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Highlights of Vision in VitaminDWiki

Vision problems having many studies on VitaminDWiki

112 items in Vision category


Ocular Diseases and Vitamin D genes - June 2022

Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
Nutrients 2022, 14(11), 2353; https://doi.org/10.3390/nu14112353
by Miłosz Caban andUrszula Lewandowska *ORCID Poland

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Table of Contents
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The global prevalence of eye diseases continues to grow, bringing with it a reduction in the activity levels and quality of life of patients, and partial or complete blindness if left untreated. As such, there is considerable interest in identifying more effective therapeutic options and preventive agents. One such agent is vitamin D, known to have a range of anti-cancer, anti-angiogenic, anti-inflammatory and anti-oxidative properties, and whose deficiency is linked to the pathogenesis of a range of cardiovascular, cancer, and inflammatory diseases. This review presents the current stage of knowledge concerning the link between vitamin D and its receptor and the occurrence of eye disease, as well as the influence of analogues of calcitriol, an active metabolite of vitamin D. Generally, patients affected by various ocular disorders have vitamin D deficiency. In addition, previous findings suggest that vitamin D modulates the course of eye diseases and may serve as a marker, and that its supplementation could mitigate some disorders. However, as these studies have some limitations, we recommend further randomized trials to clarify the link between vitamin D and its activity with eye disease.
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Vision Meta-analyses


112 vision articles in VitaminDWiki


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Consumer Labs summary on Vision Supplements - April 2019 (no mention of Vitamin D)
Lutein and zeaxanthin are believed to protect the macula of the eye (in the retina) from damage (see What It Does).
Many people consume relatively small amounts of lutein and zeaxanthin in their diets or have low levels of lutein in their blood; for them, taking a lutein supplement can slow the progression of age- related macular degeneration — although it won't improve the condition (see Getting lutein and zeaxanthin from food).
A dose of 10 mg of lutein appears to be better than a lower dose (6 mg). Higher dose products (e.g., 20 mg to 40 mg) are common, although it is not known if a higher dose is better. Nevertheless, 20 mg has been shown to be safe in a 6-month study.
It's not clear whether the "free" or "ester" form, or a natural or synthetic source, is better and it is not clear if there is added benefit with zeaxanthin.
Lutein and zeaxanthin at a reasonable dose (10 to 20 mg) can be obtained for as little about 15 cents per day (see What CL Found).
Other ingredients, particularly zinc, may be beneficial in slowing the progression of age-related macular degeneration. Vision formulas with these ingredients as well as lutein and zeaxanthin are available, although significantly more expensive than getting lutein/zeaxanthin alone. The formula with the strongest clinical evidence is Bausch + Lomb PreserVision AREDS Lutein (see What CL Found — Vision Formulas). One vision formula failed testing, containing only 9% of its listed lutein. To enhance absorption, it is best to take lutein and zeaxanthin supplements with a fatty meal. However, consumption of certain foods and supplements may decrease absorption of lutein and zeaxanthin (see Concerns and Cautions).


20+ VitaminDWiki pages with (MACULAR and DEGENERATION) AMD in title

This list is automatically updated

Items found: 20
Title Modified
Macular Degeneration increases risk of hemorrhagic stroke by 6X – July 2011 11 Aug, 2024
Age-Related Macular Degeneration and Vitamin D - many studies 27 Jun, 2023
Myopia, AMD, Dry Eye, and Diabetic Retinopathy are all associated with low Vitamin D - April 2023 24 Apr, 2023
LLLT reverses Age-related Macular Degeneration for a while - multiple studies 28 Nov, 2021
Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015 18 Nov, 2019
Macular Degeneration (AMD) antioxidants treated by Vitamin D in the lab – Aug 2019 24 Aug, 2019
Age-Related Macular Degeneration - Diet, bionome, Vitamin D, CBD, Avastin, etc 19 Mar, 2019
Macular Degeneration Twin Study – Vitamin D reduced, smoking increased (by 13X in later study) 15 Mar, 2019
Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017 15 Mar, 2019
Late stage AMD 2.2 more likely if low vitamin D – meta-analysis April 2016 08 Apr, 2016
Macular Degeneration decreased with UV and perhaps Vitamin D genetics– Oct 2011 04 Apr, 2016
2 Genes make AMD 6X more likely if low vitamin D - Aug 2015 04 Apr, 2016
Macular degeneration 4X more likely if low vitamin D and a particular gene – May 2013 04 Apr, 2016
Wet AMD 3X less likely if high level of vitamin D – June 2014 04 Apr, 2016
Male late stage Age-Related Macular Degeneration is strongly associated with low vitamin D – July 2014 04 Apr, 2016
UV and macular degeneration 28 Aug, 2015
Off Topic: More than 800 mg of Calcium increases risk of Macular Degeneration in seniors by 2.6X – JAMA April 2015 17 Apr, 2015
Macular Degeneration with subretinal fibrosis strongly associated with low vitamin D – July 2013 03 Aug, 2013
Off topic: Baby-sized aspirin doubles chance of getting wet macular degeneration 08 Apr, 2013
Vitamin D may help prevent macular degeneration in women younger than 75 – April 2011 06 Jul, 2011
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22030 vision genes ToC.webp admin 26 Nov, 2024 17.57 Kb 16
22029 Eye genes.webp admin 26 Nov, 2024 21.24 Kb 27
22028 Ocular Diseases and vitamin D genes_CompressPdf.pdf admin 26 Nov, 2024 322.87 Kb 10