Vitamin D deficiency in patients with intellectual disabilities: prevalence, risk factors and management strategies
British Journal of Psychiatry online ahead of print September 25, 2014, doi: 10.1192/bjp.bp.113.143511
Valeria Frighi valeria.frighi at psych.ox.ac.uk, Alireza Morovat, Matthew T. Stephenson, Sarah J. White, Christina V. Hammond and Guy M. Goodwin
Valeria Frighi, MD, Department of Psychiatry, University of Oxford and Oxfordshire Learning Disability NHS Trust (now Southern Health NHS Foundation Trust), Oxford; Alireza Morovat, PhD, FRCPath, Department of Clinical Biochemistry, Oxford University Hospitals NHS Trust, Oxford; Matthew T. Stephenson, FRCPsych, MSysPsych, Oxfordshire Learning Disability NHS Trust (now Southern Health NHS Foundation Trust), Oxford; Sarah J. White, RGN, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford; Christina V. Hammond, BSc, Guy M. Goodwin, Dphil, FRCPsych, FMedSci, Department of Psychiatry, University of Oxford, Oxford, UK
Declaration of interest: V.F. and G.M.G. have received grants from the Baily Thomas Charitable Fund. G.M.G. has also received grants from Servier, and speaker honoraria or fees for advice from AstraZeneca, Cephalon/Teva, Eli Lilly, GSK, Lundbeck, Merck, Otsuka, Servier, Takeda and Sunovion.
Intellectually disabled 2X more likely to be vitamin D deficient (< 20 ng)
Even more likely if winter, dark skin, impared mobility, or obese
(all of which are known to be high risk categories)
See also VitaminDWiki
- Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014
- Prisoners in psychiatric wards have very low levels of vitamin D – Oct 2012
- Children with limited mobility are at high risk of being vitamin D deficient – June 2012
- All items in category Shut-in and Vitamin D
39 items - All items in category Cognition and Vitamin D
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Background: People with intellectual disabilities have a high risk of osteoporosis and fractures, which could partly be as a result of vitamin D deficiency.Aims: To compare the serum vitamin D (25(OH)D) levels of 155 patients with intellectual disabilities under psychiatric care and 192 controls, investigate potential risk factors for vitamin D deficiency in people with intellectual disabilities and assess available treatments.
Method: Cross-sectional observational study followed by treatment evaluation.
Results: Almost twice as many patients with intellectual disabilities had vitamin D deficiency (25(OH)D <50 nmol/l) compared with controls (77.3% v. 39.6%, P<0.0001).
In the intellectual disabilities group,- winter season (P<0.0001),
- dark skin pigmentation (P<0.0001),
- impaired mobility (P = 0.002) and
- obesity (P = 0.001)
were independently associated with lower serum 25(OH)D. In most patients, 800 IU colecalciferol daily normalised 25(OH)D levels.
Conclusions: Vitamin D deficiency is highly prevalent in people with intellectual disabilities,
partly because of insufficient exposure to sunlight.
Screening and treatment strategies, aiming to reduce these patients’ high fracture risk, should be introduced.
Similar strategies may be required in other psychiatric populations at risk for fractures and with a tendency to spend excessive time indoors.Publisher wants $33 for the PDF
Intellectually disabled 2X more likely to have low vitamin D (shut-in) – Sept 2014Printer Friendly Follow this page for updates5230 visitors, last modified 01 Dec, 2014, This page is in the following categories (# of items in each category) - All items in category Cognition and Vitamin D