- Overview of Poor Response
- Detailed Reasons for poor response
- Reasons for not getting benefits - even if blood tests are OK
- See also VitaminDWiki
- Big differences in UVB responses: 20 to 36 ng after 6 weeks
- Alternate sources of vitamin D
- 40-150 ng of Vitamin D needed to treat health problems
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Overview of Poor Response
~ 50% of all people have a low response to vitamin D3
~ 10% of all people have a ZERO response to a LOW dose
There are 40+ reasons for poor blood response
Here are some of the common reasonsObese Elderly Poor gut 2X more needed
or gut-friendlyHealth problem reduces levels examples
Autism, Anemia, Diabetes Some Cancers2X more needed Fail to take with the largest meal 1.3X more needed Low Magnesium, smoking 1.3X more needed Detailed Reasons for poor response
Occurrence Reason for low response Typical %
extra D
neededComments Common Excess BMI/weight 150% Obese need 2X to 3X more Common Vitamin D was not
taken with/after large meal40% Take during/after largest meal - perhaps largest = most likely to contain fat
evening meal or largest meal Note: avoid late in the eveningCommon Magnesium - low
(Gut needs Mg to absorb Vit. D)30% Many reasons - which include low stomach acid and antacids Common Smoking 30% Smoking reduces vitamin D - many studies -9 ng reduction Common mono-unsat fat ratio -low 20% Need higher ratio of mono to poly fat ratio Common Cola - soft drinks 20% Cola removes Calcium, Vit D consumed in restoring Calcium Common Boron - 15-39% Boron increases vitamin D in the blood claims 6 mg ==> 24%
-Boron is also known to build bone - perhaps by increasing vitamin DCommon Oil-based Vitamin D 20% Oil-based Vitamin D helped the least
Some olive oils decrease absorption by 25 %
Bio-Tech uses a water-soluble form of Vitamin DCommon Vitamin K2 -low 10% Overview Vitamin K and Vitamin D
perhaps 100 microgram/ 1000 IU of vitamin DCommon Cholesterol - reduced in diet N.A. Cholesterol is needed to make Vitamin D from the sun
Low Cholesterol DOES NOT appear to affect vitamin D supplementation- - - - - Sometimes Extremely Vit D deficient 200% Low dose can result in ZERO increase if very deficient
When body is very deficient all vit. D is immediately consumed
Note: sometimes extreme deficiency is due to genes.Sometimes Health - low 200% Unhealthy body consumes a lot of vitamin D - see extremely deficient
(Examples: MS, HIV, some cancers, Diabetes, Depression. .Sometimes Anemia 40% Liver is needed to process vitamin D
Sometimes need to add Iron as well as vitamin DSometimes Fatty Liver 40% Half of seniors have fatty liver, vitamin C reduces inflammation,
Calcidiol or Calcitriol might be taken instead of VitaminSometimes Drugs which consume
or block Vit D50% Taking drugs such as Statins, Antiseizure, Prednisone, AIDS drugs,
Orlistat, Questran, Dilantin, Phenobarbital, Rifampin, Methamphetamine..Sometimes Genes 50% Genes need to be functioning properly to process vitamin D
Twin studies Genetics VDBP CYP2R1 also kidney
Note: sometimes cells do not get Vitamin D even though tests are OK
see below on this pageSometimes Taking D2 vs D3 30% Sometimes D2 will actually DECREASE the level of D3
Note: D2 has a short half-life and should be taken dailySometimes Too much UVA vs UVB 20% UVA appears to actually DECREASE vitamin D levels
Avoid getting a lot of sun thru windows or very early/late in the daySometimes Winter birth 11% Winter birth, 11 % more likely to be vitamin D deficient as an adult Sometimes Oral contraceptives
INCREASE response-20% Oral Contraceptives INCREASES vitamin D levels
Perhaps due to less blood loss/anemiaSometimes Test results inaccurate +20% -20% Overview Graph of tests from 1000 labs
Vitamin D differences of 5 ng are meaningless - Aug 2015Sometimes Gut - poor 100% Bio-Mulsion form of vitamin D was designed for poor guts
