Table of contents
- Free Vitamin D 3 Index and Vitamin D-binding protein in multiple sclerosis - a presymptomatic case-control study - May 2022
- Another MS and binding study - June 2023
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7 studies in both categories Multiple Sclerosis and DBP - VitaminDWiki -
15 studies in both categories Multiple Sclerosis and Vitamin D Receptor - VitaminDWiki -
22 studies in both categories Multiple Sclerosis and Genetics - VitaminDWiki - Vitamin D Binding Protein health problems
- A simple way to fight MS resulting from poor genes is high-dose Vitamin D
Free Vitamin D 3 Index and Vitamin D-binding protein in multiple sclerosis - a presymptomatic case-control study - May 2022
Eur J Neurol. 2022 May 18. doi: 10.1111/ene.15407
Viktor Grut 1, Martin Biström 1, Jonatan Salzer 1, Pernilla Stridh 2 3, Anna Lindam 4, Lucia Alonso-Magdalena 5, Oluf Andersen 6, Daniel Jons 6, Martin Gunnarsson 7, Magnus Vrethem 8, Johan Hultdin # 9, Peter Sundström # 1Background: High levels of 25-hydroxyvitamin D3 (25OHD3 ) is associated with a lower risk for multiple sclerosis (MS). The bioavailability of 25(OH)D3 is regulated by its main plasma carrier, vitamin D-binding protein (DBP). Free 25(OH)D3 can be estimated by also measuring DBP concentration. In addition, DBP has immunomodulatory functions that may independently affect MS pathogenesis. No previous studies have assessed free 25(OH)D3 or DBP in presymptomatically collected samples.
Objective: To assess free 25(OH)D3 and DBP as risk factors for MS.
Methods: A nested case-control study was performed with presymptomatic serum samples identified through cross-linkage of MS registries and Swedish biobanks. Concentration of 25(OH)D3 was measured with liquid chromatography and DBP levels with sandwich immunoassay. Free 25(OH)D3 was approximated as Free Vitamin D3 Index: (25OHD3 /DBP)×103 . MS risk was analysed by conditional logistic regression, calculating odds ratios (ORs) with 95% confidence intervals (CIs).
Results: Serum samples from 660 pairs of matched cases and controls were included. Below 20 years of age, high levels of Free Vitamin D3 Index were associated with a lower risk of MS (highest vs lowest quintile: OR=0.37, 95% CI 0.15-0.91, p for trend across quintiles 0.04). At age 30-39, high levels of DBP were associated with a lower MS risk (highest vs lowest quintile: OR=0.36, 95% CI 0.15-0.85, p for trend 0.02).
Conclusions: These findings support the hypothesis that high levels of free 25(OH)D3 at a young age reduces the risk of MS later in life. They also implicate a role for DBP in MS aetiology.
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--Another MS and binding study - June 2023
Association of Blood Levels of Vitamin D and Its Binding Protein with Clinical Phenotypes of Multiple Sclerosis
Biomedicines . 2023 Jun 24;11(7):1808. doi: 10.3390/biomedicines11071808.
Suhail Al-Shammri 1 2, Arpita Chattopadhyay 1, Magdy Girgis Hanah 2, Suhail Doi 3, Abayomi Akanji 4Background: Low vitamin D levels may synergize with changing levels of the vitamin D binding protein (DBP) to precipitate in the development and clinical progression of multiple sclerosis (MS). In this study, this hypothesis was explored in groups of Kuwaiti healthy controls and patients with different clinical phenotypes of MS.
Methods: Fasting serum concentrations of 25-hydroxyvitamin D 25(OH)D and DBP were measured in 146 healthy controls and 195 patients with MS. The latter were classified according to the duration, type, and onset of the disease and the mode of treatment. Factors such as relapse/remitting, and the use of nutritional supplements were also considered.
Results: The DBP levels were significantly lower in the patients than in the controls. This was more evident in newly diagnosed drug-naïve patients than in those patients with more established MS. MS status and severity were negatively impacted by concurrently low levels of 25(OH)D and DBP. This was most clearly expressed in drug-naïve patients and in those with a disease in relapse. It was also established that the 25(OH)D level had a significant positive correlation with the duration of the disease.
Conclusion: Lower levels of 25(OH)D and DBP appear to have a synergistic effect on MS status. This was most clearly demonstrated in patients who were newly diagnosed (drug-naïve) and in those patients who were in relapse.
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7 studies in both categories Multiple Sclerosis and DBP This list is automatically updated
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015
- Late-stage MS associated with protein in spinal cord which blocks vitamin D – Jan 2013
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15 studies in both categories Multiple Sclerosis and Vitamin D Receptor This list is automatically updated
- VDR activators and other synergistic nutrients for the treatment of Multiple Sclerosis - Feb 2025
- Multiple Sclerosis and Vitamin D Receptor Activators
- Multiple Sclerosis: is strongly related to poor Vitamin D receptors – umbrella review Oct 2024
- Poor Vitamin D Receptor increases the risk of Multiple Sclerosis in people of European descent – Feb 2024
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Multiple Sclerosis and Vitamin D Receptor super enhancers – March 2019
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017
- Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
- Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
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22 studies in both categories Multiple Sclerosis and Genetics This list is automatically updated
- People with Multiple Sclerosis have blunted responses to Vitamin D supplementation - Jan 2024
- Get Multiple Sclerosis while younger if have a poor CYP24A1 vitamin D gene – May 2023
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- CYP2R1 gene problem increases Multiple Sclerosis risk by 1.4X – Dec 2018
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Autoimmune risk gene ZMIZ1 is associated with both MS and Vitamin D – Jan 2017
- Multiple Sclerosis relapse in children is twice as likely having a Vitamin D Gene score of 6 – Oct 2016
- Multiple Sclerosis and obesity share some gene problems (as well as low vitamin D) – June 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is connected to Vitamin D by gene to gene interactions – Aug 2014
- Multiple Sclerosis, gene expression, and vitamin D: Venn diagrams – Aug 2014
- Epigenetics of Multiple Sclerosis – March 2014
- Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
- 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
- Transgeneration vitamin D deficiency related to MS was found in mice – Aug 2012
- Epigenetics, vitamin D, and Multiple Sclerosis
- Learning about MS and vitamin D in offspring from mice – Sept 2011
- Vitamin D targets 4 MS genes – May 2011
- Unable to find a gene linking vitamin D and MS – March 2011
- MS and vitamin D may be related by HLA gene – March 2010
- MS due to low level of vitamin D may be due to a specific gene – July 2010
VitaminDWiki - Vitamin D Binding Protein health problems
Increased
RiskHealth Problem 11 X Preeclampsia 6.5X T1D in SA Blacks 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2.8 X MS 2.5 X Severe Autism 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility
A simple way to fight MS resulting from poor genes is high-dose Vitamin D
VitaminDWiki pages with HIGH-DOSE in title (62 as of May 2022)
This list is automatically updatedItems found: 82Title Modified 4 clinical trials not find change in disease risk markers with high dose vitamin D – March 2013 13 Apr, 2013 Is High Dose Vitamin D Harmful – Dec 2012 20 Dec, 2012 Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022Printer Friendly Follow this page for updates1484 visitors, last modified 30 Jul, 2023, This page is in the following categories (# of items in each category)Attached files
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