiki

• Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024
• Omega-3 added during pregnancy helps in many ways – Cochrane Review of RCTs Nov 2018
• Bioavailability etc. of Omega-3 – Nov 2018
• Omega-3 and Human Health: chapter in a book – Oct 2018
• Omega-3 index - good level needed 2.4 grams of regular Omega-3 - Grassroots Nov 2018 extensive information

Vitamin D and Omega-3 category starts with

408 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (44 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

Omega-3 and Meta-analysis (items in both categories)

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Review of the study by the Washington Post - April 2019

Don’t throw away your vitamin D supplements yet
"The VITAL study was poorly designed and the results have not been adequately explained in the abstract and in the press coverage. The vitamin D status of many participants was above average and the dose (2000 IU/d vitamin D3) was too low to find beneficial results for cancer incidence for the entire group. However, for those with BMI <25 kg/m2, there was a 24% reduction in all-cancer incidence. For blacks, who have lower vitamin D status than whites, there was a 23% reduction in all-cancer incidence. When the first 1-2 years of the study are omitted, there was a 21 and 25% reduction in all-cancer mortality rate. Thus, this study adds to the literature that UVB exposure and vitamin D reduce the risk of cancer incidence and mortality. Had the authors designed and analyzed the results based on achieved vitamin D status, the results would have been much stronger. One wonders whether the reporting of the results has buried the positive findings in order to benefit our disease-treatment system rather than to reduce the burden of unnecessary disease."