Topical Vitamin D bypasses the gutSometimes Probiotic + - +20% -30% 1/3: 30% increased D bioavailability; 1/3: 20% decreases Sometimes DDT, pesticides 20% Pesticides - 2016 Sometimes Plastics, sewage based fertilizer 10% BPA PFAS PCB Sometimes Vitamin A - excessive 30% Attenuates responses for > 10,000 IU vit D: from cod liver oil or Accutane
Many children in developing countries get excess Vit A doses every 6 monthsSometimes Roundup/glyphosate ? % Gut bacteria and liver Sometimes Stress ? % Cortisol consumes Cholesterol needed to make Vitamin D Sometimes Autism 100% Autistics have half of the response to Vitamin D – RCT Oct 2018 - - - - - Rare Gallbladder removed
600,000/year in US??% Gallbladder essential to absorb vitamins dissolved in fats
Consider other forms of Vitamin D: Biomulsion, water dispersible
Also lipase to improve fat digestionRare Bariatric Surgery
which bypasses the small intestine> 200%? When to take Vitamin D
will need to get alternate source of Vitamin DRare Pancreatic Insufficiency 10-20%
of populationFat soluble vitamins (A, D, E, K) are not absorbed as well
Note: Use water-dispersible forms insteadRare Liver problems 50% Use other forms of vitamin D instead Rare Burned skin 70% Burn - uncertain response to supplementation - - - - - Sun/UV Skin - Dark 250% vitamin D produced varies with darkness of skin: White = 0%, Black = 250% Sun/UV Skin - Elderly 100% varies with age: teenager = 0%, 60 years = 100%
this due to thin skin or low cholesterol in skinSun/UV Skin - Sunburned 30% varies with % of skin which is burned
Burns and bone loss 75% less- - - - - Reduction in Vitamin D actually getting to cells - downstream from Vitamin D Testing Test invisible Genes Genes, problems which often run in families
Vitamin D Receptor 499 items as of Jan 2024
Vitamin D Binding Protein 178 items as of Nov 2024
CYP27B1 174 items as of Jan 2024Test invisible Cells Low Magnesium Test invisible Cells Low Omega-3 Test invisible Kidney Poor Kidney Note:
- Any study will rarely consider even 4 of the above factors
- Factors are sometimes additive: example, 50% + 50% = 100% = 2X as much Vitamin D is needed
Reasons for not getting benefits - even if blood tests are OK
click on image for details See also Kidney Low Magnesium, Low Omega, Vitamin D Receptor Vitamin D Binding Protein.
See also VitaminDWiki
- Response to Vitamin D - many studies
- Dietary fat increased Vitamin D response by 32% – RCT Feb 2015
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- On-line Vitamin D response simulation – July 2021
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
- Vitamin D injection helped migrants a bit, but some had poor or even negative responses – Dec 2017
- Many reasons why vitamin D deficiency has become epidemic in past 30-40 years
- 13 reasons why many seniors need more vitamin D (both dose and level) - July 2023
- Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014
- All items in category Predict Vitamin D
82 items - 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT Feb 2015
- Resveratol helps vitamin D bind to cells
- Big differences in response to same dose
Wide range in the responses after 1 year (black dots)
Example: 2400 IU dose: 75-140 nmol response (30-56 ng)
Example: 400 IU dose: 50-110 nmol response (20-44 ng)
Big differences in UVB responses: 20 to 36 ng after 6 weeks
Alternate sources of vitamin D
40-150 ng of Vitamin D needed to treat health problems
Vitamin D Treats 150 ng Multiple Sclerosis * 80 ng Cluster Headache *
Reduced office visits by 4X *70 ng Sleep * 60 ng Breast Cancer death reduced 60%
Preeclampsia RCT50 ng COVID-19
T1 Diabetes
Fertility
Psoriasis
Infections Review
Infection after surgery40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?30 ng Rickets * Evolution of experiments with patients, often also need co-factors
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Short URL = http://is.gd/lowresponseReasons for low response to vitamin D54514 visitors, last modified 21 Dec, 2024, This page is in the following categories (# of items in each category)
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